Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities

Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus

Shi, Y., & Massagué, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00432-x · Cited by 5,860 · see citing works

Lactoferrin: molecular structure and biological function

Lönnerdal, B., & Iyer, S. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.000521 · Cited by 781 · see citing works

Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies

Kalantzi, L., Goumas, K., Kalioras, V., Abrahamsson, B., Dressman, J., & Reppas, C. I. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8476-1 · Cited by 659 · see citing works

Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin

Ellison, R. T., Giehl, T. J., & LaForce, F. M. (1988) · Infection and Immunity · doi:10.1128/iai.56.11.2774-2781.1988 · Cited by 540 · see citing works

Lactoferrin: Multifunctional roles of lactoferrin: a critical overview

Ward, P. P., Paz, E., & Conneely, O. M. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5369-8 · Cited by 443 · see citing works

Three-dimensional structure of diferric bovine lactoferrin at 2.8 Å resolution

Moore, S. A., Anderson, B. F., Groom, C. R., Haridas, M., & Baker, E. N. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.1386 · Cited by 417 · see citing works

The physiology of lactoferrin

Brock, J. H. (2002) · Biochemistry and Cell Biology · doi:10.1139/o01-212 · Cited by 401 · see citing works

Human Intelectin Is a Novel Soluble Lectin That Recognizes Galactofuranose in Carbohydrate Chains of Bacterial Cell Wall

Tsuji, S., Uehori, J., Matsumoto, M., Suzuki, Y., Matsuhisa, A., Toyoshima, K., & Seya, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103162200 · Cited by 360 · see citing works

Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA

He, J., & Furmanski, P. (1995) · Nature · doi:10.1038/373721a0 · Cited by 356 · see citing works

Molecular Cloning and Functional Expression of a Human Intestinal Lactoferrin Receptor

Suzuki, Y. A., Shin, K., & Lönnerdal, B. L. (2001) · Biochemistry · doi:10.1021/bi0155899 · Cited by 336 · see citing works

Correlative study of hydrochloric acid, pepsin, and intrinsic factor secretion in newborns and infants

Agunod, M., Yamaguchi, N., López, R., Luhby, A. L., & Glass, G. B. J. (1969) · Digestive Diseases and Sciences · doi:10.1007/bf02239360 · Cited by 289 · see citing works

Lactoferrin and iron: Structural and dynamic aspects of binding and release

Baker, H. M., & Baker, E. N. (2004) · Biometals · doi:10.1023/b:biom.0000027694.40260.70 · Cited by 265 · see citing works

Lactoferrin-lipopolysaccharide interaction: involvement of the 28-34 loop region of human lactoferrin in the high-affinity binding to Escherichia coli 055B5 lipopolysaccharide

Elass, E., Roșeanu, A., Legrand, D., Trif, M., Salmon, V., Motaş, C., Montreuil, J., & Spik, G. (1995) · Biochemical Journal · doi:10.1042/bj3120839 · Cited by 250 · see citing works

Persistence of Human Milk Proteins in the Breast‐Fed Infant

Davidson, L. A., & Lönnerdal, B. L. (1987) · Acta Paediatrica · doi:10.1111/j.1651-2227.1987.tb10557.x · Cited by 238 · see citing works

Lactoferrin Induces Concentration-Dependent Functional Modulation of Intestinal Proliferation and Differentiation

Buccigrossi, V., Marco, G. D., Bruzzese, E., Ombrato, L., Bracale, I., Polito, G., & Guarino, A. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180332c8d · Cited by 185 · see citing works

Isolation and function of a receptor for human lactoferrin in human fetal intestinal brush-border membranes

Kawakami, H., & Lönnerdal, B. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.261.5.g841 · Cited by 181 · see citing works

Apo‐ and holo‐lactoferrin are both internalized by lactoferrin receptor via clathrin‐mediated endocytosis but differentially affect ERK‐signaling and cell proliferation in caco‐2 cells

Jiang, R., López, V., Kelleher, S. L., & Lönnerdal, B. L. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22650 · Cited by 162 · see citing works

The effect of trypsin and chymotrypsin on the in vitro antimicrobial and iron-binding properties of lactoferrin in human milk and bovine colostrumUnusual resistance of human apolactoferrin to proteolytic digestion

BRINES, R., & BROCK, J. (1983) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(83)90317-3 · Cited by 152 · see citing works

Regional Postprandial Differences in pH Within the Stomach and Gastroesophageal Junction

Simonian, H. P., Vo, L., Doma, S., Fisher, R. S., & Parkman, H. P. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-3048-0 · Cited by 151 · see citing works

Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology

Drozdowski, L. A. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i7.862 · Cited by 148 · see citing works

Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis

van Berkel, P. H. C., Geerts, M., van Veen, H. A., Kooiman, P. M., Pieper, F. R., de Boer, H. A., & Nuijens, J. H. (1995) · Biochemical Journal · doi:10.1042/bj3120107 · Cited by 143 · see citing works

