Cited by 194Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyAnimal Behavior and Reproduction

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Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence

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Bosch, Oliver J.·2013·Philosophical Transactions of the Royal Society B: Biological Sciences

DOI 10.1098/rstb.2013.0085PMC PMC3826214

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Abstract

The most significant social behaviour of the lactating mother is maternal behaviour, which comprises maternal care and maternal aggression (MA). The latter is a protective behaviour of the mother serving to defend the offspring against a potentially dangerous intruder. The extent to which the mother shows aggressive behaviour depends on extrinsic and intrinsic factors, as we have learned from studies in laboratory rodents. Among the extrinsic factors are the pups’ presence and age, as well as the intruders’ sex and age. With respect to intrinsic factors, the mothers’ innate anxiety and the prosocial brain neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) play important roles. While OXT is well known as a maternal neuropeptide, AVP has only recently been described in this context. The increased activities of these neuropeptides in lactation are the result of remarkable brain adaptations peripartum and are a prerequisite for the mother to become maternal. Consequently, OXT and AVP are significantly involved in mediating the fine-tuned regulation of MA depending on the brain regions. Importantly, both neuropeptides are also modulators of anxiety, which determines the extent of MA. This review provides a detailed overview of the role of OXT and AVP in MA and the link to anxiety.

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Authors: Bosch, O. J.
Affiliations: University of Regensburg (DE)
Corresponding author: Bosch, Oliver J.
ORCID: Bosch, Oliver J.
Venue: Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher: The Royal Society
Published: 2013-12-05
Volume: 368
Issue: 1631
Pages: 20130085
ISSN: 0962-8436 (ISSN-L)
1471-2970
DOI: 10.1098/rstb.2013.0085
PMC: PMC3826214
OpenAlex: W2170773257
Cited by: 194
References: 128
Citations by year: 2026: 7 · 2025: 7 · 2024: 18 · 2023: 17 · 2022: 17 · 2021: 18 · 2020: 12 · 2019: 16 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 16 · 2014: 11 · 2013: 4
FWCI: 2.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Locations: Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: maternal aggression, maternal behavior, oxytocin, vasopressin, anxiety, lactation, intruder aggression, maternal care, neuropeptides, rodents
MeSH terms: Aggression, Amygdala, Animals, Animals, Newborn, Arginine Vasopressin, Female, Lactation, Male, Maternal Behavior, Oxytocin, Pregnancy, Mice, Rats

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Maternal aggression in rodents: brain oxytocin and vasopressin mediate pup defence

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