Pericytes, Microvasular Dysfunction, and Chronic Rejection
Open accessAbstract
In Brief Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Thus, there is a persistent quest for development of antichronic rejection therapies and identification of novel molecular and cellular targets. One of the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascular permeability, development, and maturation by controlling endothelial cell functions and regulating tissue fibrosis and inflammatory response. In this review, we discuss the potential of targeting pericytes in the development of microvasular dysfunction and the molecular pathways involved in regulation of pericyte activities for antichronic rejection intervention. Kloc and colleagues review the potential of targeting pericytes in microvasular dysfunction and chronic rejection, and of new therapies based on targeting the molecular pathways involved in regulation of pericyte activities.
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Pericytes, along with endothelial cells, are involved in basement membrane remodeling during angiogenesis and tumorigenesis.
“Along with endothelial cells, pericytes are involved in the basement membrane remodeling during angiogenesis [24] and tumorigenesis [25].”
From Tumor microenvironment complexity and therapeutic implications at a glance (2020) · cites this paper as [24]
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Flagged first, then by citations
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Cited by
Sorted by citations
Tumor microenvironment complexity and therapeutic implications at a glance
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“Along with endothelial cells, pericytes are involved in the basement membrane remodeling during angiogenesis [24] and tumorigenesis [25] .”
Background
- Authors
- Kloc, M., Kubiak, J. Z., Li, X. C., & Ghobrial, R. M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Houston Methodist Research Institute (US)
- Houston Methodist (US)
- Corresponding author
- Ghobrial, Rafik M.
- Venue
- Transplantation
- Published
- 2015-04
- Volume
- 99
- Issue
- 4
- Pages
- 658-667
- ISSN
- 0041-1337 (ISSN-L)
- PMC
- PMC4455035
- OpenAlex
- W1990783176
- Cited by
- 34
- References
- 125
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI 080779A2, R01AI080779)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- pericytes, chronic rejection, microvascular dysfunction, organ transplantation, antirejection therapy, microvascular permeability, endothelial cells, fibrosis, inflammation
- MeSH terms
- Animals, Cell Communication, Chronic Disease, Fibrosis, Graft Rejection, Humans, Microcirculation, Signal Transduction, Organ Transplantation, Treatment Outcome, Inflammation Mediators, Pericytes, Myocytes, Smooth Muscle, Angiogenic Proteins, Endothelial Cells, Cell Transdifferentiation, Microvessels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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