X-ray solution scattering reveals conformational changes upon iron uptake in lactoferrin, serum and ovo-transferrins

Grossmann, J. G., Neu, M., Pantos, E., Schwab, F. J., Evans, R. W., Townes-Andrews, E., Lindley, P. F., Appel, H., Thies, W.-G., & Hasnain, S. S. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90402-6 · Cited by 139 · see citing works

CHARACTERIZATION AND PROPERTIES OF THE HUMAN AND BOVINE LACTOTRANSFERRINS EXTRACTED FROM THE FAECES OF NEWBORN INFANTS

Spik, G., Brunet, B., Mazurier, C., Fontaine, G., & Montreuil, J. (1982) · Acta Paediatrica · doi:10.1111/j.1651-2227.1982.tb09560.x · Cited by 117 · see citing works

Cellular internalization of lactoferrin in intestinal epithelial cells

Ashida, K., Sasaki, H., Suzuki, Y. A., & Lönnerdal, B. (2004) · BioMetals · doi:10.1023/b:biom.0000027710.13543.3f · Cited by 117 · see citing works

Oral Administration of Lactoferrin Increases NK Cell Activity in Mice via Increased Production of IL-18 and Type I IFN in the Small Intestine

Kuhara, T., Yamauchi, K., Tamura, Y., & Okamura, H. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.489 · Cited by 114 · see citing works

Ontogeny, growth and development of the small intestine: Understanding pediatric gastroenterology.

Drozdowski, L. A., Clandinin, T. M., & Thomson, A. B. R. (2010) · PubMed Central · doi:10.3748/wjg.v16.i7.787 · Cited by 113 · see citing works

Expression, Characterization, and Biologic Activity of Recombinant Human Lactoferrin in Rice

Suzuki, Y. A., Kelleher, S. L., Yalda, D., Wu, L., Huang, J., Huang, N., & Lönnerdal, B. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200302000-00007 · Cited by 109 · see citing works

Concentrations of lactoferrin and iron in human milk at different stages of lactation.

Hirai, Y., Kawakata, N., Satoh, K., Ikeda, Y., Hisayasu, S., Orimo, H., & Yoshino, Y. (1990) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.36.531 · Cited by 99 · see citing works

Receptor-modulated iron release from transferrin: differential effects on N- and C-terminal sites

Bali, P. K., & Aisen, P. (1991) · Biochemistry · doi:10.1021/bi00105a019 · Cited by 87 · see citing works

α1-Antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability

Chowanadisai, W., & Lönnerdal, B. L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.828 · Cited by 79 · see citing works

Identification of an import signal for, and the nuclear localization of, human lactoferrin

Penco, S., Scarfı̀, S., Giovine, M., Damonte, G., Millo, E., Villaggio, B., Passalacqua, M., Pozzolini, M., Garrè, C., & Benatti, U. (2001) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20010038 · Cited by 76 · see citing works

Characterization of Recombinant Human Lactoferrin Secreted in Milk of Transgenic Mice

Nuijens, J. H., van Berkel, P. H. C., Geerts, M., Hartevelt, P. P., de Boer, H. A., van Veen, H. A., & Pieper, F. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8802 · Cited by 71 · see citing works

Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis

Iigo, M., Shimamura, M., Matsuda, E., Fujita, K.-I., Nomoto, H., Satoh, J., Kojima, S., Alexander, D. B., Moore, M. A., & Tsuda, H. (2003) · Cytokine · doi:10.1016/j.cyto.2003.09.009 · Cited by 68 · see citing works

Recombinant Human Intelectin Binds Bovine Lactoferrin and Its Peptides

Shin, K., Wakabayashi, H., Yamauchi, K., Yaeshima, T., & Iwatsuki, K. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1605 · Cited by 62 · see citing works

Iron Saturation Alters the Effect of Lactoferrin on the Proliferation and Differentiation of Human Enterocytes (Caco-2 Cells)

OGUCHI, S., Walker, A. W., & Sanderson, I. R. (2009) · Biology of the Neonate · doi:10.1159/000244182 · Cited by 57 · see citing works

Human Apo-Lactoferrin Enhances Angiogenesis Mediated by Vascular Endothelial Growth Factor A in vivo

Norrby, K. (2004) · Journal of Vascular Research · doi:10.1159/000078927 · Cited by 55 · see citing works

Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early lifeThis paper is one of a selection of papers published in this Special Issue, entitled 7th International Conference on Lactoferrin: Structure, Function, and Applications, and has undergone the Journal's usual peer review process.

