Enteric alpha‐synuclein expression is increased in P arkinson's disease but not A lzheimer's disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B., & Olanow, C. W. (2008) · Nature Medicine · doi:10.1038/nm1747 · Cited by 1,722 · see citing works

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

Braak, H., R�b, U., Gai, W. P., & Del Tredici, K. (2003) · Journal of Neural Transmission · doi:10.1007/s00702-002-0808-2 · Cited by 1,683 · see citing works

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

(1998) · Europe PMC (PubMed Central) · Cited by 1,594 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Parkinson's disease: a dual‐hit hypothesis

Hawkes, C. H., Del Tredici, K., & Braak, H. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00874.x · Cited by 1,021 · see citing works

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

Arizona Parkinson’s Disease Consortium, Beach, T. G., Adler, C. H., Sue, L. I., Vedders, L., Lue, L., White III, C. L., Akiyama, H., Caviness, J. N., Shill, H. A., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0664-3 · Cited by 911 · see citing works

Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease

Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839 · see citing works

Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry

Hamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754 · see citing works

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works

Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?

Compta, Y., Parkkinen, L., O’Sullivan, S. S., Vandrovcová, J., Holton, J. L., Collins, C., Lashley, T., Kallis, C., Williams, D. R., de Silva, R., et al. (2011) · Brain · doi:10.1093/brain/awr031 · Cited by 585 · see citing works

Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes

Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533 · see citing works

Alpha-synuclein in colonic submucosa in early untreated Parkinson’s disease

Shannon, K. M., Keshavarzian, A., Mutlu, E., Dodiya, H. B., Daian, D., Jaglin, J. A., & Kordower, J. H. (2012) · Movement Disorders · doi:10.1002/mds.23838 · Cited by 469 · see citing works

Is alpha-synuclein in the colon a biomarker for premotor Parkinson’s disease? Evidence from 3 cases

Shannon, K. M., Keshavarzian, A., Dodiya, H. B., Jakate, S., & Kordower, J. H. (2012) · Movement Disorders · doi:10.1002/mds.25020 · Cited by 464 · see citing works

Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

Lebouvier, T., Neunlist, M., Bruley des Varannes, S., Coron, E., Drouard, A., N'Guyen, J.-M., Chaumette, T., Tasselli, M., Paillusson, S., Flamand, M., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012728 · Cited by 427 · see citing works

α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects

Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 330 · see citing works

Are synucleinopathies prion-like disorders?

Angot, É., Steiner, J. A., Hansen, C., Li, J., & Brundin, P. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70213-1 · Cited by 283 · see citing works

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

Angot, E., Steiner, J. A., Lema Tomé, C. M., Ekström, P., Mattsson, B., Björklund, A., & Brundin, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039465 · Cited by 270 · see citing works

Is Parkinson's disease a prion disorder?

Olanow, C. W., & Prusiner, S. B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906759106 · Cited by 266 · see citing works

Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by α-synuclein immunocytochemistry

Braak, H., Sandmann-Keil, D., Gai, W., & Braak, E. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00208-6 · Cited by 242 · see citing works

Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies

Kaufmann, H., Nahm, K., Purohit, D. P., & WOLFE, D. E. (2004) · Neurology · doi:10.1212/01.wnl.0000138500.73671.dc · Cited by 239 · see citing works

Non-A.beta. Component of Alzheimer's Disease Amyloid (NAC) is Amyloidogenic

Iwai, A., Yoshimoto, M., Masliah, E., & Saitoh, T. (1995) · Biochemistry · doi:10.1021/bi00032a006 · Cited by 237 · see citing works

Interaction between Aβ Peptide and α Synuclein: Molecular Mechanisms in Overlapping Pathology of Alzheimer’s and Parkinson’s in Dementia with Lewy Body Disease

Mandal, P. K., Pettegrew, J. W., Masliah, E., Hamilton, R. L., & Mandal, R. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9140-9 · Cited by 219 · see citing works

Bowel movement frequency in late‐life and incidental Lewy bodies

Abbott, R. D., Ross, G. W., Petrovitch, H., Tanner, C. M., Davis, D. G., Masaki, K., Launer, L. J., Curb, J. D., & White, L. R. (2007) · Movement Disorders · doi:10.1002/mds.21560 · Cited by 203 · see citing works

