Cited by 189Cardiac Health and Mental HealthAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychological Treatments and Assessments

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Effectiveness of Cognitive Behavioral Therapy for Depression and Anxiety in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis

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Reavell, James, Hopkinson, Michael, Clarkesmith, Danielle, Lane, Deirdre A.·2018·Psychosomatic Medicine

DOI 10.1097/psy.0000000000000626

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Abstract

OBJECTIVE: Depression and anxiety are highly prevalent in patients with cardiovascular disease (CVD) and influence their mental well-being and CVD prognosis. The primary objective was to assess the effectiveness of cognitive behavioral therapy (CBT) for depression and anxiety in patients with CVD. Secondary objectives were to assess the impact of CBT on cardiovascular mortality, cardiovascular events, patient satisfaction, and quality of life. METHODS: MEDLINE, PsycINFO, CINAHL, CENTRAL, and alternative sources were searched for randomized controlled trials and observational studies with a control. Studies were required to assess CBT in coronary heart disease, acute coronary syndrome, atrial fibrillation, or postmyocardial infarction patients, with anxiety and/or depression. Studies were independently screened by two reviewers and critically appraised using the Cochrane Risk of Bias tool. The random-effects model was used to pool standardized mean differences (SMD). RESULTS: Twelve randomized controlled trials were included. At follow-up, depression (SMD = -0.35, 95% confidence interval [CI] = -0.52 to -0.17, p < .001, I = 59%) and anxiety (SMD = -0.34, 95% CI = -0.65 to -0.03, p = .03, I = 71%) scores were significantly lower in CBT patients compared with controls. Change in mental health quality of life (SF-12) was also significantly greater for CBT patients, compared with controls (mean difference = 3.62, 95% CI = 0.22 to 7.02, p = .04, I = 0%). No differences in patient satisfaction or cardiovascular events were evident between CBT and control groups. Among the study reports included in this meta-analysis, data specific to cardiovascular mortality were not reported. CONCLUSIONS: Cognitive behavioral therapy seems to be an effective treatment for reducing depression and anxiety in patients with CVD and should be considered in standard clinical care.

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Eriksson‐Liebon, M. (2024) · Linköping University medical dissertations · doi:10.3384/9789180755597
Psychiatric Management of Patients with Cardiac Disease
Zambrano, J., Beach, S. R., Celano, C. M., Huffman, J. C., Januzzi, J. L., & Stern, T. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-11844-9.00040-0
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Shayakhmetova, E. S., Газизовна, М. Э., Рамилевна, Г. В., Аркадьевна, Ф. С., Мингазетдинова, Л. Н., KAMALTDINOVA, G. J., ASADULLINA, G. V., RUSTYAMOVA, Z. Y., Эльдусовна, Н. А., Искандаровна, С. Л., et al. (2024) · The Bulletin of Contemporary Clinical Medicine · doi:10.20969/vskm.2024.17(1).78-86
INVESTIGATION OF SOCIO-DEMOGRAPHIC FACTORS AFFECTING THE QUALITY OF LIFE AND THE ANXIETY/DEPRESSION SCORES IN THE ACUTE MYOCARDIAL INFARCTION PHASE – OBSERVATIONAL STUDY
Balla, K., & Haase, K. K. (2024) · European Journal of Public Health Studies · doi:10.46827/ejphs.v7i1.172
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ENIGMA-shock: protocol for a study framEwork for aN InteGrated assessMent of cArdiac rehabilitation programmes in patients acutely managed for cardiogenic shock
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“Estos hallazgos coinciden con investigaciones previas que han documentado la eficacia de las intervenciones psicológicas en la población cardíaca (Fernández Abascal et al. 2003, Linden et al., 1996; Reavell et al., 2018, Valls Lázaro, 2021, Moreno Monzó et al. 2024).”
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Additional file 1 of The experience of participating in an internet-based cognitive behavioral therapy program among patients with cardiovascular disease and depression: a qualitative interview study
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Effects of cognitive behavioral therapy on anxiety and depression in patients with myocardial infarction: a systematic review and meta-analysis
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Ackerman‐Banks, C. M., Palmsten, K. K., Lipkind, H. S., & Ahrens, K. A. (2026) · Pregnancy · doi:10.1002/pmf2.70344
“While cognitive behavioral therapy has been demonstrated to significantly reduce depression and anxiety in patients with CVD, the possible impact on cardiovascular events is mixed [43].”
Behandlung
Titscher, G., Albus, C., Boll-Klatt, A., Hilke, K., Kleinschmidt, J., Köllner, V., Princip, M., von Känel, R., Herrmann‐Lingen, C., Titscher, G., et al. (2026) · Springer eBooks · doi:10.1007/978-3-662-72956-4_8
Psychological Aspects of Pediatric and Congenital Heart Disease
Kasparian, N. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-11851-7.00083-5
Psychological–dietary interactions in chronic disease management: mechanisms and integrated intervention strategies
Liu, X., Leng, H., Li, Z., Deng, X., Tian, B., Xiao, X., & Sun, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1925415
The Joint Effect of Life's Essential 8 and Mood Disorders on Mortality: A Prospective Cohort Study from NHANES 2007–2012Preprint
Jiang, S., Zhu, J., Ji, M., Jiang, L., Fan, S., Zuo, H., & Zhang, Z. (2026) · Research Square · doi:10.21203/rs.3.rs-10627635/v1
Impacts of mindfulness- and cognitive behavior-based interventions on psychological and physiological health outcomes in females with polycystic ovary syndrome: A systematic review
Duval, A., Berbrier, D. E., Crestol, A., Schwende, B. K., Ditto, B., & Usselman, C. W. (2026) · Journal of Health Psychology · doi:10.1177/13591053261489860

Authors: Reavell, J., Hopkinson, M., Clarkesmith, D., & Lane, D. A.
Affiliations: Sandwell & West Birmingham Hospitals NHS Trust (GB)
Corresponding author: Lane, Deirdre A.
ORCID: Clarkesmith, Danielle
Lane, Deirdre A.
Venue: Psychosomatic Medicine
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-10
Volume: 80
Issue: 8
Pages: 742-753
ISSN: 0033-3174 (ISSN-L)
1534-7796
DOI: 10.1097/psy.0000000000000626
OpenAlex: W2883745162
Cited by: 189
References: 34
Citations by year: 2026: 14 · 2025: 17 · 2024: 28 · 2023: 24 · 2022: 36 · 2021: 34 · 2020: 23 · 2019: 12
FWCI: 3.22
Type: journal article
Language: en
Open access: green
vbn.aau.dk
Licence: other-oa
Locations: Psychosomatic Medicine (publishedVersion)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (submittedVersion, other-oa)
Funders: Bristol-Myers Squibb
Pfizer
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
Keywords: cognitive behavioral therapy, depression, anxiety, cardiovascular disease, coronary artery disease, acute coronary syndrome, atrial fibrillation, post-myocardial infarction, quality of life, cardiovascular mortality, cardiovascular events, patient satisfaction
MeSH terms: Anxiety Disorders, Cardiovascular Diseases, Depressive Disorder, Humans, Comorbidity, Cognitive Behavioral Therapy, Outcome Assessment, Health Care

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Effectiveness of Cognitive Behavioral Therapy for Depression and Anxiety in Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis

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