López, V., Suzuki, Y. A., & Lönnerdal, B. L. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-059 · Cited by 48 · see citing works

Potential host-defense role of a human milk vitamin B-12–binding protein, haptocorrin, in the gastrointestinal tract of breastfed infants, as assessed with porcine haptocorrin in vitro

Adkins, Y. C., & Lönnerdal, B. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1234 · Cited by 47 · see citing works

Lactoferrin‐mediated transfer of iron to intracellular ferritin in human monocytes

Birgens, H., Kristensen, L. Ø., Borregaard, N., Karle, H., & Hansen, N. (1988) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1988.tb00868.x · Cited by 47 · see citing works

Lactoferrin Down-modulates the Activity of the Granulocyte Macrophage Colony-stimulating Factor Promoter in Interleukin-1β-stimulated Cells

Penco, S., Pastorino, S., Bianchi‐Scarrà, G., & Garrè, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12263 · Cited by 46 · see citing works

Fecal Alpha1‐Antitrypsin in Breast‐Fed Infants Is Derived from Human Milk and Is not Indicative of Enteric Protein Loss

Davidson, L. A., & Lönnerdal, B. L. (1990) · Acta Paediatrica · doi:10.1111/j.1651-2227.1990.tb11429.x · Cited by 35 · see citing works

Self-radioiodination of iodogen

Ünak, T., Akgün, Z., Yıldırım, Y., Duman, Y., & Erenel, G. (2001) · Applied Radiation and Isotopes · doi:10.1016/s0969-8043(00)00337-7 · Cited by 34 · see citing works

The secretion of intestinal alkaline phosphatase (IAP) from the enterocyte.

Alpers, D. H., Mahmood, A., Engle, M. J., YAMAGISHI, F., & Deschryver-Kecskemeti, K. (1994) · PubMed · Cited by 23 · see citing works

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

Lundquist, P., & Artursson, P. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.007 · Cited by 490 · see citing works

Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells

Liao, Y., Du, X., Li, J., & Lönnerdal, B. L. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700082 · Cited by 345 · see citing works

Infant formula and infant nutrition: bioactive proteins of human milk and implications for composition of infant formulas.

Lönnerdal, B. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071993 · Cited by 263 · see citing works

Lactoferrin, a bird’s eye view

Vogel, H. J. (2012) · Biochemistry and Cell Biology · doi:10.1139/o2012-016 · Cited by 262 · see citing works

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms

Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., German, J. B., Slupsky, C. M., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210064 · Cited by 255 · see citing works

Lactoferrin from Milk: Nutraceutical and Pharmacological Properties

Giansanti, F., Panella, G., Leboffe, L., & Antonini, G. (2016) · Pharmaceuticals · doi:10.3390/ph9040061 · Cited by 234 · see citing works

Bioactive Proteins in Human Milk: Health, Nutrition, and Implications for Infant Formulas

Lönnerdal, B. L. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.070 · Cited by 228 · see citing works

Bioactive peptides derived from human milk proteins — mechanisms of action

Wada, Y., & Lönnerdal, B. L. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.10.012 · Cited by 210 · see citing works

Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in very-low-birth-weight neonates: a randomized clinical trial

Manzoni, P., Meyer, M. P., Stolfi, I., Rinaldi, M., Cattani, S., Pugni, L., Romeo, M. G., Messner, H., Decembrino, L., Laforgia, N., et al. (2014) · Early Human Development · doi:10.1016/s0378-3782(14)70020-9 · Cited by 203 · see citing works

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand

Elzoghby, A. O., Abdelmoneem, M. A., Hassanin, I. A., Elwakil, M. M. A., Elnaggar, M. A., Mokhtar, S., Fang, J., & Elkhodairy, K. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120355 · Cited by 202 · see citing works

Exosomal MicroRNAs in Milk from Mothers Delivering Preterm Infants Survive in Vitro Digestion and Are Taken Up by Human Intestinal Cells

Kahn, S., Liao, Y., Du, X., Xu, W., Li, J., & Lönnerdal, B. L. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201701050 · Cited by 180 · see citing works

Benefits of Lactoferrin, Osteopontin and Milk Fat Globule Membranes for Infants

Demmelmair, H., Prell, C., Timby, N., & Lönnerdal, B. L. (2017) · Nutrients · doi:10.3390/nu9080817 · Cited by 160 · see citing works

Lactoferrin: Balancing Ups and Downs of Inflammation Due to Microbial Infections

Drago-Serrano, M., Campos-Rodríguez, R., Carrero, J., & De la Garza, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030501 · Cited by 151 · see citing works

Lactoferrin, a Pleiotropic Protein in Health and Disease

Mayeur, S., Spahis, S., Pouliot, Y., & Levy, E. (2016) · Antioxidants & Redox Signaling · doi:10.1089/ars.2015.6458 · Cited by 145 · see citing works

Comparing early life nutritional sources and human milk feeding practices: personalized and dynamic nutrition supports infant gut microbiome development and immune system maturation

Ames, S. R., Lotoski, L. C., & Azad, M. B. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190305 · Cited by 140 · see citing works

Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment

Luo, R., Lin, M., Fu, C., Zhang, J., Chen, Q., Zhang, C., Shi, J., Pu, X., Dong, L., Xu, H., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117998 · Cited by 132 · see citing works

Lactoferrin: Antimicrobial activity and therapeutic potential

Embleton, N. D., Berrington, J. E., McGuire, W. L., Stewart, C. J., & Cummings, S. P. (2013) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2013.02.001 · Cited by 130 · see citing works