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

Yoshimoto, M., Iwai, A., Kang, D. E., Otero, D. A., Xia, Y., & Saitoh, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9141 · Cited by 202 · see citing works

α-Synuclein pathology in Parkinson’s and Alzheimer’s disease brain: incidence and topographic distribution—a pilot study

Jellinger, K. A. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0725-y · Cited by 201 · see citing works

Autonomic dysfunction in Parkinson's disease: a comprehensive symptom survey

Siddiqui, M. F., Rast, S. A., Lynn, M., Auchus, A. P., & Pfeiffer, R. F. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00052-9 · Cited by 195 · see citing works

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

Phillips, R. J., Walter, G. C., Wilder, S. L., Baronowsky, E. A., & Powley, T. L. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.02.074 · Cited by 189 · see citing works

Do α-synuclein aggregates in autonomic plexuses predate Lewy body disorders?

Mínguez‐Castellanos, A., Chamorro, C. E., Sevilla, F. E., Ortega-Moreno, A., Rebollo, A. C., Gómez-Río, M., Concha, A., & Muñoz, D. G. (2007) · Neurology · doi:10.1212/01.wnl.0000264429.59379.d9 · Cited by 183 · see citing works

Evaluation of α-synuclein immunohistochemical methods used by invited experts

Beach, T. G., White, C. L., Hamilton, R. L., Duda, J. E., Iwatsubo, T., Dickson, D. W., Leverenz, J. B., Roncaroli, F., Buttini, M., Hladik, C. L., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0409-8 · Cited by 182 · see citing works

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.

Masliah, E., Iwai, A., Mallory, M. E., Uéda, K., & Saitoh, T. (1996) · Europe PMC (PubMed Central) · Cited by 166 · see citing works

α-synuclein phosphorylation and truncation are normal events in the adult human brain

Muntané, G., Ferrer, I., & Martínez‐Vicente, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.10.042 · Cited by 150 · see citing works

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

Gallardo, G., Schlüter, O. M., & Südhof, T. C. (2008) · Nature Neuroscience · doi:10.1038/nn2058 · Cited by 145 · see citing works

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

Bottner, M. B., Zorenkov, D., Hellwig, I., Barrenschee, M., Harde, J., Fricke, T., Deuschl, G., Egberts, J. D., Becker, T., Fritscher‐Ravens, A., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.018 · Cited by 139 · see citing works

Parallel manifestations of neuropathologies in the enteric and central nervous systems

Natale, G., Pasquali, L., Paparelli, A., & Fornai, F. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01794.x · Cited by 69 · see citing works

The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease

Iwai, A., Masliah, E., Sundsmo, M. P., DeTeresa, R. M., Mallory, M. E., Salmon, D. P., & Saitoh, T. (1996) · Brain Research · doi:10.1016/0006-8993(96)00014-5 · Cited by 52 · see citing works

Autonomic dysfunction in Parkinson's disease

Pfeiffer, R. F. (2012) · Expert Review of Neurotherapeutics · doi:10.1586/ern.12.17 · Cited by 41 · see citing works

α-Synuclein, Aβ and Alzheimer's disease

Wirths, O. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00339-1 · Cited by 38 · see citing works

Parkinson's disease

Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,412 · see citing works

Gastrointestinal Dysfunction in Parkinson’s Disease

Fasano, A., Visanji, N. P., Liu, L. W. C., Lang, A. E., & Pfeiffer, R. F. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00007-1 · Cited by 1,016 · see citing works

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629 · see citing works

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson’s disease pathogenesis?

Houser, M. C., & Tansey, M. G. (2017) · npj Parkinson's Disease · doi:10.1038/s41531-016-0002-0 · Cited by 588 · see citing works

Autonomic dysfunction in Parkinson’s disease: Implications for pathophysiology, diagnosis, and treatment

Chen, Z., Li, G., & Liu, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104700 · Cited by 364 · see citing works

Multiple organ involvement by alpha-synuclein pathology in lewy body disorders

Gelpi, E., Navarro‐Otano, J., Tolosa, E., Gaig, C., Compta, Y., Rey, M. J., Martí, M. J., Hernández, I., Valldeoriola, F., Reñé, R., et al. (2014) · Movement Disorders · doi:10.1002/mds.25776 · Cited by 361 · see citing works

