Cited by 740Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

Dissociable Neural Responses in Human Reward Systems

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Elliott, Rebecca, Friston, Karl J., Dolan, Raymond J.·2000·The Journal of Neuroscience

Abstract

Reward is one of the most important influences shaping behavior. Single-unit recording and lesion studies in experimental animals have implicated a number of regions in response to reinforcing stimuli, in particular regions of the extended limbic system and the ventral striatum. In this experiment, functional neuroimaging was used to assess neural response within human reward systems under different psychological contexts. Nine healthy volunteers were scanned using functional magnetic resonance imaging during the performance of a gambling task with financial rewards and penalties. We demonstrated neural sensitivity of midbrain and ventral striatal regions to financial rewards and hippocampal sensitivity to financial penalties. Furthermore, we show that neural responses in globus pallidus, thalamus, and subgenual cingulate were specific to high reward levels occurring in the context of increasing reward. Responses to both reward level in the context of increasing reward and penalty level in the context of increasing penalty were seen in caudate, insula, and ventral prefrontal cortex. These results demonstrate dissociable neural responses to rewards and penalties that are dependent on the psychological context in which they are experienced.

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Crossref · 10.1523/jneurosci.20-16-06159.2000

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  • The ventral striatum has been implicated in reward-related processing in humans and animals.

    “The ventral striatum has been implicated in reward-related processing in humans (Knutson, Adams, Fong, & Hommer, 2001; McClure, York, & Montague, 2004) and animals (Elliott, Friston, & Dolan, 2000).”

    From Gender Differences in Emotion Regulation: An fMRI Study of Cognitive Reappraisal (2008) · cites this paper as Elliott, Friston, & Dolan, 2000

    The Discussion says animal studies identify the ventral striatum as important in reward-related processing. But Elliott et al.’s own experiment used functional imaging in human volunteers, so the citation supports the animal finding as reported background, not as an animal study conducted by Elliott et al. (LLM, conf=0.88)

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Cites

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1 of the 55 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Everitt BJ, Robbins TW (1992) Amygdala-ventral striatum interactions and reward-related processes. In: The amygdala (Aggleton JP, ed). New York: Wiley.
  2. Gray JA (1982) The neuropsychology of anxiety: an enquiry into func- tions of the septo-hippocampal system. Oxford: Oxford UP.
  3. Talairach J, Tournoux P (1988) Coplanar stereotactic atlas of the human brain. Stuttgart: George Thieme Verlag.

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Authors
Elliott, R., Friston, K. J., & Dolan, R. J.
Affiliations
  • UCL Queen Square Institute of Neurology (GB)
  • The Royal Free Hospital (GB)
Venue
The Journal of Neuroscience
Published
2000-08-15
Volume
20
Issue
16
Pages
6159-6165
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2105389170
Cited by
740
References
55
Citations by year
2026: 2 · 2025: 9 · 2024: 23 · 2023: 16 · 2022: 10 · 2021: 13 · 2020: 18 · 2019: 12 · 2018: 20 · 2017: 21 · 2016: 15 · 2015: 34 · 2014: 36 · 2013: 29 · 2012: 50
FWCI
13.62
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords
reward processing, punishment, monetary rewards, fines, gambling task, ventral striatum, midbrain, hippocampus, globus pallidus, thalamus, subgenual anterior cingulate cortex, caudate nucleus, insula, ventral prefrontal cortex
MeSH terms
Brain, Brain Mapping, Emotions, Humans, Magnetic Resonance Imaging, Motivation, Neuropsychological Tests, Psychomotor Performance, Reward

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