Both oxytocin and vasopressin are mediators of maternal care and aggression in rodents: From central release to sites of action
Abstract
In the mammalian peripartum period, the activity of both the brain oxytocin and vasopressin system is elevated as part of the physiological adaptations occurring in the mother. This is reflected by increased expression and intracerebral release of oxytocin and vasopressin, as well as increased neuropeptide receptor expression and binding. In this review we discuss the functional role of the brain oxytocin and vasopressin system in the context of maternal behavior, specifically maternal care and maternal aggression in rodents. In order to enable the identification of significant and peptide-specific contributions to the display of maternal behavior, various complementary animal models of maternal care and/or maternal aggression were studied, including rats selectively bred for differences in anxiety-related behavior (HAB and LAB dams), monitoring of local neuropeptide release during ongoing maternal behavior, and local pharmacological or genetic manipulations of the neuropeptide systems. The medial preoptic area was identified as a major site for oxytocin- and vasopressin-mediated maternal care. Furthermore, both oxytocin and vasopressin release and receptor activation in the central amygdala and the bed nucleus of the stria terminalis play an important role for maternal aggression. This article is part of a Special Issue entitled Oxytocin, Vasopressin, and Social Behavior.
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OT has been implicated in the onset of parental nurturing and maternal bonds, the consequences of parenting on the developing brain, pair bonding, empathy-based consoling behavior, and the consequences of social loss in animal models.
“Specifically, the neuropeptide oxytocin (OT) has been implicated in the onset of parental nurturing and maternal bonds (Bosch and Neumann 2012; Numan and Young 2016; Rilling and Young 2014), the consequences of parenting on the developing brain (Champagne et al. 2001; Barrett et al. 2015), pair bonding (Johnson et al. 2016; Johnson and Young 2015), empathy-based consoling behavior (Burkett et al.”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Bosch and Neumann 2012
The arginine vasopressin/oxytocin and dopamine systems closely interact in a site- and sex-specific manner to mediate partner preference formation, and similar cross-talk may also determine parenting styles.
“Current concepts hold that the AVP/OXT and DA systems closely interact in a site-and sex-specific manner to mediate partner preference formation, and similar cross-talk may also determine parenting styles (17).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [17]
The use of microdialysis to measure regionally-specific neuronal release of neuropeptides has provided important mechanistic insights into neuropeptide modulation in a variety of species and social contexts.
“The use of microdialysis to measure regionally-specific neuronal release of neuropeptides has provided important mechanistic insights into neuropeptide modulation in a variety of species and a host of social contexts, including maternal behavior, social recognition, social preference, social reward, social memory, and social buffering (Bosch and Neumann, 2012; Dölen et al., 2013; Dumais et al., 20”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Bosch and Neumann, 2012
OT regulates maternal aggression toward intruders in rodents as part of maternal care.
“OT also regulates maternal aggression toward intruders in rodents as part of maternal care (Bosch and Neumann 2012).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Bosch and Neumann 2012
Maternal aggression peaks during lactation.
“Maternal aggression peaks during lactation, suggesting oxytocin may regulate this behavior (see review Bosch and Neumann, 2012).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Bosch and Neumann, 2012
Oxytocin may regulate maternal aggression.
“suggesting oxytocin may regulate this behavior (see review Bosch and Neumann, 2012).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Bosch and Neumann, 2012
Endogenous oxytocin release in the rodent brain correlates with aggression in mate-guarding behavior and with maternal aggression in defending offspring against intruders.
“This more differentiated view is also supported by animal studies showing that endogenous OT release in the rodent brain correlates with aggression in mate-guarding behavior (Bales and Carter, 2003) and with maternal aggression in defending offspring against intruders (Bosch, 2005; Bosch and Neumann, 2012).”
From Oxytocin promotes altruistic punishment (2017) · cites this paper as Bosch and Neumann, 2012
Animal studies show OT's role in triggering maternal aggression toward intruders or toward potential dangers to offspring.
“This is also congruent with animal studies showing OT’s role in triggering maternal aggression toward intruders or toward potential dangers to offspring (Bosch, 2005; Bosch and Neumann, 2012).”
From Oxytocin promotes altruistic punishment (2017) · cites this paper as Bosch and Neumann, 2012
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Self-citationA precision medicine approach to oxytocin trials
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Olazábal, D. E. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.10.002 · Cited by 35 · see citing works
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Luo, P. X., Zakharenkov, H. C., Torres, L. Y., Rios, R. A., Gegenhuber, B., Black, A. M., Xu, C. K., Minie, V. A., Tran, A. M., Tollkuhn, J., et al. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105203 · Cited by 27 · see citing works
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Oxytocin receptor ligands induce changes in cytoskeleton in neuroblastoma cells
Bakos, J., Strbak, V., Paulikova, H., Krajnakova, L., Lestanova, Z., & Bacova, Z. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9960-4 · Cited by 18 · see citing works
- Authors
- Bosch, O. J., & Neumann, I. D.
- Affiliations
- University of Regensburg (DE)
- Corresponding author
- Bosch, Oliver J.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 61
- Issue
- 3
- Pages
- 293-303
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2062089118
- Cited by
- 400
- References
- 163
- Citations by year
- 2026: 23 · 2025: 15 · 2024: 20 · 2023: 15 · 2022: 15 · 2021: 29 · 2020: 15 · 2019: 28 · 2018: 36 · 2017: 38 · 2016: 33 · 2015: 42 · 2014: 39 · 2013: 32 · 2012: 19
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, vasopressin, maternal behavior, maternal care, maternal aggression, transition period, medial preoptic area, central amygdala, bed nucleus of the stria terminalis, neuropeptide receptors, anxiety-like behavior, rodents
- MeSH terms
- Aggression, Animals, Anxiety, Humans, Lactation, Maternal Behavior, Oxytocin, Septal Nuclei, Vasopressins, Receptors, Vasopressin, Receptors, Oxytocin, Rats
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