The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Anti-Human Leukocyte Antigen and Donor-Specific Antibodies Detected by Luminex Posttransplant Serve as Biomarkers for Chronic Rejection of Renal Allografts
Abstract
Background.: Although the incidence of early acute rejection could have been diminished in the past, the long-term renal allograft survival could not benefit from the introduction of more effective immunosuppressive regimens mainly aiming at cellular rejection mechanisms. The cause of chronic rejection is still discussed controversially. Here, we demonstrate to what extent human leukocyte antigen (HLA) antibodies (HLAab) posttransplant contribute to late graft outcome. Methods.: A total of 1014 deceased kidney transplant recipients transplanted at the Charité hospital were monitored in a cross-sectional manner for the development of HLAab using Luminex Single Antigen beads. Patients with stable kidney function at a median of 5-years posttransplant were tested once for HLAab and monitored for 5.5 years after testing. Results.: Thirty percent of recipients showed HLAab. Donor-specific antibodies (DSA) were found in 31% of antibody positive patients. The presence of DSA was associated with a significantly lower graft survival of 49% vs. 83% in the HLAab negative group ( P ≤0.0001). Non-DSAs also had an adverse effect on graft survival (70% vs. 83%; P =0.0001). In a prospective analysis of 195 patients with repeatedly no detectable HLAab, the survival probability was 94% as opposed to 79% survival among patients who developed HLAab de novo after the first testing ( P =0.05). Conclusions.: We confirmed that HLAab produced even late after transplantation are detrimental to graft outcome. DSA were proven to have a strong adverse impact on graft survival. The results indicate that a posttransplant HLAab monitoring routine could be appropriate to improve long-term results.
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Levey, A. S., Bosch, J. P., Lewis, J. B., Greene, T., Rogers, N., Roth, D., & for the Modification of Diet in Renal Disease Study Group* (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00002 · Cited by 15,079
Levey, A. S., Coresh, J., Greene, T., Stevens, L. A., Zhang, Y. (., Hendriksen, S., Kusek, J. W., & Van Lente, F. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-4-200608150-00004 · Cited by 5,725
Meier-Kriesche, H.-U., Schold, J. D., Srinivas, T. R., & Kaplan, B. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00332.x · Cited by 1,287
Solez, K., Colvin, R., Racusen, L., Sis, B., Halloran, P., Birk, P., Campbell, P., Cascalho, M., Collins, A., Demetris, A., et al. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01688.x · Cited by 1,082
Humoral Theory of Transplantation
Terasaki, P. I. (2003) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2003.00135.x · Cited by 609
Self-citationAntibody-Mediated Renal Allograft Rejection: Diagnosis and Pathogenesis
Colvin, R. B. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007010073 · Cited by 517
Predicting Kidney Graft Failure by HLA Antibodies: a Prospective Trial
Terasaki, P. I., & Ozawa, M. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00360.x · Cited by 453
Self-citationPei, R., Lee, J.-H., Shih, N.-J., Chen, M., & Terasaki, P. I. (2003) · Transplantation · doi:10.1097/00007890-200301150-00008 · Cited by 409
Self-citationFour-year Follow-up of a Prospective Trial of HLA and MICA Antibodies on Kidney Graft Survival
Terasaki, P., Ozawa, M., & Castro, R. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01644.x · Cited by 362
Self-citationMao, Q., Terasaki, P., Cai, J., Briley, K., Catrou, P., Haisch, C., & Rebellato, L. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01711.x · Cited by 221
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Cited by
Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Loupy, A., Lefaucheur, C., Vernerey, D., Prugger, C., van Huyen, J.-P. D., Mooney, N., Suberbielle, C., Frémeaux-Bacchi, V., Méjean, A., Desgrandchamps, F., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302506 · Cited by 852
Tait, B. D., Süsal, C., Gebel, H. M., Nickerson, P. W., Zachary, A. A., Claas, F. H. J., Reed, E. F., Bray, R. A., Campbell, P., Chapman, J. R., et al. (2013) · Transplantation · doi:10.1097/tp.0b013e31827a19cc · Cited by 787
Self-citationBaker, R. J., Mark, P. B., Patel, R. K., Stevens, K. K., & Palmer, N. (2017) · BMC Nephrology · doi:10.1186/s12882-017-0553-2 · Cited by 211
Metadata
- Authors
- Lachmann, N., Terasaki, P. I., Budde, K., Liefeldt, L., Kahl, A., Reinke, P., Pratschke, J., Rudolph, B., Schmidt, D., Salama, A., & Schönemann, C.
- Venue
- Transplantation
- Published
- 2009-05-27
- Volume
- 87
- Issue
- 10
- Pages
- 1505-1513
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2067863998
- Cited by
- 344
- References
- 20
- FWCI
- 16.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Anti-Human Leukocyte Antigen and Donor-Specific Antibodies Detected by Luminex Posttransplant Serve as Biomarkers for Chronic Rejection of Renal Allografts. https://app.cochat.ai/papers/10.1097/tp.0b013e3181a44206
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- Lachmann, N., Terasaki, P. I., Budde, K., Liefeldt, L., Kahl, A., Reinke, P., Pratschke, J., Rudolph, B., Schmidt, D., Salama, A., & Schönemann, C. (2009). Anti-Human Leukocyte Antigen and Donor-Specific Antibodies Detected by Luminex Posttransplant Serve as Biomarkers for Chronic Rejection of Renal Allografts. Transplantation. https://doi.org/10.1097/tp.0b013e3181a44206
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