Increased response variability in autistic brains?
Abstract
One of the key ideas regarding atypical connectivity in autistic brains is the hypothesis of noisier networks. The systems level version of this hypothesis predicts reduced reliability or increased variability in the evoked responses of individuals with autism. Using magnetoencephalography, we examined the response of individuals with autism spectrum disorder versus matched typically developing persons to passive tactile stimulation of the thumb and index finger of the dominant (right) hand. A number of different analyses failed to show higher variability in the evoked response to the thumb or to the index finger in the autism group as compared with typicals. Our results argue against the hypothesis that the brain networks in autism are noisier than normal.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent work suggests autism spectrum disorder differences may be associated with reliability of behavioral performance and evoked neural responses, not only activation differences.
“more recent work has also investigated the possibility that differences in ASD may not be necessarily found in only differences in activation, but also may be associated with differences in the reliability of behavioral performance (Geurts et al., 2008) or evoked neural responses (Coskun et al., 2009; Dinstein et al., 2012; Haigh et al., 2014; Milne, 2011).”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Coskun et al., 2009
Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486 · see citing works
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb00917.x · Cited by 49,574 · see citing works
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900 · see citing works
The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
ON THE MATHEMATICAL THEORY OF COMMUNICATION
Takada, Y. (1954) · The Japanese journal of psychology · doi:10.4992/jjpsy.25.110 · Cited by 1,662 · see citing works
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589 · see citing works
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487 · see citing works
Castelli, F. (2002) · Brain · doi:10.1093/brain/awf189 · Cited by 1,377 · see citing works
Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl006 · Cited by 1,081 · see citing works
Nonlinear multivariate analysis of neurophysiological signals
Pereda, E., Quiroga, R. Q., & Bhattacharya, J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.10.003 · Cited by 1,066 · see citing works
The probability of transmitter release at a mammalian central synapse
Hessler, N. A., Shirke, A. M., & Malinow, R. (1993) · Nature · doi:10.1038/366569a0 · Cited by 617 · see citing works
Nonuniform probability of glutamate release at a hippocampal synapse.
Rosenmund, C., Clements, J., & Westbrook, G. (1993) · Science · doi:10.1126/science.7901909 · Cited by 616 · see citing works
Functional connectivity in an fMRI working memory task in high-functioning autism
Koshino, H., Carpenter, P. A., Minshew, N. J., Cherkassky, V. L., Keller, T. A., & Just, M. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.09.028 · Cited by 614 · see citing works
Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys
Herbert, M. R., Ziegler, D. A., Deutsch, C., O’Brien, L. M., LANGE, N. D., Bakardjiev, A. I., Hodgson, J. M., Adrien, K. T., Steele, S., Makris, N., et al. (2003) · Brain · doi:10.1093/brain/awg110 · Cited by 494 · see citing works
The developmental neurobiology of autism spectrum disorder
DiCicco-Bloom, E., Lord, C., Zwaigenbaum, L., Courchesne, E., Dager, S. R., Schmitz, C., Schultz, R. T., Crawley, J., & Young, L. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1712-06.2006 · Cited by 434 · see citing works
Brain asymmetries in autism and developmental language disorder: a nested whole-brain analysis
Herbert, M. R. (2004) · Brain · doi:10.1093/brain/awh330 · Cited by 421 · see citing works
Villalobos, M. E., Mizuno, A., Dahl, B. C., Kemmotsu, N., & Müller, R.-A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.022 · Cited by 312 · see citing works
Hussman, J. P. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010715619091 · Cited by 263 · see citing works
Sayer, R., Friedlander, M. J., & Redman, S. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-03-00826.1990 · Cited by 238 · see citing works
Toward a developmental neurobiology of autism
