Causes of premature mortality in schizophrenia: a review of literature published in 2018

Laursen, Thomas M.

doi:10.1097/yco.0000000000000530

Cited by 76Schizophrenia research and treatmentSuicide and Self-Harm StudiesMental Health and Psychiatry

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

Causes of premature mortality in schizophrenia: a review of literature published in 2018

Laursen, Thomas M.·2019·Current Opinion in Psychiatry

DOI 10.1097/yco.0000000000000530

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Abstract

PURPOSE OF REVIEW: The current review examines the recent literature on the causes of premature mortality in schizophrenia. RECENT FINDINGS: People with schizophrenia have higher premature mortality rates compared with the general population. Suicides and accidents account for a nontrivial part of the excess mortality, but the largest part is attributable to natural causes of death. Five major causes have been identified: first, adverse effects of medication; second, suboptimal lifestyle; third, somatic comorbidity; fourth, suboptimal treatment of somatic disorders; and fifth, accelerated ageing/genetic explanations. The positive aspect is that people with schizophrenia have increasing life expectancy, at least in high-income countries, and this development seems to largely follow the increase in the general population. Especially mortality rates from unnatural causes appear to have a positive impact. Nevertheless, despite more than 100 years of research and progress, the excess mortality in persons with schizophrenia remains unacceptably high, with no prospects of reaching the level in the general population. SUMMARY: The excess mortality in schizophrenia has received much focus. Future studies should explore the reasons for the high rates of natural causes of death, while aiming to disentangle the complex interplay between medication, lifestyle, comorbidity, treatment of somatic disorders, and genetic effects.

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Cardiometabolic risk factors such as cardiovascular disease and obesity are recognised major contributors to increased mortality in schizophrenia.
“While causes are multifactorial, cardiometabolic risk factors such as cardiovascular disease and obesity are recognised major contributors [1,2,10,11].”
From A systematic review of licensed weight-loss medications in treating antipsychotic-induced weight gain and obesity in schizophrenia and psychosis. (2022) · cites this paper as [11]

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Authors: Laursen, T. M.
Affiliations: Aarhus University (DK)
Corresponding author: Laursen, Thomas M.
ORCID: Laursen, Thomas M.
Venue: Current Opinion in Psychiatry
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2019-09
Volume: 32
Issue: 5
Pages: 388-393
ISSN: 0951-7367 (ISSN-L)
DOI: 10.1097/yco.0000000000000530
OpenAlex: W2946763672
Cited by: 76
References: 59
Citations by year: 2026: 6 · 2025: 6 · 2024: 11 · 2023: 14 · 2022: 17 · 2021: 13 · 2020: 7 · 2019: 2
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Locations: Current Opinion in Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: Lundbeckfonden (R248‐2017‐2003)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: schizophrenia, premature mortality, excess mortality, suicide, accidents, natural death, adverse drug reactions, lifestyle, somatic comorbidity, accelerated aging, genetic factors, life expectancy
MeSH terms: Humans, Life Expectancy, Life Style, Schizophrenia, Suicide, Antipsychotic Agents, Comorbidity, Mortality, Premature

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Causes of premature mortality in schizophrenia: a review of literature published in 2018

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