The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens
Open accessAbstract
Conventional antibiotics target the growth and the basal life processes of bacteria leading to growth arrest and cell death. The selective force that is inherently linked to this mode of action eventually selects out antibiotic-resistant variants. The most obvious alternative to antibiotic-mediated killing or growth inhibition would be to attenuate the bacteria with respect to pathogenicity. The realization that Pseudomonas aeruginosa, and a number of other pathogens, controls much of their virulence arsenal by means of extracellular signal molecules in a process denoted quorum sensing (QS) gave rise to a new ‘drug target rush’. Recently, QS has been shown to be involved in the development of tolerance to various antimicrobial treatments and immune modulation. The regulation of virulence via QS confers a strategic advantage over host defences. Consequently, a drug capable of blocking QS is likely to increase the susceptibility of the infecting organism to host defences and its clearance from the host. The use of QS signal blockers to attenuate bacterial pathogenicity, rather than bacterial growth, is therefore highly attractive, particularly with respect to the emergence of multi-antibiotic resistant bacteria.
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Cites
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Identification of the Cystic Fibrosis Gene: Genetic Analysis
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections
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Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosis
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Background
Cited by
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Self-citationThe biology and future prospects of antivirulence therapies
Cegelski, L., Marshall, G. R., Eldridge, G. R., & Hultgren, S. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1818 · Cited by 788
Streptococcus Adherence and Colonization
Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-09 · Cited by 657
Plant-Derived Antimicrobial Compounds: Alternatives to Antibiotics
Savoia, D. (2012) · Future Microbiology · doi:10.2217/fmb.12.68 · Cited by 601
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Metadata
- Authors
- Bjarnsholt, T., & Givskov, M.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2007-03-13
- Volume
- 362
- Issue
- 1483
- Pages
- 1213-1222
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2131230616
- Cited by
- 187
- References
- 7
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Bjarnsholt, T., & Givskov, M. (2007). Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Philosophical Transactions of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rstb.2007.2046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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