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

Hilton, D., Stephens, M., Kirk, L., Edwards, P., Potter, R., Zajicek, J., Broughton, E., Hagan, H., & Carroll, C. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1214-6 · Cited by 345 · see citing works

The Gut-Brain Axis in Parkinson’s Disease: Possibilities for Food-Based Therapies

Perez-Pardo, P., Kliest, T., Dodiya, H. B., Broersen, L. M., Garssen, J., Keshavarzian, A., & Kraneveld, A. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.05.042 · Cited by 203 · see citing works

Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities

Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 198 · see citing works

Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease

Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works

Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

Choi, J. G., Kim, N., Ju, I. G., Eo, H., Lim, S.-M., Jang, S.-E., Kim, D.-H., & Oh, M. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-19646-x · Cited by 170 · see citing works

Lactobacillus Plantarum PS128 Alleviates Neurodegenerative Progression in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Mouse Models of Parkinson’s Disease

Liao, J.-F., Cheng, Y.-F., You, S.-T., Kuo, W.-C., Huang, C.-W., Chiou, J.-J., Hsu, C.-C., Hsieh-Li, H.-M., Wang, S., & Tsai, Y.-C. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.036 · Cited by 159 · see citing works

Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review

Nair, A. T., Ramachandran, V., Joghee, N. M., Shanish Antony, A., & Ramalingam, G. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17105 · Cited by 156 · see citing works

Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration

Raimondi, I., Izzo, L., Tunesi, M., Comar, M., Albani, D., & Giordano, C. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00435 · Cited by 147 · see citing works

Enteric nervous system α-synuclein immunoreactivity in idiopathic REM sleep behavior disorder

Sprenger, F., Stefanova, N., Gelpí, E., Seppi, K., Navarro‐Otano, J., Offner, F. A., Vilas, D., Valldeoriola, F., Pont‐Sunyer, C., Aldecoa, I., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002126 · Cited by 146 · see citing works

Colonic mucosal α-synuclein lacks specificity as a biomarker for Parkinson disease

Visanji, N. P., Marras, C., Kern, D. S., AlDakheel, A., Gao, A. F., Liu, L. W. C., Lang, A. E., & Hazrati, L. (2015) · Neurology · doi:10.1212/wnl.0000000000001240 · Cited by 142 · see citing works

Alpha‐synuclein in the appendiceal mucosa of neurologically intact subjects

Gray, M. T., Muñoz, D. G., Gray, D. A., Schlossmacher, M. G., & Woulfe, J. (2013) · Movement Disorders · doi:10.1002/mds.25779 · Cited by 132 · see citing works

Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough

Ganguly, U., Singh, S., Pal, S., Prasad, S., Agrawal, B. K., Saini, R. V., & Chakrabarti, S. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.702639 · Cited by 132 · see citing works

Genetic and Environmental Factors in P arkinson's Disease Converge on Immune Function and Inflammation

Kline, E. M., Houser, M. C., Herrick, M. K., Seibler, P., Klein, C., West, A. B., & Tansey, M. G. (2020) · Movement Disorders · doi:10.1002/mds.28411 · Cited by 131 · see citing works

Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments

Poirier, A.-A., Aubé, B., Côté, M., Morin, N., Di Paolo, T., & Soulet, D. (2016) · Parkinson s Disease · doi:10.1155/2016/6762528 · Cited by 130 · see citing works

The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

Ambrosini, Y. M., Borcherding, D. C., Kanthasamy, A., Kim, H. J., Willette, A., Jergens, A., Allenspach, K., & Mochel, J. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00130 · Cited by 116 · see citing works

Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease

Barrenschee, M., Zorenkov, D., Bottner, M. B., Lange, C., Cossais, F., Scharf, A., Deuschl, G., Schneider, S. A., Ellrichmann, M., Fritscher‐Ravens, A., et al. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0408-2 · Cited by 115 · see citing works

Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease

Chiang, H., & Lin, C. (2019) · Journal of Movement Disorders · doi:10.14802/jmd.18067 · Cited by 104 · see citing works

TLR2 and TLR4 in Parkinson’s disease pathogenesis: The environment takes a toll on the gut

Gorecki, A. M., Anyaegbu, C. C., & Anderton, R. S. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00271-0 · Cited by 103 · see citing works

