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Structure and Function of the Human Insula
Open accessAbstract
Summary: The insular cortex, or “Island of Reil,” is hidden deep within the lateral sulcus of the brain. Subdivisions within the insula have been identified on the basis of cytoarchitectonics, sulcal landmarks, and connectivity. Depending on the parcellation technique used, the insula can be divided into anywhere between 2 and 13 distinct subdivisions. The insula subserves a wide variety of functions in humans ranging from sensory and affective processing to high-level cognition. Here, we provide a concise summary of known structural and functional features of the human insular cortex with a focus on lesion case studies and recent neuroimaging evidence for considerable functional heterogeneity of this brain region.
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“The insula can be considered as a hub integrating exteroceptive sensory inputs and interoceptive signals (Uddin, Nomi, H ebert-Seropian, Ghaziri, & Boucher, 2017), and linking external and internal experiences.”
From The Peripersonal Space in a social world (2021) · cites this paper as Uddin et al., 2017
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“many anatomical features of the insula are shared across rodents and humans, suggesting its role in some fundamental and evolutionarily conserved functions [10].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [10]
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“Although the human insula has a uniquely larger number of gyri and increased volume relative to brain size, many anatomical features of the insula are shared across rodents and humans, suggesting its role in some fundamental and evolutionarily conserved functions [10].”
From The Insular Cortex: An Interface Between Sensation, Emotion and Cognition (2024) · cites this paper as [10]
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Metadata
- Authors
- Uddin, L. Q., Nomi, J. S., Hébert-Seropian, B., Ghaziri, J., & Boucher, O.
- Affiliations
- University of Miami (US)
- Université de Montréal (CA)
- Université du Québec à Montréal (CA)
- Corresponding author
- Uddin, Lucina Q.
- Nomi, Jason S.
- Venue
- Journal of Clinical Neurophysiology
- Published
- 2017-07
- Volume
- 34
- Issue
- 4
- Pages
- 300-306
- ISSN
- 0736-0258 (ISSN-L)
- PMC
- PMC6032992
- OpenAlex
- W2732740969
- Cited by
- 1,262
- References
- 85
- Citations by year
- 2026: 113 · 2025: 212 · 2024: 226 · 2023: 193 · 2022: 178 · 2021: 175 · 2020: 98 · 2019: 51 · 2018: 11 · 2017: 2
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (R01MH107549)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
- Keywords
- insula, Sylvian fissure, cytoarchitecture, functional heterogeneity, sensory processing, emotional processing, cognition, neuroimaging
- MeSH terms
- Cerebral Cortex, Humans
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