The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence
Open accessAbstract
The most significant social behaviour of the lactating mother is maternal behaviour, which comprises maternal care and maternal aggression (MA). The latter is a protective behaviour of the mother serving to defend the offspring against a potentially dangerous intruder. The extent to which the mother shows aggressive behaviour depends on extrinsic and intrinsic factors, as we have learned from studies in laboratory rodents. Among the extrinsic factors are the pups’ presence and age, as well as the intruders’ sex and age. With respect to intrinsic factors, the mothers’ innate anxiety and the prosocial brain neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) play important roles. While OXT is well known as a maternal neuropeptide, AVP has only recently been described in this context. The increased activities of these neuropeptides in lactation are the result of remarkable brain adaptations peripartum and are a prerequisite for the mother to become maternal. Consequently, OXT and AVP are significantly involved in mediating the fine-tuned regulation of MA depending on the brain regions. Importantly, both neuropeptides are also modulators of anxiety, which determines the extent of MA. This review provides a detailed overview of the role of OXT and AVP in MA and the link to anxiety.
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“Maternal defensive aggression toward intruders also involves oxytocin”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Bosch 2013
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“Central OT and AVP signalling also modulate the expression of maternal aggression in defence of pups (5).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [5]
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The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Oxytocin, Neural Plasticity, and Social Behavior
Froemke, R. C., & Young, L. J. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102320-102847 · Cited by 480
“Maternal defensive aggression toward intruders also involves oxytocin (Bosch 2013).”
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Metadata
- Authors
- Bosch, O. J.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Bosch, Oliver J.
- ORCID
- Bosch, Oliver J.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2013-12-05
- Volume
- 368
- Issue
- 1631
- Pages
- 20130085
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC3826214
- OpenAlex
- W2170773257
- Cited by
- 194
- References
- 128
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 18 · 2023: 17 · 2022: 17 · 2021: 18 · 2020: 12 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 16 · 2014: 11 · 2013: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
- Keywords
- maternal aggression, maternal behavior, oxytocin, vasopressin, anxiety, lactation, intruder aggression, maternal care, neuropeptides, rodents
- MeSH terms
- Aggression, Amygdala, Animals, Animals, Newborn, Arginine Vasopressin, Female, Lactation, Male, Maternal Behavior, Oxytocin, Pregnancy, Mice, Rats
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