Site-specific subtypes of macrophages recruited after peripheral nerve injury
Abstract
After partial ligation of mouse sciatic nerve, the subtypes of macrophages were examined in the injured nerve and dorsal root ganglia (DRGs). Many M1 macrophages, which were inducible nitric oxide synthase (iNOS)-positive and arginase-1 (Arg-1)-negative, and neutrophils infiltrated the injured nerve. In contrast, almost all macrophages infiltrating the ipsilateral side of DRGs after the nerve injury were iNOS⁻/Arg-1⁺, M2 type. The infiltration of M1 and M2 macrophages was first observed in the injured nerve and ipsilateral DRGs on days 1 and 2, respectively. In addition, the macrophage infiltration preceded the activation of microglia in the ipsilateral dorsal horn of spinal cord. Thus, infiltrating macrophages after peripheral nerve injury may play unique roles dependent on the location in the development of neuropathic pain.
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- Authors
- Komori, T., Morikawa, Y., Inada, T., Hisaoka, T., & Senba, E.
- Affiliations
- Wakayama Medical University (JP)
- Corresponding author
- Morikawa, Yoshihiro
- Venue
- Neuroreport
- Published
- 2011-12-07
- Volume
- 22
- Issue
- 17
- Pages
- 911-917
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2090477155
- Cited by
- 71
- References
- 22
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 5 · 2012: 4
- FWCI
- 3.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wakayama Medical University
- Japan Society for the Promotion of Science (21600011)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- macrophage polarization, M1 macrophages, M2 macrophages, peripheral nerve injury, sciatic nerve ligation, dorsal root ganglia, inducible nitric oxide synthase, arginase-1, neutrophils, microglial activation, neuropathic pain, macrophage infiltration
- MeSH terms
- Animals, Cell Count, Disease Models, Animal, Fluorescent Antibody Technique, Ganglia, Spinal, Macrophage Activation, Macrophages, Male, Mice, Inbred C57BL, Neuralgia, Sciatic Nerve, Spinal Cord, Antigens, CD, Microglia, Mice, Peripheral Nerve Injuries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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