Can we use peripheral tissue biopsies to diagnose Parkinson's disease? A review of the literature

Schneider, S. A., Bottner, M. B., Alexoudi, A., Zorenkov, D., Deuschl, G., & Wedel, T. (2015) · European Journal of Neurology · doi:10.1111/ene.12753 · Cited by 102 · see citing works

Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms

Cury, R. G., Galhardoni, R., Fonoff, E. T., Perez‐Lloret, S., Ghilardi, M. G. D. S., Barbosa, E. R., Teixeira, M. J., & de Andrade, D. C. (2015) · European Journal of Pain · doi:10.1002/ejp.745 · Cited by 100 · see citing works

Multicenter Assessment of Immunohistochemical Methods for Pathological Alpha-Synuclein in Sigmoid Colon of Autopsied Parkinson’s Disease and Control Subjects

Beach, T. G., Corbillé, A.-G., Letournel, F., Kordower, J. H., Kremer, T., Muñoz, D. G., Intorcia, A. J., Hentz, J. G., Adler, C. H., Sue, L. I., et al. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160888 · Cited by 96 · see citing works

Alimentary, my dear Watson? The challenges of enteric α‐synuclein as a Parkinson's disease biomarker

Visanji, N. P., Marras, C., Hazrati, L., Liu, L. W. C., & Lang, A. E. (2013) · Movement Disorders · doi:10.1002/mds.25789 · Cited by 87 · see citing works

Alpha‐synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker

Chung, S. J., Kim, J., Lee, H. J., Ryu, H., Kim, K., Lee, J. H., Jung, K. W., Kim, M. J., Kim, M., Kim, Y. J., et al. (2015) · Movement Disorders · doi:10.1002/mds.26473 · Cited by 87 · see citing works

Alpha-Synuclein in Peripheral Tissues in Parkinson’s Disease

Ma, L., Liu, G.-L., Wang, D., Zhang, M., Kou, W., & Feng, T. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00383 · Cited by 86 · see citing works

Pain management in patients with Parkinson's disease: challenges and solutions

Skogar, Ö., & Lökk, J. (2016) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s105857 · Cited by 84 · see citing works

Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases

Tanei, Z., Saito, Y., Ito, S., Matsubara, T., Motoda, A., Yamazaki, M., Sakashita, Y., Kawakami, I., Ikemura, M., Tanaka, S., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02233-8 · Cited by 84 · see citing works

Evaluation of alpha-synuclein immunohistochemical methods for the detection of Lewy-type synucleinopathy in gastrointestinal biopsies

Corbillé, A.-G., Letournel, F., Kordower, J. H., Lee, J., Shanes, E. D., Neunlist, M., Muñoz, D. G., Derkinderen, P., & Beach, T. G. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0305-8 · Cited by 74 · see citing works

Clinical implications of gastric complications on levodopa treatment in Parkinson’s disease

Pfeiffer, R. F., Isaacson, S. H., & Pahwa, R. (2020) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2020.05.001 · Cited by 77 · see citing works

The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease

Lee, J. M., Derkinderen, P., Kordower, J. H., Freeman, R. L., Muñoz, D. G., Kremer, T., Zago, W. M., Hutten, S. J., Adler, C. H., Serrano, G. E., et al. (2017) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw103 · Cited by 72 · see citing works

The pathomechanisms underlying Parkinson's disease

Jellinger, K. A. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.877842 · Cited by 69 · see citing works

Management of constipation in Parkinson’s disease

Rossi, M., Merello, M., & Perez‐Lloret, S. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.997211 · Cited by 65 · see citing works

Neuroinflammation and Immune Changes in Prodromal Parkinson’s Disease and Other Synucleinopathies

Terkelsen, M. H., Klæstrup, I. H., Hvingelby, V. S., Lauritsen, J., Pavese, N., & Romero‐Ramos, M. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223245 · Cited by 63 · see citing works

G ut F eelings Ab out α‐ S ynuclein in G astrointestinal B iopsies: B iomarker in the M aking?

