New insights into redox homeostasis as a therapeutic target in B-cell malignancies
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Purpose of review: The goal of this review is to summarize recent advances in our understanding of the regulation of redox homeostasis and the subtype-specific role of antioxidant enzymes in B-cell-derived malignancies. Furthermore, it presents selected prooxidative therapeutic strategies against B-cell neoplasms. Recent findings: Recent reports have shown that the disturbed redox homeostasis in B-cell malignancies is regulated by cancer-specific signaling pathways and therefore varies between the individual subtypes. For instance, in a subtype of diffuse large B-cell lymphoma with increased oxidative phosphorylation, elevated reactive oxygen species are accompanied by higher levels of thioredoxin and glutathione and inhibition of either of these systems is selectively toxic to this subtype. In addition, growing number of small molecule inhibitors targeting antioxidant enzymes, such as auranofin, SK053, adenanthin, or decreasing glutathione level, such as imexon, buthionine sulfoximine, and L-cysteinase, trigger specific cytotoxic effects against B-cell malignancies. Lastly, attention is drawn to recent reports of effective treatment modalities involving prooxidative agents and interfering with redox homeostasis provided by stromal cells. Summary: Recent findings reveal important differences in redox homeostasis within the distinct subsets of B-cell-derived malignancies that can be therapeutically exploited to improve existing treatment and to overcome drug resistance.
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Many cancer cells are auxotrophic for cysteine, and lowering whole-body cysteine levels with bacterial cysteineases is a potential cancer treatment being evaluated in clinical trials.
“Many cancer cells are auxotrophic for this amino acid, and lowering whole body cysteine levels with bacterial cysteineases is a potential cancer treatment being evaluated in clinical trials (Graczyk-Jarzynka et al., 2017).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Graczyk-Jarzynka et al., 2017
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- Authors
- Graczyk-Jarzynka, A., Zagozdzon, R., Muchowicz, A., Siernicka, M., Juszczynski, P., & Firczuk, M.
- Affiliations
- Department of Immunology, Center for Biostructure Research, Medical University of Warsaw
- Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw
- Medical University of Warsaw (PL)
- Institute of Hematology and Transfusion Medicine, Warsaw, Poland
- ORCID
- Muchowicz, Angelika
- Venue
- Current Opinion in Hematology
- Published
- 2017-07
- Volume
- 24
- Issue
- 4
- Pages
- 393-401
- ISSN
- 1065-6251 (ISSN-L)
- 1531-7048
- PMC
- PMC5470855
- OpenAlex
- W2607214068
- Cited by
- 29
- References
- 67
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Hematology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- redox homeostasis, B-cell malignancies, diffuse large B-cell lymphoma, oxidative phosphorylation, reactive oxygen species, thioredoxin, glutathione, antioxidant enzymes, auranofin, buthionine sulfoximine, stromal cells, drug resistance
- MeSH terms
- Clinical Studies as Topic, Animals, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Antioxidants, Cell Communication, Drug Evaluation, Preclinical, Drug Synergism, Homeostasis, Humans, Oxidation-Reduction, Signal Transduction, Leukemia, B-Cell, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Lymphoma, B-Cell, Reactive Oxygen Species, Oxidative Stress, Metabolic Networks and Pathways
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