Polleux, F., & Lauder, J. M. (2004) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20044 · Cited by 216 · see citing works
Functional neuroimaging of speech perception during a pivotal period in language acquisition
Redcay, E., Haist, F., & Courchesne, E. (2008) · Developmental Science · doi:10.1111/j.1467-7687.2008.00674.x · Cited by 102 · see citing works
Bachevalier, J., Málková, L., & Mishkin, M. (2001) · Behavioral Neuroscience · doi:10.1037//0735-7044.115.3.545 · Cited by 73 · see citing works
Bachevalier, J., Málková, L., & Mishkin, M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.3.545 · Cited by 73 · see citing works
Estimating Scalp MEG from Whole-Head MEG Measurements
Wang, Y., & Oertel, U. (2000) · Brain Topography · doi:10.1023/a:1023493908085 · Cited by 6 · see citing works
Flagged first, then by citations
4 of the 29 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Motor coordination in autism spectrum disorders: A synthesis and meta-analysis
Fournier, K. A., Hass, C. J., Naik, S. K., Lodha, N., & Cauraugh, J. H. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-0981-3 · Cited by 1,271 · see citing works
Baum, S. H., Stevenson, R. A., & Wallace, M. T. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.007 · Cited by 370 · see citing works
Karalunas, S. L., Geurts, H. M., Konrad, K., Bender, S., & Nigg, J. T. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12217 · Cited by 278 · see citing works
Inter-Regional Brain Communication and Its Disturbance in Autism
Schipul, S. E., Keller, T. A., & Just, M. A. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00010 · Cited by 223 · see citing works
Balasco, L., Provenzano, G., & Bozzi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01016 · Cited by 183 · see citing works
Autism spectrum disorder in the scope of tactile processing
Mikkelsen, M. E., Wodka, E. L., Mostofsky, S. H., & Puts, N. A. J. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.12.005 · Cited by 162 · see citing works
Cortical variability in the sensory-evoked response in autism
Haigh, S. M., Heeger, D. J., Dinstein, I., Minshew, N., & Behrmann, M. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2276-6 · Cited by 113 · see citing works
Individuals with autism spectrum disorder have altered visual encoding capacity
Noel, J., Zhang, L.-Q., Stocker, A. A., & Angelaki, D. E. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001215 · Cited by 116 · see citing works
Children with autism spectrum disorder have unstable neural responses to sound
Otto‐Meyer, S., Krizman, J., White‐Schwoch, T., & Kraus, N. (2018) · Experimental Brain Research · doi:10.1007/s00221-017-5164-4 · Cited by 88 · see citing works
Multisensory speech perception in autism spectrum disorder: From phoneme to whole‐word perception
Stevenson, R. A., Baum, S. H., Segers, M., Ferber, S., Barense, M. D., & Wallace, M. T. (2017) · Autism Research · doi:10.1002/aur.1776 · Cited by 82 · see citing works
Park, W. J., Schauder, K. B., Zhang, R., Bennetto, L., & Tadin, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-17676-5 · Cited by 74 · see citing works
Variability of cortical oscillation patterns: A possible endophenotype in autism spectrum disorders?
David, N., Schneider, T. R., Peiker, I., Al‐Jawahiri, R., Engel, A. K., & Milne, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.031 · Cited by 63 · see citing works
Variable sensory perception in autism
Haigh, S. M. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13601 · Cited by 61 · see citing works
Functional Data Analysis in brain imaging studies
Tian, T. (2010) · Frontiers in Psychology · doi:10.3389/fpsyg.2010.00035 · Cited by 41 · see citing works
Over‐Responsiveness and Greater Variability in Roughness Perception in Autism
Haigh, S. M., Minshew, N. J., Heeger, D. J., Dinstein, I., & Behrmann, M. (2015) · Autism Research · doi:10.1002/aur.1505 · Cited by 34 · see citing works
Beker, S., Foxe, J. J., Venticinque, J., Bates, J. C., Ridgeway, E. M., Schaaf, R. C., & Molholm, S. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-021-09383-0 · Cited by 26 · see citing works
Functional Assays of Local Connectivity in the Somatosensory Cortex of Individuals with Autism
Coskun, M. A., Loveland, K. A., Pearson, D. A., Papanicolaou, A. C., & Sheth, B. R. (2013) · Autism Research · doi:10.1002/aur.1276 · Cited by 24 · see citing works
Magnetoencephalography in neuropsychiatry: ready for application?