Biological Properties of Milk-Derived Extracellular Vesicles and Their Physiological Functions in Infant

Jiang, X., You, L., Zhang, Z., Cui, X., Zhong, H. P., Sun, X., Ji, C., & Chi, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693534 · Cited by 129 · see citing works

Lactoferrin: A Critical Player in Neonatal Host Defense

Telang, S. (2018) · Nutrients · doi:10.3390/nu10091228 · Cited by 127 · see citing works

Lactoferrin: an overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance

Sienkiewicz, M., Jaśkiewicz, A., Tarasiuk, A., & Fichna, J. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895063 · Cited by 125 · see citing works

Biochemical and molecular impacts of lactoferrin on small intestinal growth and development during early life1This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process.

Liao, Y., Jiang, R., & Lönnerdal, B. L. (2012) · Biochemistry and Cell Biology · doi:10.1139/o11-075 · Cited by 125 · see citing works

Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review

de Almeida, C. C., Pereira, B. F. D. M., Leandro, K. C., da Costa, M. P., Spisso, B. F., & Conte‐Júnior, C. A. (2021) · International Journal of Food Science · doi:10.1155/2021/8850080 · Cited by 113 · see citing works

Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

Gibbons, J. A., Kanwar, J. R., & Kanwar, R. K. (2015) · BMC Cancer · doi:10.1186/s12885-015-1441-4 · Cited by 109 · see citing works

Clinical Benefits of Lactoferrin for Infants and Children

Manzoni, P. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.075 · Cited by 101 · see citing works

Concentration of Lactoferrin in Human Milk and Its Variation during Lactation in Different Chinese Populations

Yang, Z., Jiang, R., Chen, Q., Wang, J., Duan, Y., Pang, X., Jiang, S., Bi, Y., Zhang, H., Lönnerdal, B. L., et al. (2018) · Nutrients · doi:10.3390/nu10091235 · Cited by 100 · see citing works

A Review on Lactoferrin and Central Nervous System Diseases

Li, Y.-Q., & Guo, C. (2021) · Cells · doi:10.3390/cells10071810 · Cited by 91 · see citing works

Randomized Controlled Trial of Lactoferrin for Prevention of Sepsis in Peruvian Neonates Less than 2500 g

Ochoa, T. J., Zegarra, J., Cam, L., Llanos, R., Pezo, A., Cruz, K., Vera, A. G. Z., Cárcamo, C., Campos, M. A. L., & Bellomo, S. (2014) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000000593 · Cited by 88 · see citing works

Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells (HT-29) by activating various signaling pathways

Jiang, R., & Lönnerdal, B. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0094 · Cited by 88 · see citing works

Characterization of the bovine milk proteome in early-lactation Holstein and Jersey breeds of dairy cows

Tacoma, R., Fields, J. G., Ebenstein, D. B., Lam, Y., & Greenwood, S. L. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.09.024 · Cited by 81 · see citing works

The In Vitro Protective Role of Bovine Lactoferrin on Intestinal Epithelial Barrier

Zhao, X., Xu, X., Liu, Y., Xi, E.-Z., An, J., Tabys, D., & Liu, N. (2019) · Molecules · doi:10.3390/molecules24010148 · Cited by 80 · see citing works

A lactoferrin-receptor, intelectin 1, affects uptake, sub-cellular localization and release of immunochemically detectable lactoferrin by intestinal epithelial Caco-2 cells

Akiyama, Y., Oshima, K., Kuhara, T., Shin, K., Abe, F., Iwatsuki, K., Nadano, D., & Matsuda, T. (2013) · The Journal of Biochemistry · doi:10.1093/jb/mvt073 · Cited by 78 · see citing works

Bioactive Proteins in Human Milk—Potential Benefits for Preterm Infants

Lönnerdal, B. L. (2016) · Clinics in Perinatology · doi:10.1016/j.clp.2016.11.013 · Cited by 78 · see citing works

Dietary Bovine Lactoferrin Increases Intestinal Cell Proliferation in Neonatal Piglets

Reznikov, E. A., Comstock, S. S., Yi, C., Contractor, N., & Donovan, S. M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.196568 · Cited by 75 · see citing works

Cow’s Milk and Immune Function in the Respiratory Tract: Potential Mechanisms

Perdijk, O., van Splunter, M. E., Savelkoul, H. F. J., Brugman, S., & van Neerven, R. J. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00143 · Cited by 71 · see citing works

The Role of Lactoferrin in Intestinal Health

Conesa, C., Bellés, A., Grasa, L., & Sánchez, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061569 · Cited by 70 · see citing works

Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk

Hård, A., Nilsson, A., Lund, A., Pupp, I. H., Smith, L. E. H., & Hellström, A. (2018) · Acta Paediatrica · doi:10.1111/apa.14702 · Cited by 68 · see citing works

Raw cow’s milk consumption and allergic diseases – The potential role of bioactive whey proteins

