The DOI matches its Crossref record, with a small difference in title or year; 26 of the 26 references it cites were found in a registry or an index.
Minocycline as Adjunctive Therapy for Schizophrenia: An Open-Label Study
Abstract
Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase, and has been shown to delay disease in a mouse model of neuropsychiatric disorders. Recently, we reported the antipsychotic effects of minocycline in patients with schizophrenia. In a pilot investigation, we administered minocycline (150 mg/d) for 4 weeks as an open-label adjunct to antipsychotic medication to 22 patients with schizophrenia. The Positive and Negative Syndrome Scale for schizophrenia showed statistically significant and robust clinical improvements with minocycline treatment, which were maintained at follow-up evaluation 4 weeks after the end of minocycline treatment. There were no adverse events. These results suggest that minocycline may be a safe and effective adjunct to antipsychotic medications, and that augmentation with minocycline may prove to be a viable strategy for "boosting" antipsychotic efficacy and for treating schizophrenia.
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“Various clinical trials have been conducted using minocycline alone or as an adjunct to risperidone in patients with schizophrenia and have demonstrated overall improvement in negative symptoms and executive functioning (Miyaoka et al., 2008; Levkovitz et al., 2010; Khodaie-Ardakani et al., 2014).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Miyaoka et al., 2008
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Metadata
- Authors
- Miyaoka, T., Yasukawa, R., Yasuda, H., Hayashida, M., Inagaki, T., & Horiguchi, J.
- Affiliations
- Shimane University (JP)
- Corresponding author
- Miyaoka, Tsuyoshi
- Venue
- Clinical Neuropharmacology
- Published
- 2008-09
- Volume
- 31
- Issue
- 5
- Pages
- 287-292
- ISSN
- 0362-5664 (ISSN-L)
- OpenAlex
- W2018922612
- Cited by
- 146
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 14 · 2017: 7 · 2016: 9 · 2015: 14 · 2014: 15 · 2013: 14 · 2012: 13
- FWCI
- 6.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- minocycline, schizophrenia, adjunctive therapy, antipsychotic augmentation, caspase inhibition, inducible nitric oxide synthase, antipsychotic efficacy
- MeSH terms
- Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Minocycline, Pilot Projects, Schizophrenia, Schizophrenic Psychology, Young Adult
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