Ruffmann, C., & Parkkinen, L. (2016) · Movement Disorders · doi:10.1002/mds.26480 · Cited by 58 · see citing works

The role of nutrition on Parkinson’s disease: a systematic review

Bianchi, V. E., Rizzi, L., & Somaa, F. A. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2073107 · Cited by 55 · see citing works

Chronic Pain Treatment Strategies in Parkinson’s Disease

Edinoff, A. N., Sathivadivel, N., McBride, T., Parker, A., Okeagu, C. N., Kaye, A. D., Kaye, A. M., Kaye, J. S., Kaye, R. J., Sheth, M. M., et al. (2020) · Neurology International · doi:10.3390/neurolint12030014 · Cited by 55 · see citing works

Immunotherapy Targeting α-Synuclein, with Relevance for Future Treatment of Parkinson‘s Disease and Other Lewy Body Disorders

Lindström, V., Ihse, E., Fagerqvist, T., Bergström, J. J. E., Nordström, E. K. L., Möller, C., Lannfelt, L., & Ingelsson, M. (2014) · Immunotherapy · doi:10.2217/imt.13.162 · Cited by 54 · see citing works

Microbes Tickling Your Tummy: the Importance of the Gut-Brain Axis in Parkinson’s Disease

Perez‐Pardo, P., Hartog, M., Garssen, J., & Kraneveld, A. D. (2017) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-017-0129-2 · Cited by 52 · see citing works

Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease

Ruffmann, C., Bengoa‐Vergniory, N., Poggiolini, I., Ritchie, D. L., Hu, M. T., Alegre‐Abarrategui, J., & Parkkinen, L. (2018) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12486 · Cited by 51 · see citing works

Early and persistent expression of phosphorylated α-synuclein in the enteric nervous system of A53T mutant human α-synuclein transgenic mice

Bencsik, A., Muselli, L., Leboidre, M., Lakhdar, L., & Baron, T. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000137 · Cited by 48 · see citing works

Neuropathology of Nonmotor Symptoms of Parkinson's Disease

Jellinger, K. A. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.05.005 · Cited by 47 · see citing works

Peripheral and central autonomic nervous system: does the sympathetic or parasympathetic nervous system bear the brunt of the pathology during the course of sporadic PD?

Orimo, S., Ghebremedhin, E., & Gelpí, E. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2851-9 · Cited by 46 · see citing works

What Is the Evidence that Parkinson’s Disease Is a Prion Disorder, Which Originates in the Gut?

Kujawska, M., & Jodynis‐Liebert, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113573 · Cited by 46 · see citing works

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

Aldecoa, I., Navarro‐Otano, J., Stefanova, N., Sprenger, F., Seppi, K., Poewe, W. H., Cuatrecasas, M., Valldeoriola, F., Gelpí, E., & Tolosa, E. S. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.07.005 · Cited by 45 · see citing works

The relevance of pre-motor symptoms in Parkinson’s disease

Visanji, N. P., & Marras, C. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1083423 · Cited by 38 · see citing works

Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson’s disease: Comparison with surgical specimens

Shin, C., Park, S., Yun, J. Y., Shin, J. H., Yang, H., Lee, H., Kong, S., Suh, Y., Shen, G., Kim, Y. H., et al. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.09.001 · Cited by 38 · see citing works

The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease

Caligiore, D., Giocondo, F., & Silvetti, M. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.09.007 · Cited by 36 · see citing works

Relation of Enteric α-Synuclein to Gastrointestinal Dysfunction in Patients With Parkinson's Disease and in Neurologically Intact Subjects

Lee, H. J., Jung, K. W., Chung, S. J., Hong, S., Kim, J., Lee, J. H., Hwang, S. W., Ryu, H., Kim, M. J., Lee, H., et al. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm17141 · Cited by 37 · see citing works

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients

Piancone, F., Saresella, M., Rosa, F. L., Marventano, I., Meloni, M., Navarro, J., & Clerici, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.639646 · Cited by 36 · see citing works

Constipation in Parkinson’s Disease: a Nuisance or Nuanced Answer to the Pathophysiological Puzzle?

