Cited by 48Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingAlzheimer's disease research and treatments

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Early and Persistent Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

Bencsik, Anna, Muselli, Letizia, Leboidre, Mikael, Lakhdar, Latifa, Baron, Thierry·2014·Journal of Neuropathology & Experimental Neurology

DOI 10.1097/nen.0000000000000137

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Abstract

Alpha-synuclein is a key protein in Parkinson disease (PD) and dementia with Lewy bodies. It is found in Lewy bodies in the brains of PD patients and has been reported in the peripheral nervous system in postmortem tissues from PD patients and in biopsies from patients in the preclinical phase of PD. Here, we used a transgenic mouse model of human synucleinopathies expressing the A53T mutant α-synuclein (TgM83) in which a neurodegenerative process associated with α-synuclein occurs spontaneously and increases with age. In particular, α-synuclein protein phosphorylated at serine 129 (pSer129 α-synuclein) naturally and progressively increases in diseased brains. We examined the time course of pSer129 α-synuclein presence in the gut of these mice between 1.5 and 22 months of age using immunohistochemistry and paraffin-embedded tissue blots. The pSer129 α-synuclein accumulated early (before the onset of motor signs) and persistently in the enteric nervous system and was concomitantly found in the brain. These results suggest that the accumulation of phosphorylated α-synuclein in the enteric and central nervous systems may result from parallel pathologic processes when the disease is linked to a mutation of α-synuclein.

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Authors: Bencsik, A., Muselli, L., Leboidre, M., Lakhdar, L., & Baron, T.
Affiliations: Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
Corresponding author: Bencsik, Anna
ORCID: Bencsik, Anna
Baron, Thierry
Venue: Journal of Neuropathology & Experimental Neurology
Publisher: Oxford University Press (OUP)
Published: 2014-12
Volume: 73
Issue: 12
Pages: 1144-1151
ISSN: 0022-3069 (ISSN-L)
1554-6578
DOI: 10.1097/nen.0000000000000137
OpenAlex: W2091489444
Cited by: 48
References: 51
Citations by year: 2025: 2 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 1
FWCI: 1.30
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neuropathology & Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: alpha-synuclein, A53T mutant, phosphorylated alpha-synuclein, enteric nervous system, Parkinson's disease, dementia with Lewy bodies, synucleinopathies, Lewy bodies, gut-brain axis, neurodegeneration
MeSH terms: Animals, Gene Expression Regulation, Humans, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Parkinson Disease, Phosphorylation, Enteric Nervous System, Mice, alpha-Synuclein

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Early and Persistent Expression of Phosphorylated α-Synuclein in the Enteric Nervous System of A53T Mutant Human α-Synuclein Transgenic Mice

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