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Cited by 46Health, psychology, and well-beingPsychological Well-being and Life SatisfactionHealth disparities and outcomes

Well-Being and Chronic Disease Incidence: The English Longitudinal Study of Ageing

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Okely, Judith A., Gale, Catharine R.·2016·Psychosomatic Medicine
DOI 10.1097/psy.0000000000000279PMC PMC4819773
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Abstract

BACKGROUND: Previous research suggests that greater well-being may protect against onset of chronic disease. However, it is unclear whether this association is similar across different types of disease. METHOD: We used Cox proportional hazards regression to examine the prospective relationship between well-being (measured using the CASP-19 quality of life questionnaire) and incidence of arthritis, cancer, stroke, diabetes, myocardial infarction, and chronic lung disease over 8 years. The sample consisted of 8182 participants 50 years or older from the English Longitudinal Study of Ageing. RESULTS: After adjustments for established risk factors, a standard deviation increase in CASP-19 score was associated with a decrease in arthritis risk (hazard ratio [HR] = 0.89, 95% confidence interval [CI] = 0.83-0.96) and, in those younger than 65 years, a decrease in diabetes risk (HR = 0.82, 95% CI = 0.70-0.95) and chronic lung disease risk (HR = 0.80, 95% CI = 0.66-0.97). Higher CASP-19 scores were associated with reduced risk for stroke and myocardial infarction; however, these associations were no longer significant after adjustments for established risk factors. No association was observed for cancer incidence. An age interaction was observed for diabetes, myocardial infarction, and chronic lung disease, with a stronger association between CASP-19 score and disease incidence at younger ages. CONCLUSIONS: The extent of association between well-being and incident disease risk is not consistent across different chronic diseases. Future studies should examine the cause of this variation.

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  • High quality of life is associated with a reduced risk of T2DM over a 6-year follow-up period in participants <65 years of age.

    “A 2016 analysis of the English Longitudinal Study of Ageing found that high quality of life was associated with a reduced risk of T2DM over a 6-year follow-up period in participants who were <65 years of age 89”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [89]

    The Results report a significant inverse association between CASP-19 quality-of-life scores and incident diabetes in participants under 65; the Methods report a median follow-up of six years. However, the Methods define the outcome as a reported diagnosis of “diabetes or high blood sugar,” without identifying cases specifically as type 2 diabetes. (LLM, conf=0.88)

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  • In the ELSA cohort (n=8,182 and n=451 new cases of diabetes mellitus; median mean follow-up of 6 years), greater quality of life measured by CASP-19 was associated with decreased diabetes mellitus risk HR 0.82 (95% CI 0.70-0.95) but only in those aged <65 years.

    “ELSA ( n = 8,182 and n = 451 new cases of diabetes mellitus; median mean follow- up of 6 year) | CASP-19 quality of life scale. | ‡ Greater quality of life was associated with decreased diabetes mellitus risk HR 0.82 (95%”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Okely (2016) 83

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Authors
Okely, J. A., & Gale, C. R.
Affiliations
MRC Lifecourse Epidemiology Unit (GB)
ORCID
Okely, Judith A.
Venue
Psychosomatic Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-04
Volume
78
Issue
3
Pages
335-344
ISSN
0033-3174 (ISSN-L)
DOI
10.1097/psy.0000000000000279
PMC
PMC4819773
OpenAlex
W2336818524
Cited by
46
References
10
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 2
FWCI
6.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Psychosomatic Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Medical Research Council (MR/K026992/1, MC_UU_12011/2)
  • Biotechnology and Biological Sciences Research Council
Topics
  • Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
  • Social Sciences › Psychology › Social Psychology › Psychological Well-being and Life Satisfaction
  • Social Sciences › Health › Health disparities and outcomes
Keywords
well-being, chronic disease incidence, CASP-19, quality of life, arthritis, diabetes mellitus, stroke, myocardial infarction, chronic lung disease, cancer, age interaction, English Longitudinal Study of Ageing
MeSH terms
Aged, Aging, Arthritis, Chronic Disease, Diabetes Mellitus, England, Female, Humans, Longitudinal Studies, Lung Diseases, Male, Middle Aged, Myocardial Infarction, Neoplasms, Personal Satisfaction, Quality of Life, Incidence, Proportional Hazards Models, Stroke

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