The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Gut Hormones as Mediators of Appetite and Weight Loss After Roux-en-Y Gastric Bypass
Abstract
In Brief Objective: To evaluate the physiologic importance of the satiety gut hormones. Background: Controversy surrounds the physiologic role of gut hormones in the control of appetite. Bariatric surgery remains the most effective treatment option for obesity, and gut hormones are implicated in the reduction of appetite and weight after Roux-en-Y gastric bypass. Methods: We correlated peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) changes within the first week after gastric bypass with changes in appetite. We also evaluated the gut hormone responses of patients with good or poor weight loss after gastric bypass. Finally, we inhibited the gut hormone responses in gastric bypass patients and then evaluated appetite and food intake. Results: Postprandial PYY and GLP-1 profiles start rising as early as 2 days after gastric bypass (P < 0.05). Changes in appetite are evident within days after gastric bypass surgery (P < 0.05), and unlike other operations, the reduced appetite continues. However, in patients with poor weight loss after gastric bypass associated with increased appetite, the postprandial PYY and GLP-1 responses are attenuated compared with patients with good weight loss (P < 0.05). Inhibiting gut hormone responses, including PYY and GLP-1 after gastric bypass, results in return of appetite and increased food intake (P < 0.05). Conclusion: The attenuated appetite after gastric bypass is associated with elevated PYY and GLP-1 concentrations, and appetite returns when the release of gut hormones is inhibited. The results suggest a role for gut hormones in the mechanism of weight loss after gastric bypass and may have implications for the treatment of obesity. Roux-en-Y gastric bypass is an effective treatment for obesity, and gut hormones have been implicated as causing reduction of appetite and weight. We showed that significant weight loss depends on gut hormone concentrations and that attenuated appetite after gastric bypass is associated with increased gut hormones, and appetite returns when the release of gut hormones is inhibited.
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“GB subjects have elevated plasma concentrations of GLP-1 (6,8–13).”
From Gastric Bypass Surgery Enhances Glucagon-Like Peptide 1–Stimulated Postprandial Insulin Secretion in Humans (2011) · cites this paper as [10]
In the citing paper
“Genetic factors [8], increases in gut hormones such as glucagon-like-peptide-1 (GLP-1) and peptide YY (PYY) [9], and decreases in the production of ghrelin play an important role in appetite regulation and post-surgical weight outcomes [10].”
From Patients' Experiences of Weight Regain After Bariatric Surgery (2022) · cites this paper as [9]
Citations
Cites
Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery
Sjöström, L., Lindroos, A.-K., Peltonen, M., Torgerson, J., Bouchard, C., Carlsson, B., Dahlgren, S., Larsson, B., Narbro, K., Sjöström, C. D., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035622 · Cited by 4,457
Ghrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Self-citationPories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293
Glucagon-like peptide-1 7–36: a physiological incretin in man
Kreymann, B., Ghatei, M. A., Williams, G., & Bloom, S. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91194-9 · Cited by 1,928
Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604
Self-citationAnaesthesia, surgery, and challenges in postoperative recovery
Kehlet, H., & Dahl, J. B. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14966-5 · Cited by 1,449
Human distribution and release of a putative new gut hormone, peptide YY
Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985
Self-citationWeight Gain After Short- and Long-Limb Gastric Bypass in Patients Followed for Longer Than 10 Years
Christou, N. V., Look, D., & MacLean, L. D. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000217592.04061.d5 · Cited by 727
Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety
le Roux, C. W., Batterham, R. L., Aylwin, S. J. B., Patterson, M., Borg, C.-M., Wynne, K., Kent, A. S. H., Vincent, R. P., Gardiner, J., Ghatei, M. A., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0972 · Cited by 562
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
Näslund, E., Barkeling, B., King, N., Gutniak, M., Blundell, J., Holst, J., Rössner, S., & Hellström, P. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800818 · Cited by 468
Challis, B., Coll, A. P., Yeo, G. S. H., Pinnock, S. B., Dickson, S. L., Thresher, R. R., Dixon, J. B., Zahn, D., Rochford, J. J., White, A. E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306931101 · Cited by 376
Peptide YY3–36 and Glucagon-Like Peptide-17–36 Inhibit Food Intake Additively
Neary, N. M., Small, C. J., Druce, M. R., Park, A. J., Ellis, S. M., Semjonous, N. M., Dakin, C. L., Filipsson, K., Wang, F., Kent, A. S., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0237 · Cited by 371
Savage, A. P., Adrian, T. E., Carolan‐Rees, G., Chatterjee, K., & Bloom, S. R. (1987) · Gut · doi:10.1136/gut.28.2.166 · Cited by 338
Borg, C.-M., le Roux, C. W., Ghatei, M. A., Bloom, S. R., Patel, A. G., & Aylwin, S. J. B. (2006) · British journal of surgery · doi:10.1002/bjs.5227 · Cited by 325
Distribution and release of human pancreatic polypeptide.
