Combination of CCR1 mRNA, MCP1, and CA125 Measurements in Peripheral Blood as a Diagnostic Test for Endometriosis
Abstract
This study investigated the possible use of CCR1 mRNA measurement in peripheral blood leukocytes in combination with measurements of monocyte chemotactic protein-1 (MCP-1) and CA125 protein in serum as a diagnostic test for endometriosis.The expression of CCR1 mRNA in peripheral blood leukocytes was measured by quantitative real-time polymerase chain reaction. MCP-1 and CA125 levels in serum were determined by ELISA and ECLIA.The ratio of CCR1/HPRT mRNA in peripheral blood of patients with endometriosis and adenomyosis was significantly elevated compared with women without endometriosis. Additionally, serum levels of MCP-1 and CA125 were significantly higher in patients with endometriosis. This method showed a sensitivity of 92.2%, a specificity of 81.6%, a negative predictive value of 83.3%, a positive predictive value of 92.3%, a likelihood ratio of a positive test result of 5.017, and a likelihood ratio of a negative test result of 0.096 to predict the presence or absence of endometriosis.The results imply the potential use of CCR1 mRNA, MCP-1, and CA125 protein measurements for the diagnosis or exclusion of endometriosis.
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A panel of CA-125, CCR type-1 mRNA, and MCP-1 showed sensitivity of 92.2% and specificity of 81.6% to detect endometriosis.
“A panel of CA-125, chemokine receptor (CCR) type-1 mRNA, and monocyte chemoattractant protein- (MCP) 1 showed a sensitivity of 92.2% and specificity of 81.6% to detect endometriosis [40].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [40]
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Evaluation of YB-1 levels in patients with endometriosis
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Self-citationInflammation and Endometriosis
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Peripheral Blood Biomarkers for Endometriosis
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- Authors
- Agic, A., Djalali, S., Wolfler, M. M., Halis, G., Diedrich, K., & Hornung, D.
- Affiliations
- University of Lübeck (DE)
- Corresponding author
- Hornung, Daniela
- ORCID
- Hornung, Daniela
- Venue
- Reproductive Sciences
- Published
- 2008-11
- Volume
- 15
- Issue
- 9
- Pages
- 906-911
- ISSN
- 1933-7191 (ISSN-L)
- 1933-7205
- OpenAlex
- W1991956657
- Cited by
- 88
- References
- 27
- Citations by year
- 2025: 4 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 4
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive Sciences (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, MCP-1, CA125, peripheral blood leukocytes, adenomyosis, diagnostic biomarkers, serum biomarkers, diagnostic accuracy
- MeSH terms
- Endometriosis, Female, Humans, Retrospective Studies, RNA, Messenger, CA-125 Antigen, Chemokine CCL2, Receptors, CCR1
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