Citalopram modulation of neuronal responses to aversive face emotions: a functional MRI study
Abstract
This study investigated the serotonergic modulation of face emotion processing using blood oxygen level-dependent (BOLD) functional MRI. In a placebo-controlled, balanced order design, intravenous citalopram (7.5 mg) was given to 12 male volunteers 60 min before a covert face emotion recognition task. Angry, disgusted and fearful faces produced BOLD signal responses, which were broadly consistent with previous findings. Citalopram enhanced the BOLD signal response in the left posterior insula (together with nonprespecified pulvinar and visual cortex) but attenuated activation in the left amygdala to disgusted faces and right amygdala activation to fearful faces. No citalopram modulation of BOLD responses to angry faces were found. These results suggest that serotonin modulates low-level amygdala activation to aversive stimuli.
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Studies acutely enhancing 5-HT with citalopram found decreased amygdala responses to negative compared with neutral faces.
“Studies acutely enhancing 5-HT function with citalopram have found decreased amygdala responses to negative compared with neutral faces (Anderson et al., 2007;Del-Ben et al., 2005;Murphy et al., 2009a) but increased activation comparing faces (emotional and neutral) and a sensorimotor control task (Bigos et al., 2008).”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Anderson et al., 2007
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- Authors
- Anderson, I. M., Del-Ben, C. M., Mckie, S., Richardson, P., Williams, S. R., Elliott, R., & William Deakin, J. F.
- Affiliations
- University of Manchester (GB)
- Sheffield Hallam University (GB)
- Corresponding author
- Anderson, Ian M.
- Venue
- NeuroReport
- Published
- 2007-08-27
- Volume
- 18
- Issue
- 13
- Pages
- 1351-1355
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W1984163458
- Cited by
- 129
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 4 · 2015: 14 · 2014: 6 · 2013: 9 · 2012: 8
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- citalopram, serotonin, aversive emotions, amygdala, posterior insula, disgust, fear, anger, facial emotion recognition, serotonergic modulation
- MeSH terms
- Adult, Brain, Brain Mapping, Emotions, Face, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Citalopram, Single-Blind Method, Antidepressive Agents, Second-Generation
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