Life expectancy and cardiovascular mortality in persons with schizophrenia
Abstract
PURPOSE OF REVIEW: To assess the impact of cardiovascular disease on the excess mortality and shortened life expectancy in schizophrenic patients. RECENT FINDINGS: Patients with schizophrenia have two-fold to three-fold higher mortality rates compared with the general population, corresponding to a 10-25-year reduction in life expectancy. Although the mortality rate from suicide is high, natural causes of death account for a greater part of the reduction in life expectancy. The reviewed studies suggest four main reasons for the excess mortality and reduced life expectancy. First, persons with schizophrenia tend to have suboptimal lifestyles including unhealthy diets, excessive smoking and alcohol use, and lack of exercise. Second, antipsychotic drugs may have adverse effects. Third, physical illnesses in persons with schizophrenia are common, but diagnosed late and treated insufficiently. Lastly, the risk of suicide and accidents among schizophrenic patients is high. SUMMARY: Schizophrenia is associated with a substantially higher mortality and curtailed life expectancy partly caused by modifiable risk factors.
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Physical illnesses in persons with schizophrenia are common but are diagnosed late and treated insufficiently.
“Physical illnesses in persons with schizophrenia are common but are diagnosed late and treated insufficiently.”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2012
Antipsychotic medicine may have negative side effects.
“Antipsychotic medicine may have negative side effects.”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2012
Persons with schizophrenia tend to have an unhealthy lifestyle (poor diet, smoking, excess alcohol consumption, and lack of exercise).
“Persons with schizophrenia tend to have an unhealthy lifestyle (poor diet, smoking, excess alcohol consumption, and lack of exercise).”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2012
Persons with schizophrenia are more vulnerable to chronic physical diseases; risk of medical disease is higher and prognosis is poorer.
“Recently, it has been suggested that persons with schizophrenia are more vulnerable to chronic physical diseases; the risk of medical disease is higher, and the prognosis is poorer (Laursen et al. 2012).”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2012
The risk of suicide and accidents among patients with schizophrenia is high.
“The risk of suicide and accidents among patients with schizophrenia is high.”
From Excess early mortality in schizophrenia. (2014) · cites this paper as Laursen et al. 2012
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- Authors
- Laursen, T. M., Munk-Olsen, T., & Vestergaard, M.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Laursen, Thomas M.
- Venue
- Current Opinion in Psychiatry
- Published
- 2012-03
- Volume
- 25
- Issue
- 2
- Pages
- 83-88
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2327775854
- Cited by
- 518
- References
- 8
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 38 · 2023: 33 · 2022: 35 · 2021: 62 · 2020: 39 · 2019: 46 · 2018: 38 · 2017: 45 · 2016: 40 · 2015: 41 · 2014: 24 · 2013: 36 · 2012: 4
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, cardiovascular mortality, life expectancy, excess mortality, cardiovascular disease, suicide, antipsychotic adverse effects, lifestyle risk factors, smoking, alcohol consumption, physical illness, modifiable risk factors
- MeSH terms
- Cardiovascular Diseases, Humans, Life Expectancy, Life Style, Risk Factors, Schizophrenia, Suicide, Antipsychotic Agents
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