Williams, M., & Sachdev, P. S. (2010) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328338621d · Cited by 18 · see citing works
Visual working memory and sensory processing in autistic children
Stevenson, R. A., Ruppel, J., Sun, S. Z., Segers, M., Zapparoli, B. L., Bebko, J. M., Barense, M. D., & Ferber, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-82777-1 · Cited by 14 · see citing works
Atypical neural variability in carriers of 16p11.2 copy number variants
Al‐Jawahiri, R., Jones, M., & Milne, E. (2019) · Autism Research · doi:10.1002/aur.2166 · Cited by 12 · see citing works
Does stochastic resonance improve performance for individuals with higher autism-spectrum quotient?
Raul, P., McNally, K., Ward, L. M., & van Boxtel, J. J. A. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1110714 · Cited by 12 · see citing works
Visual Noise Effect on Contour Integration and Gaze Allocation in Autism Spectrum Disorder
Mihaylova, M., Bocheva, N. B., Totev, T., & Staykova, S. N. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.623663 · Cited by 9 · see citing works
Orchard, E. R., Dakin, S. C., & van Boxtel, J. J. A. (2022) · Journal of Vision · doi:10.1167/jov.22.10.19 · Cited by 8 · see citing works
Trial‐to‐Trial Variability in Electrodermal Activity to Odor in Autism
Haigh, S. M., Endevelt–Shapira, Y., & Behrmann, M. (2020) · Autism Research · doi:10.1002/aur.2377 · Cited by 7 · see citing works
Ash, R. T., Palagina, G., Fernández-León, J. A., Park, J., Seilheimer, R. L., Lee, S., Sabharwal, J., Reyes, F., Wang, J., Lu, D., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0654-22.2022 · Cited by 5 · see citing works
Beker, S., Foxe, J. J., Venticinque, J., Bates, J. C., Ridgeway, E. M., Schaaf, R. C., & Molholm, S. (2021) · Research Square · doi:10.21203/rs.3.rs-240084/v1 · Cited by 2 · see citing works
Psychological Theories of Autism: Everything, All at Once, In One PlacePreprint
Ewen, J. B. (2023) · doi:10.31234/osf.io/kguq2 · Cited by 2 · see citing works
Moppert, S., & Mercado, E. (2024) · Developmental Psychobiology · doi:10.1002/dev.22504 · Cited by 1 · see citing works
Neural Activity of 16p11.2 CNV Human and Mouse
Al‐Jawahiri, R. (2019) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Burner, K., & Bernier, R. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1698-3_646
Cornew, L., & Roberts, T. P. L. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_736
Burner, K., & Bernier, R. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_646
Beker, S., Foxe, J. J., Venticinque, J., Bates, J. C., Ridgeway, E. M., Schaaf, R. C., & Molholm, S. (2021) · Figshare · doi:10.6084/m9.figshare.16714073
Beker, S., Foxe, J. J., Venticinque, J., Bates, J. C., Ridgeway, E. M., Schaaf, R. C., & Molholm, S. (2021) · Figshare · doi:10.6084/m9.figshare.16714070
- Authors
- Coskun, M. A., Varghese, L., Reddoch, S., Castillo, E. M., Pearson, D. A., Loveland, K. A., Papanicolaou, A. C., & Sheth, B. R.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- University of Houston (US)
- Corresponding author
- Sheth, Bhavin R.
- Venue
- Neuroreport
- Published
- 2009-11-25
- Volume
- 20
- Issue
- 17
- Pages
- 1543-1548
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2099265506
- Cited by
- 34
- References
- 29
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 9 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Autism Speaks (AS1362)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- autism spectrum disorder, response variability, evoked potentials, neural reliability, somatosensory evoked potentials
- MeSH terms
- Adolescent, Autistic Disorder, Brain, Evoked Potentials, Humans, Nerve Net, Neuropsychological Tests, Perception, Physical Stimulation, Predictive Value of Tests, Sensitivity and Specificity, Magnetoencephalography, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
