Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 189

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing

Young, Andrew J.·2018·Philosophical Transactions of the Royal Society B: Biological Sciences
DOI 10.1098/rstb.2016.0452PMC PMC5784072
Open this paper in CoChat — free account

Abstract

Evolutionary biology and biomedicine have seen a surge of recent interest in the possibility that telomeres play a role in life-history trade-offs and ageing. Here, I evaluate alternative hypotheses for the role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing, and highlight outstanding challenges. First, while recent findings underscore the possibility of a proximate causal role for telomeres in current–future trade-offs and ageing, it is currently unclear (i) whether telomeres ever play a causal role in either and (ii) whether any causal role for telomeres arises via shortening or length-independent mechanisms. Second, I consider why, if telomeres do play a proximate causal role, selection has not decoupled such a telomere-mediated trade-off between current and future performance. Evidence suggests that evolutionary constraints have not rendered such decoupling impossible. Instead, a causal role for telomeres would more plausibly reflect an adaptive strategy, born of telomere maintenance costs and/or a function for telomere attrition (e.g. in countering cancer), the relative importance of which is currently unclear. Finally, I consider the potential for telomere biology to clarify the constraints at play in life-history evolution, and to explain the form of the current–future trade-offs and ageing trajectories that we observe today. This article is part of the theme issue ‘Understanding diversity in telomere dynamics’.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1098/rstb.2016.0452

Cites

18 of 18 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 84

  1. Stearns SC, 1992, The evolution of life-histories
  2. Roff DA, 2002, Life history evolution
  3. Bennett PM, 2002, Evolutionary ecology of birds. Life-histories, mating systems and extinction, 10.1093/oso/9780198510888.001.0001 · DOI
  4. 10.1038/270301a0 · DOI
  5. 10.1098/rstb.1991.0028 · DOI
  6. 10.1017/9781139939867.002 · DOI
  7. 10.1111/j.1558-5646.1957.tb02911.x · DOI · Paper page
  8. 10.1098/rspb.2015.0209 · DOI
  9. 10.1016/j.tree.2006.10.008 · DOI
  10. 10.1146/annurev.ecolsys.32.081501.114006 · DOI · Paper page
  11. 10.1086/284547 · DOI
  12. 10.1093/acprof:oso/9780199568765.001.0001 · DOI
  13. 10.1016/j.tree.2012.06.006 · DOI
  14. 10.1111/brv.12179 · DOI
  15. 10.1002/ece3.1790 · DOI
  16. 10.1016/j.tree.2005.11.007 · DOI
  17. 10.1111/j.1461-0248.2006.00989.x · DOI
  18. 10.1098/rspb.2015.1086 · DOI
  19. 10.1086/283488 · DOI
  20. 10.1086/285398 · DOI
  21. 10.1016/S0169-5347(01)02162-0 · DOI
  22. 10.1006/anbe.2003.2122 · DOI
  23. 10.1016/B978-012730055-9/50015-X · DOI
  24. 10.1098/rstb.2010.0275 · DOI
  25. 10.1016/S0092-8674(01)00492-5 · DOI
  26. 10.1016/j.tibs.2005.05.004 · DOI
  27. 10.1126/science.1170633 · DOI · Paper page
  28. 10.1128/MMBR.66.3.407-425.2002 · DOI · Paper page
  29. 10.1016/j.exger.2015.08.012 · DOI
  30. 10.1371/journal.pone.0108964 · DOI
  31. 10.1098/rspb.2009.0517 · DOI
  32. 10.1098/rstb.2016.0447 · DOI
  33. 10.1098/rstb.2016.0449 · DOI
  34. 10.1098/rstb.2016.0446 · DOI
  35. 10.1007/s10522-009-9216-4 · DOI
  36. 10.1111/j.1365-294X.2011.05331.x · DOI
  37. 10.1111/mec.13857 · DOI
  38. 10.1073/pnas.1113306109 · DOI · Paper page
  39. 10.1098/rspb.2012.2540 · DOI
  40. Wood E, 2017, Causes and fitness consequences of telomere dynamics in a wild social bird
  41. 10.1242/jeb.090043 · DOI
  42. 10.1098/rsbl.2015.0396 · DOI
  43. 10.1038/cr.2008.74 · DOI
  44. 10.1098/rstb.2016.0445 · DOI
  45. 10.1007/s00300-015-1766-0 · DOI
  46. 10.1111/acel.12050 · DOI · Paper page
  47. 10.1016/j.arr.2015.08.002 · DOI · Paper page
  48. 10.1098/rstb.2016.0440 · DOI
  49. 10.1098/rspb.2013.3287 · DOI
  50. 10.1371/journal.pbio.2000016 · DOI
  51. 10.1136/jmedgenet-2014-102736 · DOI
  52. 10.1098/rspb.2014.2263 · DOI
  53. 10.1158/2159-8290.CD-16-0062 · DOI · Paper page
  54. 10.1111/j.1474-9726.2007.00281.x · DOI
  55. 10.1371/journal.pgen.0030224 · DOI
  56. 10.1111/acel.12417 · DOI
  57. 10.1111/acel.12555 · DOI
  58. 10.1111/1365-2435.12764 · DOI
  59. 10.1016/j.exger.2007.03.004 · DOI
  60. 10.1016/j.mad.2008.02.008 · DOI
  61. 10.1016/j.celrep.2012.08.023 · DOI
  62. 10.7554/eLife.19130 · DOI · Paper page
  63. 10.1073/pnas.1100278108 · DOI
  64. 10.1098/rstb.2016.0450 · DOI
  65. 10.1111/j.1474-9726.2011.00775.x · DOI
  66. 10.1371/journal.pgen.1004351 · DOI
  67. 10.1038/nrg.2017.26 · DOI
  68. 10.1002/ajhb.21127 · DOI
  69. 10.1098/rstb.2016.0443 · DOI
  70. 10.1098/rstb.2016.0448 · DOI
  71. 10.1098/rstb.2014.0219 · DOI · Paper page
  72. 10.1016/j.tree.2013.07.005 · DOI
  73. 10.1038/nrc1016 · DOI
  74. 10.1158/0008-5472.CAN-11-0342 · DOI
  75. 10.1093/jnci/59.1.185 · DOI
  76. 10.1016/j.tree.2011.01.002 · DOI
  77. 10.1098/rspb.2006.3480 · DOI
  78. 10.1098/rspb.2014.2140 · DOI
  79. 10.1098/rstb.2016.0438 · DOI · Paper page
  80. 10.1038/nrg3743 · DOI
  81. 10.1530/JOE-16-0054 · DOI
  82. 10.1016/S0300-9084(75)80139-8 · DOI
  83. 10.1073/pnas.76.9.4507 · DOI
  84. 10.1016/j.ceb.2012.09.004 · DOI

Cited by

See all 189

Metadata

Authors
Young, A. J.
Venue
Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher
The Royal Society
Published
2018-01-15
Volume
373
Issue
1741
Pages
20160452
ISSN
  • 0962-8436
  • 1471-2970
DOI
10.1098/rstb.2016.0452
PMC
PMC5784072
Cited by
189
References
18
Language
en
Licence
royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
Funders
Biotechnology and Biological Sciences Research Council (BB/H022716/1)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review