Role of the Immune system in chronic pain
Abstract
During the past two decades, an important focus of pain research has been the study of chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity - spontaneous pain and hyperalgesia - that is associated with these states. For some time it has been recognized that inflammatory mediators released from immune cells can contribute to these persistent pain states. However, it has only recently become clear that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.
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Chronic pain is highly comorbid with depression.
“chronic pain has also been found to be highly comorbid with depression”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Marchand, Perretti, & McMahon, 2005
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- Authors
- Marchand, F., Perretti, M., & McMahon, S. B.
- Affiliations
- King's College London (GB)
- William Harvey Research Institute (GB)
- Venue
- Nature Reviews Neuroscience
- Published
- 2005-07
- Volume
- 6
- Issue
- 7
- Pages
- 521-532
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2092595668
- Cited by
- 1,098
- References
- 1
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 28 · 2023: 40 · 2022: 32 · 2021: 40 · 2020: 36 · 2019: 49 · 2018: 55 · 2017: 63 · 2016: 71 · 2015: 57 · 2014: 58 · 2013: 80 · 2012: 69
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- chronic pain, immune system, neuropathic pain, inflammatory pain, hyperalgesia, spontaneous pain, peripheral nerve injury, central nervous system injury, pain mechanisms
- MeSH terms
- Animals, Chronic Disease, Humans, Immune System, Models, Biological, Nociceptors, Pain, Annexin A1, Receptors, Formyl Peptide, Receptors, Lipoxin
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