. Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort.
Open accessAbstract
OBJECTIVE: To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk. METHODS: Vital status was ascertained in 922 HIV-infected participants from the Study of Fat Redistribution and Metabolic Change in HIV infection. Multivariable logistic regression estimated odds ratios after adjustment for demographic, cardiovascular, and HIV-related factors. RESULTS: Over a 5-year period, HIV-infected participants with fibrinogen levels in the highest tertile (>406 mg/dL) had 2.6-fold higher adjusted odds of death than those with fibrinogen in the lowest tertile (<319 mg/dL). Those with high CRP (>3 mg/L) had 2.7-fold higher adjusted odds of death than those with CRP <1 mg/L. When stratified by CD4 count category, fibrinogen (as a linear variable) remained independently associated [odds ratio (95% confidence intervals)] per 100 mg/dL increase in fibrinogen: 1.93 (1.57 to 2.37); 1.43 (1.14 to 1.79); 1.43 (1.14 to 1.81); and 1.30 (1.04 to 1.63) for CD4 <200, 200-350, >350 to 500, and >500 cells per microliter, respectively. Higher CRP also remained associated with higher odds of death overall and within each CD4 subgroup. CONCLUSIONS: Fibrinogen and CRP are strong and independent predictors of mortality in HIV-infected adults. Our findings suggest that even in those with relatively preserved CD4 counts >500 cells per microliter, inflammation remains an important risk factor for mortality. Further investigation should determine whether interventions to reduce inflammation might decrease mortality risk in HIV-infected individuals.
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The ability of these biomarkers to predict outcome has been observed in most patient populations, including those with preserved immune function.
“The ability of these biomarkers to predict outcome has been observed in most patient populations, including those with preserved immune function (51).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [51]
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Role of T‐Cell Dysfunction, Inflammation, and Coagulation in Microvascular Disease in HIV
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Opioids Impair Intestinal Epithelial Repair in HIV-Infected Humanized Mice
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Cardiovascular Complications of HIV in Endemic Countries
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FRAILTY AND PRE-FRAILTY IN A CONTEMPORARY COHORT OF HIV-INFECTED ADULTS
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- Authors
- Tien, P. C., Choi, A. I., Zolopa, A. R., Benson, C., Tracy, R., Scherzer, R., Bacchetti, P., Shlipak, M., & Grunfeld, C.
- Affiliations
- San Francisco VA Medical Center (US)
- Stanford Medicine (US)
- University of California San Diego (US)
- University of California, San Francisco (US)
- Corresponding author
- Tien, Phyllis C
- Choi, Andy I
- Scherzer, Rebecca
- Shlipak, Michael
- ORCID
- Venue
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2010-11-01
- Volume
- 55
- Issue
- 3
- Pages
- 316-322
- ISSN
- 1525-4135 (ISSN-L)
- PMC
- PMC2955817
- OpenAlex
- W2046166857
- Cited by
- 279
- References
- 28
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 16 · 2021: 17 · 2020: 15 · 2019: 13 · 2018: 18 · 2017: 21 · 2016: 26 · 2015: 23 · 2014: 24 · 2013: 31 · 2012: 25
- FWCI
- 25.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAIDS Journal of Acquired Immune Deficiency Syndromes (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2m01rr000083-41)
- National Heart, Lung, and Blood Institute (HL-53359, R01HL053359, HL-74814, R01HL074814)
- National Institute of Allergy and Infectious Diseases (K23AI066943)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK080645, R01DK057508, K23DK080645)
- National Center for Research Resources (RR00054, UL1RR024131, RR-00051, RR 0636, M01RR000054, M01RR000051, RR 000 52, M01RR000052, M01-RR000083, RR00865, M01RR000865, RR 00083, M01RR000036)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- HIV infection, inflammation, mortality, fibrinogen, C-reactive protein, inflammatory markers, CD4 count, mortality risk factors
- MeSH terms
- Adult, C-Reactive Protein, Female, Fibrinogen, Humans, Inflammation, Male, Middle Aged, Prognosis, HIV Infections, Survival Analysis, CD4 Lymphocyte Count
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