Sharma, A., Kurek, J. A., Morgan, J. C., Wakade, C. G., & Rao, S. S. C. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0609-x · Cited by 35 · see citing works

α‐Synuclein in Parkinson's Disease: From Bench to Bedside

Bellini, G., D’Antongiovanni, V., Palermo, G., Antonioli, L., Fornai, M., Ceravolo, R., Bernardini, N., Derkinderen, P., & Pellegrini, C. (2024) · Medicinal Research Reviews · doi:10.1002/med.22091 · Cited by 36 · see citing works

Diagnostic utility of gut α-synuclein in Parkinson’s disease: A systematic review and meta-analysis

Bu, J., Liu, J., Liu, K., & Wang, Z. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.039 · Cited by 33 · see citing works

Alpha-Synuclein in Peripheral Tissues as a Possible Marker for Neurological Diseases and Other Medical Conditions

Jiménez‐Jiménez, F. J., Alonso‐Navarro, H., García‐Martín, E., Santos‐García, D., Martínez-Valbuena, I., & Agúndez, J. A. G. (2023) · Biomolecules · doi:10.3390/biom13081263 · Cited by 33 · see citing works

Parkinson’s disease and colorectal cancer risk—A nested case control study

Boursi, B., Mamtani, R., Haynes, K., & Yang, Y. (2016) · Cancer Epidemiology · doi:10.1016/j.canep.2016.05.007 · Cited by 32 · see citing works

Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions

Kalampokini, S., Becker, A., Fassbender, K. C., Lyros, E., & Unger, M. M. (2019) · Parkinson s Disease · doi:10.1155/2019/7535472 · Cited by 32 · see citing works

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

Zhong, C.-B., Chen, Q.-Q., Haikal, C., Li, W., Svanbergsson, A., Diepenbroek, M., & Li, J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0179-1 · Cited by 31 · see citing works

Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls

Desmet, A.-S., Cirillo, C., Tack, J. F., Vandenberghe, W., & Berghe, P. V. (2017) · eLife · doi:10.7554/elife.26850 · Cited by 30 · see citing works

Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?

Navarro‐Zaragoza, J., Cuenca‐Bermejo, L., Almela, P., Laorden, M. L., & Herrero, M. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063038 · Cited by 30 · see citing works

Neuropathology of Parkinson’s Disease

Jellinger, K. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-08046-8_2 · Cited by 30 · see citing works

Parkinson’s Disease and the Gut: Future Perspectives for Early Diagnosis

Harsányiová, J., Buday, T., & Trancikova, A. K. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00626 · Cited by 27 · see citing works

Alpha-Synuclein in the Gastrointestinal Tract as a Potential Biomarker for Early Detection of Parkinson’s Disease

Fričová, D., Harsányiová, J., & Trancikova, A. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228666 · Cited by 26 · see citing works

Other Forms of Gastroparesis

Quigley, E. M. M. (2014) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2014.11.006 · Cited by 24 · see citing works

Alpha-Synuclein Transmission and Mitochondrial Toxicity in Primary Human Foetal Enteric Neurons In Vitro

Braidy, N., Gai, W.-P., Xu, Y. H., Sachdev, P. S., Guillemin, G. J., Jiang, X., Ballard, J. W. O., Horan, M. P., Fang, Z. M., Chong, B. H., et al. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9420-5 · Cited by 23 · see citing works

Alpha-Synuclein Accumulation and Its Phosphorylation in the Enteric Nervous System of Patients Without Neurodegeneration: An Explorative Study

Bu, L.-L., Huang, K., Zheng, D., Lin, D., Chen, Y., Jing, X., Liang, Y., & Tao, E. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.575481 · Cited by 23 · see citing works

Gut–brain axis and environmental factors in Parkinson’s disease: bidirectional link between disease onset and progression

Park, S. J., Kim, K. W., & Lee, E. J. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00994 · Cited by 23 · see citing works

Biomarkers in Prodromal Parkinson Disease: a Qualitative Review

Cooper, C. A., & Chahine, L. M. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000503 · Cited by 21 · see citing works

Single Nucleotide Polymorphisms Associated With Gut Homeostasis Influence Risk and Age-at-Onset of Parkinson's Disease

Gorecki, A. M., Bakeberg, M. C., Theunissen, F., Kenna, J. E., Hoes, M. E., Pfaff, A. L., Akkari, P. A., Dunlop, S. A., Kõks, S., Mastaglia, F. L., et al. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.603849 · Cited by 21 · see citing works

Subtle Esophageal Motility Alterations in Parkinsonian Syndromes: Synucleinopathies vs. Tauopathies

Claus, I., Suttrup, J., Muhle, P., Suntrup‐Krueger, S., Siemer, M., Lenze, F., Dziewas, R., & Warnecke, T. (2018) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12616 · Cited by 20 · see citing works

What Is Our Understanding of the Influence of Gut Microbiota on the Pathophysiology of Parkinson’s Disease?