Abbring, S., Hols, G., Garssen, J., & van Esch, B. C. A. M. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.013 · Cited by 65 · see citing works

Bovine lactoferrin regulates cell survival, apoptosis and inflammation in intestinal epithelial cells and preterm pig intestine

Nguyen, D. N., Jiang, P., Stensballe, A., Bendixen, E., Sangild, P. T., & Chatterton, D. E. W. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.03.020 · Cited by 65 · see citing works

Effect of Lactoferrin Supplementation on Inflammation, Immune Function, and Prevention of Respiratory Tract Infections in Humans: A Systematic Review and Meta-analysis

Berthon, B. S., Williams, L. M., Williams, E. J., & Wood, L. G. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac047 · Cited by 62 · see citing works

Food Protein Based Core–Shell Nanocarriers for Oral Drug Delivery: Effect of Shell Composition on in Vitro and in Vivo Functional Performance of Zein Nanocarriers

Alqahtani, M. S., Islam, M., Podaralla, S. K., Kaushik, R. S., Reineke, J., Woyengo, T. A., & Perumal, O. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01017 · Cited by 61 · see citing works

Assessment of bioactivities of the human milk lactoferrin–osteopontin complex in vitro

Liu, L., Jiang, R., & Lönnerdal, B. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.03.016 · Cited by 57 · see citing works

Effects of bovine lactoferrin on the immature porcine intestine

Nguyen, D. N., Li, Y., Sangild, P. T., Bering, S. B., & Chatterton, D. E. W. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513002456 · Cited by 56 · see citing works

Types of acute phase reactants and their importance in vaccination (Review)

Khalil, R., & Al-Humadi, N. H. (2020) · Biomedical Reports · doi:10.3892/br.2020.1276 · Cited by 55 · see citing works

Human lactoferrin attenuates the proinflammatory response of neonatal monocyte-derived macrophages

Wisgrill, L., Wessely, I., Spittler, A., Förster‐Waldl, E., Berger, A., & Sadeghi, K. (2018) · Clinical & Experimental Immunology · doi:10.1111/cei.13108 · Cited by 53 · see citing works

Molecular Determinants of Milk Lactoferrin as a Bioactive Compound in Early Neurodevelopment and Cognition

Wang, B. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.02.073 · Cited by 52 · see citing works

The bovine Lactoferrin-Osteopontin complex increases proliferation of human intestinal epithelial cells by activating the PI3K/Akt signaling pathway

Liu, L., Jiang, R., Liu, J., & Lönnerdal, B. L. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125919 · Cited by 51 · see citing works

Effects of lactoferrin on intestinal epithelial cell growth and differentiation: an in vivo and in vitro study

Blais, A., Fan, C., Voisin, T., Aattouri, N., Dubarry, M., Blachier, F., & Tomé, D. (2014) · BioMetals · doi:10.1007/s10534-014-9779-7 · Cited by 51 · see citing works

Lactoferrin and Necrotizing Enterocolitis

Sherman, M. P. (2013) · Clinics in Perinatology · doi:10.1016/j.clp.2012.12.006 · Cited by 49 · see citing works

The role of microbiome-host interactions in the development of Alzheimer´s disease

Weber, C., Dilthey, A., & Finzer, P. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1151021 · Cited by 48 · see citing works

Evidence for human milk as a biological system and recommendations for study design—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 4

Donovan, S. M., Aghaeepour, N., Andres, A., Azad, M. B., Becker, M., Carlson, S. E., Järvinen, K. M., Lin, W., Lönnerdal, B. L., Slupsky, C. M., et al. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2022.12.021 · Cited by 46 · see citing works

Comparison of Bioactivities of Talactoferrin and Lactoferrins From Human and Bovine Milk

Jiang, R., Du, X., & Lönnerdal, B. L. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000481 · Cited by 46 · see citing works

Effect of iron saturation level of lactoferrin on osteogenic activity in vitro and in vivo

Wang, X. Y., Guo, H., Zhang, W., Wen, P., Zhang, H., Guo, Z. R., & Ren, F. (2012) · Journal of Dairy Science · doi:10.3168/jds.2012-5692 · Cited by 45 · see citing works

Lactoferrin up-regulates intestinal gene expression of brain-derived neurotrophic factors BDNF, UCHL1 and alkaline phosphatase activity to alleviate early weaning diarrhea in postnatal piglets

Yang, C., Zhu, X., Liu, N., Chen, Y., Gan, H., Troy, F. A., & Wang, B. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.03.015 · Cited by 44 · see citing works

Lactoferrin: A Nutraceutical with Activity against Colorectal Cancer

Rico, G. R., Drago-Serrano, M. E., León-Sicairos, N. M., & de la Garza, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.855852 · Cited by 44 · see citing works

Iron Absorption Is Greater from Apo-Lactoferrin and Is Similar Between Holo-Lactoferrin and Ferrous Sulfate: Stable Iron Isotope Studies in Kenyan Infants

