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Cited by 249Schizophrenia research and treatmentSuicide and Self-Harm StudiesMental Health and Psychiatry

Mortality in schizophrenia.

Auquier, Pascal, Lançon, Christophe, Rouillon, Frédéric, Lader, Malcolm, Holmes, Catriona·2006·Pharmacoepidemiology and Drug Safety
DOI 10.1002/pds.1325
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Abstract

PURPOSE: The purpose of this article is to describe the current status of knowledge on excess mortality in schizophrenia and its causative factors, and to expand upon previous work evaluating approaches that may reduce mortality rates. METHODS: Literature available since 1995 was identified in a computerized search of the bibliographical databases Medline and Embase, using the topics 'mortality' and 'schizophrenia', and in a cross-reference search for articles that were particularly relevant. RESULTS: Schizophrenia is associated with mortality rates that are two to three times higher than those expected or observed in the general population. This excess of mortality is accounted for by a combination of an increased risk of suicide, in particular in young male patients soon after diagnosis, and more importantly, a higher number of natural deaths. In order to diminish the level of suicide among people with schizophrenia, the majority of research has focused on the identification of risk factors that predispose patients to attempt or commit suicide, while unhealthy styles, polypharmacy and inadequate healthcare have been shown to contribute to the high natural mortality. The link between the use of antipychotics and mortality has not been yet clarified. CONCLUSION: Dramatically increased mortality of schizophrenia patients is well established. It is time to move beyond this topic, and work towards interventions that aim at reducing the mortality risk in such patients.

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Authors
Auquier, P., Lançon, C., Rouillon, F., Lader, M., & Holmes, C.
Affiliations
  • Hôpital de la Timone (FR)
  • Hôpital Sainte-Marguerite (FR)
  • Centre Hospitalier Sainte-Anne (FR)
Corresponding author
Auquier, Pascal
ORCID
Venue
Pharmacoepidemiology and Drug Safety
Publisher
Wiley
Published
2006-10-23
Volume
15
Issue
12
Pages
873-879
ISSN
  • 1053-8569 (ISSN-L)
  • 1099-1557
DOI
10.1002/pds.1325
OpenAlex
W2097031522
Cited by
249
References
77
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 11 · 2014: 13 · 2013: 20 · 2012: 27
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Pharmacoepidemiology and Drug Safety (publishedVersion)
  • PubMed (publishedVersion)
Funders
H. Lundbeck A/S
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, excess mortality, suicide risk, natural mortality, risk factors, polypharmacy, antipsychotic drugs, quality of care
MeSH terms
Cardiovascular Diseases, Cause of Death, Health Services Accessibility, Humans, Risk, Schizophrenia, Suicide, Antipsychotic Agents, Violence, Harm Reduction

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