Hill, A. E., Wade‐Martins, R., & Burnet, P. W. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.708587 · Cited by 19 · see citing works

Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System

Preterre, C., Corbillé, A.-G., Balloy, G., Letournel, F., Neunlist, M., & Derkinderen, P. (2015) · Journal of Parkinson s Disease · doi:10.3233/jpd-150670 · Cited by 18 · see citing works

α-Synuclein in the colon and premotor markers of Parkinson disease in neurologically normal subjects

Kim, J., Park, I.-S., Park, H.-E., Kim, S., Yun, J. A., Jung, C. K., Sung, H.-Y., Lee, J., & Kang, W. K. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2745-0 · Cited by 18 · see citing works

Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults

Wang, X., Liu, F., Bi, Y., Shen, X., Xu, W., Wang, J., Tan, L., & Yu, J. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51204 · Cited by 18 · see citing works

Dysautonomia in Parkinson’s Disease: Impact of Glucocerebrosidase Gene Mutations on Cardiovascular Autonomic Control

Carandina, A., Lazzeri, G., Rodrigues, G. D., Franco, G., Monfrini, E., Arienti, F., Frattini, E., Trezzi, I., Soares, P. P. D. S., Bellocchi, C., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.842498 · Cited by 18 · see citing works

Parkinson Disease and the Gut: A Primer for Gastroenterologists

Sharma, A., Voigt, R. M., Goetz, C. G., & Keshavarzian, A. (2025) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003508 · Cited by 16 · see citing works

Pain-motor integration in the primary motor cortex in Parkinson's disease

Suppa, A., Leone, C. M., Stasio, F. D., Marsili, L., Santo, A. D., Biasiotta, A., Cesa, S. L., Truini, A., Cruccu, G., & Berardelli, A. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.04.130 · Cited by 16 · see citing works

A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson’s disease

Wang, R., Pang, S., Li, J., Li, C.-L., Liu, J.-M., Wang, Y., Chen, M., & Li, Y. (2023) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-023-04520-1 · Cited by 16 · see citing works

Biofilm proficient Bacillus subtilis prevents neurodegeneration in Caenorhabditis elegans Parkinson’s disease models via PMK-1/p38 MAPK and SKN-1/Nrf2 signaling

Francisco, M., & Grau, R. R. (2025) · Scientific Reports · doi:10.1038/s41598-025-93737-4 · Cited by 15 · see citing works

Mini review: linkage between α-Synuclein protein and cognition

Saleh, H., Saleh, A. A., Yao, H., Cui, J., Shen, Y., & Li, R. (2015) · Translational Neurodegeneration · doi:10.1186/s40035-015-0026-0 · Cited by 15 · see citing works

Self‐administration of methamphetamine alters gut biomarkers of toxicity

Flack, A., Persons, A. L., Kousik, S. M., Napier, T. C., & Moszczyńska, A. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13630 · Cited by 14 · see citing works

Double‐Blind , Randomized, Placebo‐Controlled Trial of DA ‐9701 in Parkinson's Disease: PASS ‐ GI Study

Choi, J., Lee, J., Cho, J. W., Koh, S., Yang, Y. S., Yoo, D., Shin, C., & Kim, H.-T. (2020) · Movement Disorders · doi:10.1002/mds.28219 · Cited by 13 · see citing works

Association between Decreased SGK1 and Increased Intestinal α-Synuclein in an MPTP Mouse Model of Parkinson’s Disease

Seo, M. H., Kwon, D., Kim, S.-H., & Yeo, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216408 · Cited by 12 · see citing works

“Janus-Faced” α-Synuclein: Role in Parkinson’s Disease

Ray, B., Mahalakshmi, A. M., Tuladhar, S., Bhat, A., Srinivasan, A., Pellegrino, C., Kannan, A., Bolla, S. R., Chidambaram, S. B., & Sakharkar, M. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673395 · Cited by 13 · see citing works

Enhanced Contractive Tension and Upregulated Muscarinic Receptor 2/3 in Colorectum Contribute to Constipation in 6-Hydroxydopamine-Induced Parkinson’s Disease Rats