Mikulic, N., Uyoga, M. A., Mwasi, E., Stoffel, N. U., Zeder, C., Karanja, S., & Zimmermann, M. B. (2020) · The Journal of Nutrition · doi:10.1093/jn/nxaa226 · Cited by 41 · see citing works

Biological activities of commercial bovine lactoferrin sources

Lönnerdal, B. L., Du, X., & Jiang, R. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0182 · Cited by 40 · see citing works

In vitro evaluation of bovine lactoferrin potential as an anticancer agent

Zhang, Y., Lima, C. F., & Rodrigues, L. R. (2014) · International Dairy Journal · doi:10.1016/j.idairyj.2014.08.016 · Cited by 39 · see citing works

A comparative review of intelectins

Chen, L., Li, J., & Yang, G. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12882 · Cited by 39 · see citing works

Oral delivery of peptide therapeutics in infants: Challenges and opportunities

Gleeson, J. P., Fein, K. C., & Whitehead, K. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.011 · Cited by 39 · see citing works

Identification of Unprecedented Anticancer Properties of High Molecular Weight Biomacromolecular Complex Containing Bovine Lactoferrin (HMW-bLf)

Ebrahim, F. O., Narayanan, J. S. S., Kanwar, J. R., Gurudevan, S., Krishnan, U. M., & Kanwar, R. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106568 · Cited by 39 · see citing works

Whey and Whey Products

Anand, S. K., Nath, K. S., & Marella, C. (2013) · Wiley eBooks · doi:10.1002/9781118534168.ch22 · Cited by 39 · see citing works

Comparative Analysis of the Protein Composition of Goat Milk from French Alpine, Nubian, and Creole Breeds and Holstein Friesian Cow Milk: Implications for Early Infant Nutrition

Muñoz-Salinas, F., Andrade-Montemayor, H. M., de la Torre‐Carbot, K., Duarte‐Vázquez, M. A., & Silva-Jarquin, J. C. (2022) · Animals · doi:10.3390/ani12172236 · Cited by 38 · see citing works

Evaluation of Bioactivities of the Bovine Milk Lactoferrin–Osteopontin Complex in Infant Formulas

Jiang, R., Liu, L., Du, X., & Lönnerdal, B. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b07988 · Cited by 37 · see citing works

Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G

van Splunter, M. E., van Osch, T. L. J., Brugman, S., Savelkoul, H. F. J., Joosten, L. A. B., Netea, M. G., & van Neerven, R. J. J. (2018) · Nutrients · doi:10.3390/nu10101378 · Cited by 36 · see citing works

Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Manzoni, P., Sánchez, R. G., Meyer, M. P., Stolfi, I., Pugni, L., Messner, H., Cattani, S., Betta, P., Memo, L., Decembrino, L., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.09.080 · Cited by 36 · see citing works

The role of orally ingested milk fat globule membrane on intestinal barrier functions evaluated with a suckling rat pup supplementation model and a human enterocyte model

Jiang, R., Du, X., Brink, L., & Lönnerdal, B. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109084 · Cited by 32 · see citing works

Bovine Lactoferrin Modulates Dendritic Cell Differentiation and Function

Perdijk, O., van Neerven, R. J. J., den Brink, E. V., Savelkoul, H. F. J., & Brugman, S. (2018) · Nutrients · doi:10.3390/nu10070848 · Cited by 32 · see citing works

Lactoferrin may inhibit the development of cancer via its immunostimulatory and immunomodulatory activities

Pan, S., Weng, H., Hu, G., Wang, S., Zhao, T., Yao, X., Liao, L., Zhu, X., & Ge, Y. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5265 · Cited by 31 · see citing works

Bovine Lactoferrin Enhances TLR7-Mediated Responses in Plasmacytoid Dendritic Cells in Elderly Women: Results From a Nutritional Intervention Study With Bovine Lactoferrin, GOS and Vitamin D

van Splunter, M. E., Perdijk, O., Fick-Brinkhof, H., Feitsma, A. L., Vollenbroek, E. G. M., Meijer, B., Brugman, S., Savelkoul, H. F. J., van Hoffen, E., & van Neerven, R. J. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02677 · Cited by 30 · see citing works

Oral fate and stabilization technologies of lactoferrin: a systematic review

Wei, Y., Feng, K., Li, S., Hu, T., Linhardt, R. J., Zong, M., & Wu, H. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1900774 · Cited by 30 · see citing works

Potential Protective Protein Components of Cow’s Milk against Certain Tumor Entities

Leischner, C., Egert, S., Burkard, M., & Venturelli, S. (2021) · Nutrients · doi:10.3390/nu13061974 · Cited by 29 · see citing works

A review of the safety evidence on recombinant human lactoferrin for use as a food ingredient

Vishwanath-Deutsch, R., Dallas, D. C., Besada‐Lombana, P. B., Katz, L., Conze, D. B., Kruger, C. L., Clark, A. J., Peterson, R., & Malinczak, C. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114727 · Cited by 28 · see citing works

