Cited by 88Endometriosis Research and TreatmentEctopic Pregnancy Diagnosis and ManagementGynecological conditions and treatments

Combination of CCR1 mRNA, MCP1, and CA125 Measurements in Peripheral Blood as a Diagnostic Test for Endometriosis

Agic, Admir, Djalali, Schima, Wolfler, Monika M., Halis, Gulden, Diedrich, Klaus, Hornung, Daniela·2008·Reproductive Sciences

Abstract

This study investigated the possible use of CCR1 mRNA measurement in peripheral blood leukocytes in combination with measurements of monocyte chemotactic protein-1 (MCP-1) and CA125 protein in serum as a diagnostic test for endometriosis.The expression of CCR1 mRNA in peripheral blood leukocytes was measured by quantitative real-time polymerase chain reaction. MCP-1 and CA125 levels in serum were determined by ELISA and ECLIA.The ratio of CCR1/HPRT mRNA in peripheral blood of patients with endometriosis and adenomyosis was significantly elevated compared with women without endometriosis. Additionally, serum levels of MCP-1 and CA125 were significantly higher in patients with endometriosis. This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis.

Integrity signals

Registry

Crossref · 10.1177/1933719108318598

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A panel of CA-125, CCR type-1 mRNA, and MCP-1 showed sensitivity of 92.2% and specificity of 81.6% to detect endometriosis.

    “A panel of CA-125, chemokine receptor (CCR) type-1 mRNA, and monocyte chemoattractant protein- (MCP) 1 showed a sensitivity of 92.2% and specificity of 81.6% to detect endometriosis [40].”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [40]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Agic, A., Djalali, S., Wolfler, M. M., Halis, G., Diedrich, K., & Hornung, D.
Affiliations
University of Lübeck (DE)
Corresponding author
Hornung, Daniela
Venue
Reproductive Sciences
Published
2008-11
Volume
15
Issue
9
Pages
906-911
ISSN
  • 1933-7191 (ISSN-L)
  • 1933-7205
OpenAlex
W1991956657
Cited by
88
References
27
Citations by year
2025: 4 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 4
FWCI
7.72
Type
journal article
Language
en
Open access
closed
Locations
  • Reproductive Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Keywords
endometriosis, MCP-1, CA125, peripheral blood leukocytes, adenomyosis, diagnostic biomarkers, serum biomarkers, diagnostic accuracy
MeSH terms
Endometriosis, Female, Humans, Retrospective Studies, RNA, Messenger, CA-125 Antigen, Chemokine CCL2, Receptors, CCR1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review