Adrian, T. E., Bloom, S. R., Bryant, M. G., Polak, J. M., Heitz, P., & Barnes, A. (1976) · Gut · doi:10.1136/gut.17.12.940 · Cited by 313
Laparoscopic Roux-en-Y Gastric Bypass: Technique and 3-Year Follow-Up
Higa, K. D., Ho, T., & Boone, K. B. (2001) · Journal of Laparoendoscopic & Advanced Surgical Techniques · doi:10.1089/10926420152761905 · Cited by 287
Peptide YY3–36Inhibits Food Intake in Mice through a Melanocortin-4 Receptor-Independent Mechanism
Halatchev, I. G., Ellacott, K. L. J., Fan, W., & Cone, R. D. (2004) · Endocrinology · doi:10.1210/en.2003-1754 · Cited by 237
Intravenous Infusion of Peptide YY(3–36) Potently Inhibits Food Intake in Rats
Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2004) · Endocrinology · doi:10.1210/en.2004-1138 · Cited by 236
Dixon, A. F. R., Dixon, J. B., & O’Brien, P. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1546 · Cited by 228
Effects of PYY[3–36] in rodent models of diabetes and obesity
Pittner, R. A., Moore, C. X., Bhavsar, S., Gedulin, B. R., Smith, P. A., Jodka, C. M., Parkes, D. G., Paterniti, J. R., Srivastava, V. P., & Young, A. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802696 · Cited by 223
Changes in eating behavior after horizontal gastroplasty and Roux-en-Y gastric bypass
Kenler, H. A., Brolin, R. E., & Cody, R. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.1.87 · Cited by 201
Characterization of Ghrelin-Like Immunoreactivity in Human Plasma
Patterson, M., Murphy, K. G., le Roux, C. W., Ghatei, M. A., & Bloom, S. R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1641 · Cited by 180
Peptide YY abnormalities in gastrointestinal diseases
Adrian, T. E., Savage, A. P., Bacarese-Hamilton, A. J., Wolfe, K., Besterman, H. S., & Bloom, S. R. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90936-4 · Cited by 175
Independent influences of body mass and gastric volumes on satiation in humans
Delgado-Aros, S., Cremonini, F., Castillo, J. E., Chial, H. J., Burton, D. D., Ferber, I., & Camilleri, M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.007 · Cited by 163
Optimizing Outcomes in Bariatric Surgery
McCarty, T. M., Arnold, D. T., Lamont, J. P., Fisher, T. L., & Kuhn, J. A. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000183354.66073.4c · Cited by 161
Riediger, T., Bothe, C., Becskei, C., & Lutz, T. A. (2004) · Neuroendocrinology · doi:10.1159/000079842 · Cited by 122
Release of peptide YY (PYY) after resection of small bowel, colon, or pancreas in man.
Adrian, T. E., Ap, S., Fuessl, H., Wolfe, K., Besterman, H. S., & Bloom, S. R. (1987) · PubMed · Cited by 117
Näslund, E. B., Melin, I., Grybäck, P., Hagg, A., Hellström, P. M., Jacobsson, H., Theodorsson, E., Rössner, S., & Bäckman, L. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.1.26 · Cited by 64
Enhancement of feeding suppression by PYY3-36 in rats with area postrema ablations
Cox, J. E., & Randich, A. (2004) · Peptides · doi:10.1016/j.peptides.2004.03.003 · Cited by 55
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Sjöström, L., Gummesson, A., Sjöström, C. D., Narbro, K., Peltonen, M., Wedel, H., Bengtsson, C., Bouchard, C., Carlsson, B., Dahlgren, S., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70159-7 · Cited by 770
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Peterli, R., Wölnerhanssen, B. K., Peters, T. T. A., Devaux, N., Kern, B. E., Christoffel-Courtin, C., Drewe, J., von Flüe, M., & Beglinger, C. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181ae32e3 · Cited by 567
Metadata
- Authors
- le Roux, C. W., Welbourn, R., Werling, M., Osborne, A., Kokkinos, A., Laurenius, A., Lönroth, H., Fändriks, L., Ghatei, M. A., Bloom, S. R., & Olbers, T.
- Affiliations
- Musgrove Park Hospital (GB)
- Sahlgrenska University Hospital (SE)
- Hammersmith Hospital (GB)
- Corresponding author
- Kokkinos, Alexander
- Ghatei, Mohammad A.
- Bloom, Stephen R.
- ORCID
- Venue
- Annals of Surgery
- Published
- 2007-11
- Volume
- 246
- Issue
- 5
- Pages
- 780-785
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2079737026
- Cited by
- 741
- References
- 31
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 28 · 2023: 25 · 2022: 28 · 2021: 49 · 2020: 36 · 2019: 38 · 2018: 35 · 2017: 38 · 2016: 53 · 2015: 61 · 2014: 49 · 2013: 45 · 2012: 63
- FWCI
- 34.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Surgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research (DHCS/05/05)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- gastrointestinal hormones, appetite regulation, Roux-en-Y gastric bypass, peptide YY, glucagon-like peptide-1, satiety, weight loss, obesity, postprandial hormone response, dietary intake, bariatric surgery
- MeSH terms
- Appetite Regulation, Female, Follow-Up Studies, Humans, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Gastric Bypass, Weight Loss, Body Mass Index, Treatment Outcome, Peptide YY, Glucagon-Like Peptide 1, Ghrelin
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