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Cited by 40Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Serum and Peritoneal Fluid Immunological Markers in Adolescent Girls With Chronic Pelvic Pain

Drosdzol-Cop, Agnieszka, Skrzypulec-Plinta, Violetta, Stojko, Rafał·2012·Obstetrical & Gynecological Survey
DOI 10.1097/ogx.0b013e31825cb12b
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Abstract

The aim of this study was to determine serum and peritoneal interleukin (IL)-2, IL-4, and monocyte chemotactic protein-1 levels as diagnostic markers of endometriosis in adolescent girls. The design of the study encompassed 50 adolescent girls, aged 13 to 19 years after menarche, with chronic pelvic pain who qualified for diagnostic laparoscopy. The patients were allocated into 2 groups: group I (endometriosis) consisted of subjects with diagnosed endometriosis (n = 33, 66%) and group II (control) whose laparoscopic examinations revealed no evidence of endometriosis (n = 17, 34%). IL-2, IL-4, and Monocyte chemotactic protein 1 concentrations in serum and peritoneal samples were assessed using commercially available human enzyme-linked immunosorbent assay kits. The results were analyzed statistically with the Statistica 8.0 computer software. The value of P < 0.05 was the level of statistical significance. The results in adolescents with endometriosis had significantly higher concentrations of serum IL-4 (3.90 ± 1.58 pg/mL vs. 3.04 ± 1.72 pg/mL; P = 0.04) and peritoneal fluid IL-4 (5.03 ± 8.92 pg/mL vs. 2.74 ± 1.11 pg/mL; P = 0.03), and lower peritoneal fluid IL-2 (92.44 ± 292.75 pg/mL vs. 174.23 ± 389.77 pg/mL; P = 0.01) compared with the control. In a receiver-operating characteristic analysis, serum IL-4 as well as peritoneal fluid IL-2 and IL-4 provided the best discriminative ability between subjects with endometriosis and controls. Using cutoff points for serum IL-4 (3.00 pg/mL), peritoneal fluid IL-2 (21.00 pg/mL) and IL-4 (2.7 pg/mL), relatively high odd ratios were obtained in the prediction of endometriosis in adolescents (3.2; 6.4; 3.3). The Serum IL-4, peritoneal IL-2 and IL-4 provided a good method of discrimination between subjects with endometriosis and controls. Target Audience: Obstetricians & Gynecologists, Family Physicians Learning Objectives: After completion of this educational activity, the reader will be able to Analyze the prevalence and clinical presentation of endometriosis in adolescents, which is significantly different from typical symptomatology observed in adult women. Assess the role of serum and peritoneal fluid IL-2, IL-4, and MCP-1 levels as diagnostic markers of endometriosis in adolescent girls. Use the cutoff value of serum IL-4 as well as peritoneal fluid IL-2 and IL-4 levels as the discrimination method between subjects with endometriosis and controls.

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  • Significantly increased IL-4 serum values have been found in adolescents with endometriosis.

    “Significantly increased IL-4 serum values have been found in adolescents with endometriosis [52].”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [52]

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Authors
Drosdzol-Cop, A., Skrzypulec-Plinta, V., & Stojko, R.
Affiliations
Medical University of Silesia (PL)
Corresponding author
Drosdzol-Cop, Agnieszka
ORCID
Venue
Obstetrical & Gynecological Survey
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-06
Volume
67
Issue
6
Pages
374-381
ISSN
0029-7828 (ISSN-L)
DOI
10.1097/ogx.0b013e31825cb12b
OpenAlex
W1979868320
Cited by
40
References
23
Citations by year
2026: 2 · 2025: 1 · 2024: 8 · 2023: 2 · 2022: 4 · 2021: 3 · 2019: 2 · 2018: 4 · 2016: 6 · 2015: 3 · 2013: 5
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Obstetrical & Gynecological Survey (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, chronic pelvic pain, adolescent girls, interleukin-2, IL-4, MCP-1, serum biomarkers, diagnostic biomarkers, diagnostic accuracy, immunological markers, diagnostic laparoscopy, dysmenorrhea, dyspareunia
MeSH terms
Adolescent, Ascitic Fluid, Endometriosis, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interleukin-2, Laparoscopy, Preoperative Care, ROC Curve, Reproducibility of Results, Biomarkers, Interleukin-4, Pelvic Pain, Chemokine CCL2, Serum, Young Adult, Chronic Pain

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