Gut Metagenomics-Derived Genes as Potential Biomarkers of Parkinson’s Disease
Open accessAbstract
Identification of the gut microbiome compositions associated with disease has become a research focus worldwide. Emerging evidence has revealed the presence of gut microbiota dysbiosis in Parkinson's disease. In this study, we aimed to identify the gut microbiome associated with Parkinson's disease and subsequently to screen and to validate potential diagnostic biomarkers of Parkinson's disease. This case-control study investigated gut microbial genes in faeces from 40 volunteer Chinese patients with Parkinson's disease and their healthy spouses using shotgun metagenomic sequencing. Furthermore, the identified specific gut microbial gene markers were validated with real-time PCR in an independent Chinese cohort of 78 Parkinson's disease patients, 75 control subjects, 40 patients with multiple system atrophy and 25 patients with Alzheimer's disease. We developed the first gut microbial gene catalogue associated with Parkinson's disease. Twenty-five gene markers were identified that distinguished Parkinson's disease patients from healthy control subjects, achieving an area under the receiver operating characteristic curve (AUC) of 0.896 (95% confidence interval: 83.1-96.1%). A highly accurate Parkinson's disease index, which was not influenced by disease severity or Parkinson's disease medications, was created. Testing these gene markers using quantitative PCR distinguished Parkinson's disease patients from healthy controls not only in the 40 couples (AUC = 0.922, 95% confidence interval: 86.4-98.0%), but also in an independent group of 78 patients with Parkinson's disease and 75 healthy control subjects (AUC = 0.905, 95% confidence interval: 86.0-95.1%). This classifier also performed a differential diagnosis power in discriminating these 78 patients with Parkinson's disease from a cohort of 40 patients with multiple system atrophy and 25 patients with Alzheimer's disease based on the panel of 25 biomarkers. Based on our results, the identified Parkinson's disease index based on the gene set from the gut microbiome may be a potential diagnostic biomarker of Parkinson's disease.
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GM-based biomarkers have recently been considered as promising early and prodromal diagnostic tools in various neurological diseases, such as multiple sclerosis, Alzheimer's disease and Parkinson's disease itself.
“GM-based biomarkers have recently been considered as promising early and prodromal diagnostic tools in various neurological diseases, such as multiple sclerosis, AD and PD itself [30,156,157]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [157]
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- Authors
- Qian, Y., Yang, X., Xu, S., Huang, P., Li, B., Du, J., He, Y., Su, B., Xu, L.-M., Wang, L., Huang, R., Chen, S., & Xiao, Q.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Department of Biostatistics, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P.R. China
- Department of Bioinformatics, Shanghai Biotechnology Corporation, Shanghai, 200025, P.R. China
- Corresponding author
- Chen, Shengdi
- Xiao, Qin
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-08-01
- Volume
- 143
- Issue
- 8
- Pages
- 2474-2489
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W3081307311
- Cited by
- 139
- References
- 75
- Citations by year
- 2026: 22 · 2025: 25 · 2024: 23 · 2023: 26 · 2022: 33 · 2021: 10
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key R&D Program of China (2016YFC1306000)
- National Natural Science Foundation of China (81071023, 81430022, 81771374)
- Shanghai Municipal Science and Technology Major Project (2018SHZDZX05)
- Shanghai Sailing Program (18YF1414000)
- Doctoral Innovation Fund
- Shanghai Jiao Tong University School of Medicine (BXJ201714)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Parkinson's disease, gut microbiota, diagnostic biomarkers, metagenomics, multiple system atrophy, Alzheimer's disease, differential diagnosis, fecal microbiota, dysbiosis
- MeSH terms
- Gastrointestinal Microbiome, Aged, Feces, Female, Genetic Markers, Humans, Male, Middle Aged, Parkinson Disease, Case-Control Studies, Metagenomics
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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