Zhang, X.-L., Zhang, X.-H., Xiao, Y., Zheng, L., Feng, X., Liu, C., Quan, Z., Zhang, Y., & Zhu, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.770841 · Cited by 12 · see citing works

Patients with Parkinson’s disease predict a lower incidence of colorectal cancer

Fang, H., Du, Y., Pan, S., Zhong, M., & Tang, J. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02497-z · Cited by 11 · see citing works

Donepezil for Constipation in Lewy Body Diseases: Four Case Studies

Lepkowsky, C. M. (2017) · Activitas Nervosa Superior · doi:10.1007/s41470-017-0004-1 · Cited by 9 · see citing works

Assessment of gastrointestinal function and enteric nervous system changes over time in the A53T mouse model of Parkinson’s disease

Han, M. N., Natale, M. R. D., Lei, E., Furness, J. B., Finkelstein, D. I., Hao, M. M., Diwakarla, S., & McQuade, R. M. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-01956-7 · Cited by 8 · see citing works

The interrelationship between intestinal immune cells and enteric α-synuclein in the progression of Parkinson’s disease

Cheng, Y.-K., & Chiang, H.-S. (2025) · Neurological Sciences · doi:10.1007/s10072-025-08114-w · Cited by 8 · see citing works

Synuclein and Parkinson’s Disease: An Update

Jellinger, K. A. (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849737357-00175 · Cited by 8 · see citing works

Neuropathology of dementia

Kim, E.-J., Vatsavayai, S., & Seeley, W. W. (2016) · The Behavioral Neurology of Dementia · doi:10.1017/9781139924771.008 · Cited by 7 · see citing works

Autonomic nervous system dysregulation in neurodegenerative diseases: Bridging brain and heart

Singh, S., Singh, D., Ansari, A. H., & Singh, S. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.04.010 · Cited by 6 · see citing works

Examination of Abnormal Alpha-synuclein Aggregates in the Enteric Neural Plexus in Patients with Ulcerative Colitis

Gibo, N., Hamaguchi, T., Miki, Y., Yamamura, T., Nakaguro, M., Ito, M., Nakamuara, M., Kawashima, H., Hirayama, M., Hirooka, Y., et al. (2022) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-4313 · Cited by 6 · see citing works

Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson’s Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation

Heß, T., Themann, P., Oehlwein, C., & Milani, T. L. (2023) · Brain Sciences · doi:10.3390/brainsci13121681 · Cited by 5 · see citing works

Immunotherapeutic interventions in Parkinson's disease: Focus on α-Synuclein

Ganguly, U., Singh, S., Chakrabarti, S., Saini, A. K., & Saini, R. V. (2022) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.11.010 · Cited by 6 · see citing works

Gastrointestinal Biopsy Obtained During Cancer Screening, a Biological Marker for α-Synucleinopathy?

Jotanovic, J., Milin-Lazovic, J. S., & Alafuzoff, I. I. (2022) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlac023 · Cited by 5 · see citing works

Gut Microbes in Parkinson's Disease

Markidi, A., Elford, J. D., Berkers, C. R., Kraneveld, A. D., & Perez‐Pardo, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00002-3 · Cited by 4 · see citing works

Alpha- synuclein immunoreactivity in the enteric nervous system of human small intestine

Casini, A., Chirletti, P., & Vaccaro, R. (2018) · IRIS Research product catalog (Sapienza University of Rome)

Expression of alpha‐synuclein (AS) in autonomic neurons is increased in Parkinson's disease (PD)

Muñoz, D. G., & Gold, A. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.58.9 · Cited by 1 · see citing works

Characterization of the Expression and Pathogenicity of Alpha-Synuclein in the Enteric Nervous System

Kintrup, C. (2026) · MACAU: Open Access Repository of Kiel University (University Library Kiel)

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

Bottner, M. B., Zorenkov, D., Hellwig, I., Barrenschee, M., Harde, J., Fricke, T., Deuschl, G., Egberts, J. D., Becker, T., Fritscher‐Ravens, A., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.07.018 · Cited by 139 · see citing works

Enteric Pathologic Manifestations of Alpha-Synucleinopathies

Punsoni, M., Friedman, J. H., Resnick, M. B., Donahue, J. E., Yang, D., & Stopa, E. G. (2017) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000613 · Cited by 15 · see citing works