Benzodiazepine Prescribing to the Swiss Adult Population: Results from a National Survey of Community Pharmacies
Abstract
UNLABELLED: The purpose of the study was to assess prevalence of benzodiazepine use in the Swiss adult population and to assess on benzodiazepine prescription patterns of physicians in domiciliary practice. STUDY DESIGN: A retrospective, population-based cross-sectional study with 520 000 patients covering a 6-month period. METHODS: We estimated the prevalence, amount and duration of benzodiazepine use using a pharmacy dispensing database. RESULTS: Of all patients, 9.1% (n=45 309) received at least one benzodiazepine prescription in the 6-month period. Most persons receiving benzodiazepine prescriptions were women (67%), and half of all patients were aged 65 or older. Of 45 309 patients with benzodiazepine prescriptions, 44% (n=19 954) had one single prescription, mostly for a short period (<90 days) and in lower than the recommended dose range. Fifty-six percent (n=25 354) had repeated benzodiazepine prescriptions, mostly for a long time period (>90 days), and in lower than the recommended or within the recommended dose range. In patients with long-term use (n=25 354), however, 1.6% had benzodiazepine prescriptions in extremely high doses. The sample of patients with repeated prescriptions allowed an estimation of a benzodiazepine use of 43.3 daily defined doses per 1000 inhabitants in Switzerland. CONCLUSIONS: Benzodiazepine prescriptions were appropriate for most patients and thus were prescribed in therapeutic doses, as indicated in the treatment guidelines. On the other hand, our survey showed that 1.6% of the patients had prescriptions for long time periods at very high doses, indicating an abuse or dependence on benzodiazepines in this subgroup.
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In a study of 520,000 Swiss patients, 14.5% had been using benzodiazepines beyond 12 months.
“A study of BZD use among 520,000 swiss patients shows that 14.5% of patients have been using BZD beyond 12 months, and like in France, this overuse tends to increase with age [16].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [16]
Benzodiazepine overuse tends to increase with age.
“A study of BZD use among 520,000 swiss patients shows that 14.5% of patients have been using BZD beyond 12 months, and like in France, this overuse tends to increase with age [16].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [16]
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- Authors
- Petitjean, S., Ladewig, D., Meier, C. R., Amrein, R., & Wiesbeck, G. A.
- Affiliations
- Universitäre Psychiatrische Kliniken Basel (CH)
- University Hospital of Basel (CH)
- Corresponding author
- Petitjean, Sylvie
- ORCID
- Meier, Christoph R.
- Venue
- International Clinical Psychopharmacology
- Published
- 2007-09
- Volume
- 22
- Issue
- 5
- Pages
- 292-298
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2053311281
- Cited by
- 132
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 7 · 2021: 11 · 2020: 22 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 10 · 2015: 11 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesamt für Gesundheit
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- benzodiazepines, benzodiazepine prescribing, prescribing patterns, benzodiazepine misuse, benzodiazepine dependence, long-term benzodiazepine use, community pharmacy dispensing
- MeSH terms
- Adolescent, Adult, Aged, Benzodiazepines, Cross-Sectional Studies, Dose-Response Relationship, Drug, Drug Utilization, Female, Health Surveys, Humans, Male, Middle Aged, Pharmacies, Drug Prescriptions, Retrospective Studies, Switzerland
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