Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques
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Over the last decade, 3D bioprinting has received immense attention from research communities to bridge the divergence between artificially engineered tissue constructs and native tissues.
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Incorporation of PLCL with natural polysaccharides such as hyaluronic acid and chitosan improves hydrophilicity and cartilage regeneration ability of scaffolds.
“the incorporation of PLCL with natural polysaccharides such as hyaluronic acid and chitosan can improve the hydrophilicity and cartilage regeneration ability of scaffolds [194]”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [194]
The Cartilage section (page unavailable) reports enhanced cartilage tissue formation in PCL–alginate scaffolds containing TGFβ. That offers partial support for a synthetic-polymer/polysaccharide scaffold improving cartilage formation, but the review does not report the claimed PLCL combination with hyaluronic acid or chitosan, or an improvement in hydrophilicity (searched: PLCL, hyaluronic acid, chitosan, hydrophilicity). (LLM, conf=0.78)
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- Authors
- Askari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M.
- Affiliations
- Amirkabir University of Technology (IR)
- Department of Engineering
- Isfahan University of Technology (IR)
- Materials and Energy Research Center (IR)
- Deakin University (AU)
- Nottingham Trent University (GB)
- Corresponding author
- Bodaghi, Mahdi
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2021
- Volume
- 9
- Issue
- 3
- Pages
- 535-573
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W3092161699
- Cited by
- 369
- References
- 349
- Citations by year
- 2026: 44 · 2025: 64 · 2024: 58 · 2023: 55 · 2022: 97 · 2021: 50 · 2020: 1
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biomaterials Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- Own your potential (DEAKIN) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Isfahan University of Medical Sciences
- Isfahan University of Technology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- hydrogel biomaterials, bioinks, tissue regeneration, tissue engineering scaffolds, skin scaffolds, bone scaffolds, cartilage scaffolds, vascular scaffolds, neural scaffolds, cardiac scaffolds, scaffold design
- MeSH terms
- Biocompatible Materials, Hydrogels, Tissue Engineering, Tissue Scaffolds, Bioprinting, Printing, Three-Dimensional
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