The ‘suprachiasmatic syndrome’: endocrine and behavioural abnormalities following lesions of the suprachiasmatic nuclei in the female rat
Abstract
Abstract Lesions of the suprachiasmatic nuclei that caused failure of spontaneous ovulation in female rats consistently produced abnormalities in other functions that are normally influenced by the light-dark cycle. In such animals morning plasma corticosterone concentrations were abnormally high and evening values abnormally low though the response to stress was unaffected. Pineal serotonin N-acetyl transferase activity was abnormally high in animals killed during the day and abnormally low in those killed at night. Although the animals were in persistent behavioural oestrus, total voluntary wheel-running activity was not consistently altered but was distributed evenly between the light and dark periods rather than being confined principally to the dark periods as in normal animals. Similarly the proportion of the daily water and food intake that occurred during the dark period was reduced. The incidence of these associated abnormalities was low in lesioned rats that continued to ovulate spontaneously.
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In traditional laboratory rodents, lesions of the SCN eliminate ovulation and produce a state of persistent estrus.
“In traditional laboratory rodents (rats, mice, hamsters), circadian regulation of the HPG axis has received particular attention because lesions of the SCN eliminate ovulation and produce a state of persistent estrus [39, 154].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [154]
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- Authors
- Raisman, G., & Brown-Grant, K.
- Affiliations
- University of Oxford (GB)
- Venue
- Proceedings of the Royal Society of London. Series B. Biological Sciences
- Publisher
- The Royal Society
- Published
- 1977-09-05
- Volume
- 198
- Issue
- 1132
- Pages
- 297-314
- ISSN
- 0080-4649 (ISSN-L)
- 2053-9193
- OpenAlex
- W2170577561
- Cited by
- 112
- References
- 36
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Proceedings of the Royal Society B Biological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- suprachiasmatic nucleus, circadian rhythm, spontaneous ovulation, corticosterone, wheel running, light-dark cycle, female rats, hypothalamic lesions
- MeSH terms
- Adrenal Cortex, Animals, Anovulation, Circadian Rhythm, Corticosterone, Drinking, Eating, Endocrine Glands, Female, Gonadotropins, Hypothalamus, Hypothalamus, Anterior, Male, Ovulation, Pineal Gland, Running, Sexual Behavior, Animal, Testis, Rats
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