Bovine lactoferrin digested with human gastrointestinal enzymes inhibits replication of human echovirus 5 in cell culture

Furlund, C. B., Kristoffersen, A. B., Devold, T. G., Vegarud, G. E., & Jonassen, C. M. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.006 · Cited by 28 · see citing works

Kinetic modelling of the heat stability of bovine lactoferrin in raw whole milk

Liu, H., Boggs, I., Weeks, M., Li, Q., Wu, H., Harris, P., Ma, Y., & Day, L. (2020) · Journal of Food Engineering · doi:10.1016/j.jfoodeng.2020.109977 · Cited by 28 · see citing works

Transcriptomic profiling of intestinal epithelial cells in response to human, bovine and commercial bovine lactoferrins

Jiang, R., & Lönnerdal, B. (2014) · BioMetals · doi:10.1007/s10534-014-9746-3 · Cited by 27 · see citing works

Milk Bioactive Proteins and Peptides

Korhonen, H. J. T., & Marnila, P. (2013) · Wiley eBooks · doi:10.1002/9781118534168.ch8 · Cited by 26 · see citing works

Ratio of dietary rumen degradable protein to rumen undegradable protein affects nitrogen partitioning but does not affect the bovine milk proteome produced by mid-lactation Holstein dairy cows

Tacoma, R., Fields, J. G., Ebenstein, D. B., Lam, Y., & Greenwood, S. L. (2017) · Journal of Dairy Science · doi:10.3168/jds.2017-12647 · Cited by 24 · see citing works

Milk-Derived miR-22-3p Promotes Proliferation of Human Intestinal Epithelial Cells (HIECs) by Regulating Gene Expression

Jiang, R., & Lönnerdal, B. L. (2022) · Nutrients · doi:10.3390/nu14224901 · Cited by 21 · see citing works

Cow Milk Lactoferrin Possesses Several Catalytic Activities

Soboleva, S. E., Sedykh, S. E., Alinovskaya, L. I., Buneva, V. N., & Nevinsky, G. A. (2019) · Biomolecules · doi:10.3390/biom9060208 · Cited by 21 · see citing works

Microbiota-based therapies as novel targets for autism spectrum disorder: A systematic review and meta-analysis

Hassib, L., Kanashiro, A., Pedrazzi, J. F. C., Vercesi, B. F., Higa, S., Arruda, Í., Soares, Y., de Souza, A. P., Barichello, T., Guimarães, F. S., et al. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111385 · Cited by 19 · see citing works

Protective Effect of Bovine Lactoferrin Against Cronobacter Sakazakii in Human Intestinal Caco-2/Tc7 Cells

Abad, I., Sangüesa, A., Ubieto, M., Carramiñana, J. J., Pérez, M. D., Buey, B., Mesonero, J. E., Grasa, L., & Sánchez, L. (2022) · International Dairy Journal · doi:10.1016/j.idairyj.2022.105428 · Cited by 19 · see citing works

Comparative proteomic analysis of donor human milk pasteurized by hydrostatic high-pressure

Zhang, J., Duley, J. A., Cowley, D. M., Shaw, P. N., Koorts, P. J., & Bansal, N. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134264 · Cited by 19 · see citing works

The effects of milk and colostrum on allergy and infection: Mechanisms and implications

van Neerven, R. J. J. (2014) · Animal Frontiers · doi:10.2527/af.2014-0010 · Cited by 18 · see citing works

Clinical research review: usefulness of bovine lactoferrin in child health

Miyakawa, M., Oda, H., & Tanaka, M. (2022) · BioMetals · doi:10.1007/s10534-022-00430-4 · Cited by 18 · see citing works

Iron transport mechanism of lactoferrin and its application in food processing

Fu, J., Liu, Y., Tan, D., & Liu, L. (2023) · Food Science and Technology · doi:10.1590/fst.121122 · Cited by 17 · see citing works

Development and validation of an enzyme-linked immunosorbent assay for the determination of bovine lactoferrin in various milk products

Ostertag, F., Sommer, D., Berensmeier, S., & Hinrichs, J. (2021) · International Dairy Journal · doi:10.1016/j.idairyj.2021.105246 · Cited by 15 · see citing works

Structure and function of fermentation-derived bovine lactoferrin produced from Komagataella phaffii

Skoog, E., Castagna, V. F., Omer, S., Madigan, J., Flagg, V., Burrick, K., Jiang, R., Du, X., Lönnerdal, B., & Schnitzler, A. C. (2024) · Biochemistry and Cell Biology · doi:10.1139/bcb-2024-0105 · Cited by 14 · see citing works

Evaluation of the potential food allergy risks of human lactoferrin expressed in Komagataella phaffii

Anaya, Y., Martinez, R. R., Goodman, R. E., Johnson, P. E., Vajpeyi, S., Lu, X., Peterson, R., Weyers, S. M., Breen, I. L., Newsham, K., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1380028 · Cited by 13 · see citing works

