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The Psychometric Properties and Practicability of Self-Report Instruments to Identify Medication Nonadherence in Adult Transplant Patients: A Systematic Review
Abstract
INTRODUCTION: Nonadherence to immunosuppressive therapy is recognized as a key prognostic indicator for poor posttransplantation long-term outcomes. Several methods aiming to measure medication nonadherence have been suggested in the literature. Although combining measurement methods is regarded as the gold standard for measuring nonadherence, self-report is generally considered a central component of adherence assessment. However, no systematic review currently exists to determine which instrument(s) are most appropriate for use in transplant populations. METHODOLOGY: The transplant360 Task Force first performed a survey of the self-report adherence instruments currently used in European centers. Next, a systematic literature review of self-report instruments assessing medication adherence in chronically ill patients was conducted. Self-report instruments were evaluated to assess those which were: (a) short and easy to score; (b) assessed both the taking and timing of medication intake; and (c) had established reliability and validity. RESULTS: Fourteen instruments were identified from our survey of European centers, of which the Basel Assessment of Adherence Scale for Immunosuppressives met the aforementioned criteria. The systematic review found 20 self-report instruments, of which only two qualified for use in transplantation, that is, the Brief Antiretroviral Adherence Index and the Medication Adherence Self-Report Inventory. DISCUSSION: The three selected self-report scales may assist transplant professionals in detecting nonadherence. However, these scales were only validated in patients with HIV. Although HIV shares similar characteristics with transplantation, including the importance of taking and timing of medication, further validation in transplant populations is required.
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“Adherence can further be assessed by patients’ self-reports, e.g. the validated questionnaire BAASIS©[26].”
From Adherence is associated with a favorable outcome after lung transplantation (2019) · cites this paper as [26]
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Metadata
- Authors
- Dobbels, F., Berben, L., De Geest, S., Drent, G., Lennerling, A., Whittaker, C., & Kugler, C.
- Affiliations
- KU Leuven (BE)
- University of Basel (CH)
- University Medical Center Groningen (NL)
- Sahlgrenska University Hospital (SE)
- Royal London Hospital (GB)
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Dobbels, Fabienne
- Venue
- Transplantation
- Published
- 2010-07-27
- Volume
- 90
- Issue
- 2
- Pages
- 205-219
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2116897123
- Cited by
- 220
- References
- 54
- Citations by year
- 2025: 11 · 2024: 6 · 2023: 20 · 2022: 27 · 2021: 21 · 2020: 19 · 2019: 21 · 2018: 14 · 2017: 15 · 2016: 12 · 2015: 12 · 2014: 10 · 2013: 14 · 2012: 9
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Health Professions › Pharmacy › Pharmacy and Medical Practices
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- medication non-adherence, transplant recipients, immunosuppressive therapy, psychometric properties, adherence measurement, instrument validation
- MeSH terms
- Assessment of Medication Adherence, Adult, Humans, Immunosuppression Therapy, Prognosis, Psychometrics, Surveys and Questionnaires, Transplantation, Reproducibility of Results, Treatment Outcome, Drug Monitoring, Risk Assessment, Patient Selection, Medication Adherence
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