The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The immune system's role in the biology of autism
Open accessAbstract
PURPOSE OF REVIEW: The following is a review of the most recent research concerning the potential role of immune system dysfunction in autism. This body of literature has expanded dramatically over the past few years as researchers continue to identify immune anomalies in individuals with autism. RECENT FINDINGS: The most exciting of these recent findings is the discovery of autoantibodies targeting brain proteins in both children with autism and their mothers. In particular, circulating maternal autoantibodies directed toward fetal brain proteins are highly specific for autism. This finding has great potential as a biomarker for disease risk and may provide an avenue for future therapeutics and prevention. Additionally, data concerning the cellular immune system in children with autism suggest there may be a defect in signaling pathways that are shared by the immune and central nervous systems. Although studies to explore this hypothesis are ongoing, there is great interest in the commonalities between the neural and immune systems and their extensive interactions. SUMMARY: In summary, the exciting research regarding the role of the immune system in autism spectrum disorders may have profound implications for diagnosis and treatment of this devastating disease.
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Cites
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“Transforming Growth Factor Beta (TGF-β) has been linked to ASD in multiple studies [10– 12].”
BackgroundResultInfluentialThe immune response in autism: a new frontier for autism research
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Elevated cytokine levels in children with autism spectrum disorder
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Maternal antibrain antibodies in autism
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Cited by
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
Masi, A., DeMayo, M. M., Glozier, N., & Guastella, A. J. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0100-y · Cited by 987
Eyles, D. W., Burne, T. H. J., & McGrath, J. J. (2013) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.07.001 · Cited by 699
The immune system and developmental programming of brain and behavior
Bilbo, S. D., & Schwarz, J. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.006 · Cited by 580
Elevated fetal steroidogenic activity in autism
Baron-Cohen, S., Auyeung, B., Nørgaard-Pedersen, B., Hougaard, D. M., Abdallah, M. W., Melgaard, L., Cohen, A. S., Chakrabarti, B., Ruta, L., & Lombardo, M. V. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.48 · Cited by 471
Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis
Masi, A., Quintana, D. S., Glozier, N., Lloyd, A. R., Hickie, I. B., & Guastella, A. J. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.59 · Cited by 466
Metadata
- Authors
- Goines, P., & Van de Water, J.
- Venue
- Current Opinion in Neurology
- Published
- 2010-04
- Volume
- 23
- Issue
- 2
- Pages
- 111-117
- ISSN
- 1350-7540 (ISSN-L)
- OpenAlex
- W2028169172
- Cited by
- 245
- References
- 17
- FWCI
- 15.75
- Type
- journal article
- Language
- en
- Open access
- green
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