Cited by 116Multiple Sclerosis Research StudiesPharmacovigilance and Adverse Drug ReactionsTryptophan and brain disorders

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Severe Depression, Suicide Attempts, and Ideation During the Use of Interferon Beta by Patients With Multiple Sclerosis

Fragoso, Yara Dadalti, Frota, Elizabeth Regina Comini, Lopes, Juarez Silva, Noal, Janaina Silveira, Giacomo, Maria Cristina, Gomes, Sidney, Gonçalves, Marcus Vinicius Magno, da Gama, Paulo Diniz, Finkelsztejn, Alessandro·2010·Clinical Neuropharmacology

DOI 10.1097/wnf.0b013e3181f8d513

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Abstract

BACKGROUND: Interferon (IFN) beta is a safe and efficient drug for treating multiple sclerosis (MS). It is widely accepted that previously depressed patients may get worse when using IFN-beta. There are few reports on the association of IFN-beta and severe depression among patients without previous psychiatric history. METHODS: Discussion of a case of a patient with MS who developed severe depression and attempted suicide while using IFN-beta encouraged us to review the subject. A group of neurologists in Brazil retrospectively gathered together their similar cases for the present paper. RESULTS: The present paper reports on 11 cases of severe depression with suicide attempts or ideation among patients with MS who were using IFN-beta. These patients had no previous history of any psychiatric disease. Nine patients developed the symptoms over a relatively short period (4 months, on average). Two patients developed severe depression after more than 1 year of treatment with IFN-beta. Phobic, aggressive, behavioral, psychotic, and manic symptoms also were observed in these patients, thus suggesting the existence of a complex mood-behavior disorder associated with this drug. Interferon beta withdrawal led to complete remission of symptoms. The Naranjo algorithm established a highly probable association between IFN-beta and this adverse reaction in these patients. CONCLUSIONS: Although uncommon, severe depression with suicide ideation or attempts may be observed during treatment of MS with IFN-beta. This association should not discourage the use of this drug, but physicians need to be aware of this possible adverse event from IFN-beta.

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Authors: Fragoso, Y. D., Frota, E. R. C., Lopes, J. S., Noal, J. S., Giacomo, M. C., Gomes, S., Gonçalves, M. V. M., da Gama, P. D., & Finkelsztejn, A.
Affiliations: Beneficência Portuguesa de São Paulo (BR)
Hospital de Clínicas de Porto Alegre (BR)
Corresponding author: Finkelsztejn, Alessandro
ORCID: Gomes, Sidney
Finkelsztejn, Alessandro
Venue: Clinical Neuropharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-11
Volume: 33
Issue: 6
Pages: 312-316
ISSN: 0362-5664 (ISSN-L)
DOI: 10.1097/wnf.0b013e3181f8d513
OpenAlex: W2018025671
Cited by: 116
References: 24
Citations by year: 2026: 1 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 3 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 18 · 2017: 4 · 2016: 10 · 2015: 12 · 2014: 9 · 2013: 7 · 2012: 9
FWCI: 4.98
Type: journal article
Language: en
Open access: closed
Locations: Clinical Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: interferon-beta, multiple sclerosis, severe depression, suicide attempts, suicidal ideation, adverse drug reactions, interferon withdrawal, Naranjo algorithm, psychiatric adverse effects
MeSH terms: Adult, Brazil, Depressive Disorder, Female, Humans, Interferon Type I, Male, Middle Aged, Multiple Sclerosis, Recombinant Proteins, Suicide, Attempted, Prevalence, Treatment Outcome, Drug Monitoring, Mood Disorders, Young Adult, Suicidal Ideation

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Severe Depression, Suicide Attempts, and Ideation During the Use of Interferon Beta by Patients With Multiple Sclerosis

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