The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.
Plant-Derived Antimicrobial Compounds: Alternatives to Antibiotics
Abstract
The increasing incidence of drug-resistant pathogens has drawn the attention of the pharmaceutical and scientific communities towards studies on the potential antimicrobial activity of plant-derived substances, an untapped source of antimicrobial chemotypes, which are used in traditional medicine in different countries. The aim of this review is to provide recent insights regarding the possibilities of the most important natural antimicrobial compounds derived from plant sources containing a wide variety of secondary metabolites, which are useful as alternative strategies to control infectious diseases. This review will focus on natural plant products as a useful source of antimicrobial molecules, active in particular, on bacteria and fungi. When considering that many of these compounds, which have been used for centuries, are a source of new drugs and that there are ever-increasing technical breakthroughs, it can be envisaged that in the next years some different molecules discovered by ingenious screening programs and obtained from different plant oils and extracts will become useful therapeutic tools.
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Cites
Plant Products as Antimicrobial Agents
Cowan, M. M. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.4.564 · Cited by 9,043
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Natural products as sources of new drugs over the 30 years from 1981 to 2010
Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
Antibiotics for Emerging Pathogens
Fischbach, M. A., & Walsh, C. T. (2009) · Science · doi:10.1126/science.1176667 · Cited by 1,777
Recent advances in understanding the antibacterial properties of flavonoids
Cushnie, T. P. T., & Lamb, A. J. (2011) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2011.02.014 · Cited by 1,344
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Stermitz, F. R., Lorenz, P., Tawara, J. N., Zenewicz, L. A., & Lewis, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.030540597 · Cited by 761
Preformed Antimicrobial Compounds and Plant Defense against Fungal Attack.
Osbourn, A. E. (1996) · The Plant Cell · doi:10.1105/tpc.8.10.1821 · Cited by 729
Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?
Newman, D. J. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm0704090 · Cited by 716
Research works printed but not linked: 25
- 10.1016/j.ijantimicag.2011.09.018 · doi:10.1016/j.ijantimicag.2011.09.018
- 10.2307/3870232 · doi:10.2307/3870232 · Paper page
- 10.1021/np2003319 · doi:10.1021/np2003319
- 10.3923/pjbs.2010.452.455 · doi:10.3923/pjbs.2010.452.455
- 10.1089/jmf.2010.0251 · doi:10.1089/jmf.2010.0251
- 10.3390/molecules161210479 · doi:10.3390/molecules161210479
- 10.1055/s-2002-23128 · doi:10.1055/s-2002-23128
- 10.1016/j.phytochem.2005.04.023 · doi:10.1016/j.phytochem.2005.04.023
- 10.1007/s10096-007-0379-0 · doi:10.1007/s10096-007-0379-0
- 10.1021/np800148w · doi:10.1021/np800148w
- 10.1016/j.ijantimicag.2010.10.020 · doi:10.1016/j.ijantimicag.2010.10.020
- Zucca M CrivellaroS SavoiaD. New trends in the inhibition of Pseudomonas aeruginosa quorum sensing activity. In: Cystic Fibrosis: Etiology Diagnosis and Treatments. Leatte PN (Ed.). Nova Publishing NY USA 1–9 (2009).
- 10.1016/j.bmcl.2009.08.095 · doi:10.1016/j.bmcl.2009.08.095
- 10.1179/joc.2007.19.4.388 · doi:10.1179/joc.2007.19.4.388
- 10.1086/591916 · doi:10.1086/591916
- 10.2174/187152109789760117 · doi:10.2174/187152109789760117
- 10.1016/j.bmc.2011.11.052 · doi:10.1016/j.bmc.2011.11.052
- 10.1093/jac/dks007 · doi:10.1093/jac/dks007
- 10.1111/j.1365-2672.2008.04135.x · doi:10.1111/j.1365-2672.2008.04135.x
- Shafagha A , ShafaghatlonbarM. Antimicrobial activity and chemical constituents of the essential oils from flower, leaf and stem of Gypsophila bicolor from Iran. Nat. Prod. Commun.6 , 275–276 (2011).
- 10.1515/znc-2010-11-1202 · doi:10.1515/znc-2010-11-1202
- 10.1142/S0192415X10008421 · doi:10.1142/s0192415x10008421
- Falconieri D , PirasA, PorceddaS et al. Chemical composition and biological activity of the volatile extracts of Achillea millefolium. Nat. Prod. Commun. 6 , 1527–1530 (2011).
- 10.1089/jmf.2010.0298 · doi:10.1089/jmf.2010.0298
- 10.1089/jmf.2011.0128 · doi:10.1089/jmf.2011.0128
Cited by
Bacteriocins—A viable alternative to antibiotics?
Cotter, P. D., Ross, R. P., & Hill, C. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2937 · Cited by 1,793
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Ajibola, O. O. (2025) · Discover Food · doi:10.1007/s44187-025-00746-3 · Cited by 6
“Phytochemicals are bioactive compounds found in fruits and plants that have a variety of physiological effects, and some offer therapeutic value when consumed as part of a daily diet or used as medicinal agents [71].”
Metadata
- Authors
- Savoia, D.
- Venue
- Future Microbiology
- Publisher
- Informa UK Limited
- Published
- 2012-08
- Volume
- 7
- Issue
- 8
- Pages
- 979-990
- ISSN
- 1746-0913 (ISSN-L)
- 1746-0921
- OpenAlex
- W2161638921
- Cited by
- 601
- References
- 105
- FWCI
- 29.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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