Insights into Novel Infant Milk Formula Bioactives

Skolnick, J., Chou, C., & Miklavcic, J. J. (2020) · Nutrition and Dietary Supplements · doi:10.2147/nds.s192099 · Cited by 13 · see citing works

Biomimetic engineered nanocarriers inspired by viruses for oral-drug delivery

Zhang, J., Liu, X., Lin, J., Bao, X., Peng, J., Gong, Z., Luan, X., & Chen, Y. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121979 · Cited by 13 · see citing works

Enrichment of Lactoferrin and Immunoglobulin G from Acid Whey by Cross-Flow Filtration

Ostertag, F., & Hinrichs, J. (2023) · Foods · doi:10.3390/foods12112163 · Cited by 12 · see citing works

Dose Range-Finding Toxicity Study in Rats With Recombinant Human Lactoferrin Produced in Komagataella phaffii

Peterson, R., Crawford, R. B., Blevins, L. K., Kaminski, N. E., Sass, J. S., Ferraro, B., Vishwanath-Deutsch, R., Clark, A. J., & Malinczak, C. (2024) · International Journal of Toxicology · doi:10.1177/10915818241247013 · Cited by 12 · see citing works

The impact of complexation or complex coacervation of lactoferrin and osteopontin on simulated infant gastrointestinal digestion, intestinal inflammation, and in vivo bone development

Goulding, D. A., Bonnet, N., Horcajada, M.-N., Baruchet, M., Bermont, F., Hauser, J., Macrı̀, S., Pisa, E., Nembrini, C., Vidal, K., et al. (2024) · Food & Function · doi:10.1039/d4fo02790f · Cited by 12 · see citing works

Lactoferrin and the lactoferrin–sophorolipids-assembly can be internalized by dermal fibroblasts and regulate gene expression

Jiang, R., Suzuki, Y. A., Du, X., & Lönnerdal, B. L. (2016) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0090 · Cited by 12 · see citing works

Lingual antimicrobial peptide and lactoferrin concentrations and lactoperoxidase activity in bovine colostrum are associated with subsequent somatic cell count

Isobe, N., Shibata, A., Kubota, H., & Yoshimura, Y. (2013) · Animal Science Journal · doi:10.1111/asj.12113 · Cited by 12 · see citing works

Purification of lactoferrin through a sequential filtration and magnetic separation process: A processing example for acid whey valorization

Krolitzki, E., Ostertag, F., Schwaminger, S. P., Hinrichs, J., & Berensmeier, S. (2024) · Future Foods · doi:10.1016/j.fufo.2024.100342 · Cited by 11 · see citing works

Molecular Characterization and Expression of Lactoferrin Receptor (LfR) in Different Regions of the Brain Responding to Lactoferrin Intervention

Wang, S., Zhang, N., Jiang, B., Lönnerdal, B. L., Chen, Y., & Wang, B. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04378-z · Cited by 11 · see citing works

DNase and RNase activities of fresh cow milk lactoferrin

Soboleva, S. E., Zakharova, O. D., Sedykh, S. E., Ivanisenko, N. V., Buneva, V. N., & Nevinsky, G. A. (2019) · Journal of Molecular Recognition · doi:10.1002/jmr.2777 · Cited by 11 · see citing works

Omics Analysis of Extracellular Vesicles Recovered from Infant Formula Products and Milk: Towards Personalized Infant Nutrition

Turner, N. P., Abeysinghe, P., Sadowski, P. G., & Mitchell, M. D. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300404 · Cited by 10 · see citing works

Supplementation of infant formulas with recombinant human lactoferrin and/or galactooligosaccharides increases iron bioaccessibility as measured by ferritin formed in Caco-2 cell model

Aly, E., López‐Nicolás, R., Darwish, A. A., Frontela‐Saseta, C., & Ros, G. (2016) · Food Research International · doi:10.1016/j.foodres.2016.08.030 · Cited by 10 · see citing works

Bovine Lactoferrin, Human Lactoferrin, and Bioactivity

Bhatia, J. J. S. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e318233527a · Cited by 4 · see citing works

Lactoferrin Induces Concentration-Dependent Functional Modulation of Intestinal Proliferation and Differentiation

Buccigrossi, V., Marco, G. D., Bruzzese, E., Ombrato, L., Bracale, I., Polito, G., & Guarino, A. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180332c8d · Cited by 185 · see citing works

Comparison of Bioactivities of Talactoferrin and Lactoferrins From Human and Bovine Milk

Jiang, R., Du, X., & Lönnerdal, B. L. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000481 · Cited by 46 · see citing works

Dietary Bovine Lactoferrin Increases Intestinal Cell Proliferation in Neonatal Piglets

Reznikov, E. A., Comstock, S. S., Yi, C., Contractor, N., & Donovan, S. M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.196568 · Cited by 75 · see citing works

Biological activities of commercial bovine lactoferrin sources

Lönnerdal, B. L., Du, X., & Jiang, R. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0182 · Cited by 40 · see citing works