The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Epidermal stem cells: markers, patterning and the control of stem cell fate
Open accessAbstract
Within the epidermis, proliferation takes place in the basal layer of keratinocytes that are attached to an underlying basement membrane. Cells that leave the basal layer undergo terminal differentiation as they move towards the tissue surface. The basal layer contains two types of proliferative keratinocyte: stem cells, which have unlimited self–renewal capacity, and transit amplifying cells, those daughters of stem cells that are destined to withdraw from the cell cycle and terminally differentiate after a few rounds of division. Stem cells express higher levels of the β 1–integrin family of extracellular matrix receptors than transit amplifying cells and this can be used to isolate each subpopulation of keratinocyte and to determine its location within the epidermis. Variation in the levels of E–cadherin, β–catenin and plakoglobin within the basal layer suggests that stem cells may also differ from transit amplifying cells in intercellular adhesiveness. Stem cells have a patterned distribution within the epidermal basal layer and patterning is subject to autoregulation. Constitutive expression of the transcription factor c–Myc promotes terminal differentiation by driving keratinocytes from the stem cell compartment into the transit amplifying compartment.
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276
Slowly cycling (label‐retaining) epidermal cells behave like clonogenic stem cells in vitro
Morris, R. J., & Potten, C. S. (1994) · Cell Proliferation · doi:10.1111/j.1365-2184.1994.tb01425.x · Cited by 207
Cited by
Dickson, M. A., Hahn, W. C., Ino, Y., Ronfard, V., Wu, J. Y., Weinberg, R. A., Louis, D. N., Li, F. P., & Rheinwald, J. G. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.4.1436-1447.2000 · Cited by 1,104
Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Taylor, G., Lehrer, M. S., Jensen, P. J., Sun, T.-T., & Lavker, R. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00050-7 · Cited by 1,070
Expression of Cd34 and Myf5 Defines the Majority of Quiescent Adult Skeletal Muscle Satellite Cells
Beauchamp, J. R., Heslop, L., Yu, D. S. W., Tajbakhsh, S., Kelly, R. G., Wernig, A., Buckingham, M. E., Partridge, T. A., & Zammit, P. S. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.6.1221 · Cited by 916
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Getting under the skin of epidermal morphogenesis
Fuchs, E., & Raghavan, S. (2002) · Nature Reviews Genetics · doi:10.1038/nrg758 · Cited by 753
Metadata
- Authors
- Watt, F. M.
- Venue
- Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 1998-06-29
- Volume
- 353
- Issue
- 1370
- Pages
- 831-837
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2149423925
- Cited by
- 400
- References
- 2
- FWCI
- 28.81
- Type
- journal article
- Language
- en
- Open access
- green
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