Rickettsia felis: molecular characterization of a new member of the spotted fever group.
Abstract
In this report, placement of Rickettsia felis in the spotted fever group (SFG) rather than the typhus group (TG) of Rickettsia is proposed. The organism, which was first observed in cat fleas (Ctenocephalides felis) by electron microscopy, has not yet been reported to have been cultivated reproducibly, thereby limiting the standard rickettsial typing by serological means. To overcome this challenge, several genes were selected as targets to be utilized for the classification of R. felis. DNA from cat fleas naturally infected with R. felis was amplified by PCR utilizing primer sets specific for the 190 kDa surface antigen (rOmpA) and 17 kDa antigen genes. The entire 5,513 bp rompA gene was sequenced, characterized and found to have several unique features when compared to the rompA genes of other Rickettsia. Phylogenetic analysis of the partial sequence of the 17 kDa antigen gene indicated that R. felis is less divergent from the SFG rickettsiae than from the TG rickettsiae. The data corroborate results from previous reports that analysed the citrate synthase, 16S rRNA, rompB (135 kDa surface antigen), metK, ftsY, polA and dnaE genes that placed R. felis as a member of the SFG. The organism is passed trans-stadially and transovarially, and infection in the cat flea has been observed in the midgut, tracheal matrix, muscle, hypodermis, ovaries and testes.
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Rickettsia felis is a pathogen mainly transmitted by the cat flea and suspected to induce a murine typhus-like illness in humans, and it is worldwide distributed due to the global dispersion of C. felis, the number of infected cats and the possibility of transstadial and transovarial transmission in fleas.
“Rickettsia felis, a pathogen mainly transmitted by the cat flea [34] and suspected to induce a murine typhus-like illness in humans, is worldwide distributed, due to the global dispersion of C. felis, the number of infected cats and the possibility of transstadial and transovarial transmission in fleas [35-37].”
From Fleas infesting pets in the era of emerging extra-intestinal nematodes (2013) · cites this paper as [34]
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Isolation ofRickettsia felisin the Mosquito Cell Line C6/36
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Self-citationVariations of Plasmid Content in Rickettsia felis
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Cross-protection between distantly related spotted fever group rickettsiae
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Self-citationRickettsia felisin the United Kingdom
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Tick-borne Rickettsiales: Molecular tools for the study of an emergent group of pathogens
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Spotted Fever Group Rickettsioses
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Self-citationClinical and laboratorial evidence of Rickettsia felis infections in Latin America
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Rickettsia typhi (Murine Typhus)
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TRANSCRIPTION OF THE RICKETTSIA FELIS OMPA GENE IN NATURALLY INFECTED FLEAS
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Self-citationMolecular survey of Rickettsial organisms in ectoparasites from a dog shelter in Northern Mexico
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- Authors
- Bouyer, D. H., Stenos, J., Crocquet-Valdes, P., Moron, C. G., Popov, V. L., Zavala-Velazquez, J. E., Foil, L. D., Stothard, D. R., Azad, A. F., & Walker, D. H.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- International Journal of Systematic and Evolutionary Microbiology
- Publisher
- Microbiology Society
- Published
- 2001-03-01
- Volume
- 51
- Issue
- 2
- Pages
- 339-347
- ISSN
- 1466-5026 (ISSN-L)
- 1466-5034
- OpenAlex
- W2145015532
- Cited by
- 136
- References
- 40
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 10 · 2013: 3 · 2012: 9
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (publishedVersion)
- PubMed (publishedVersion)
- Civil War Book Review (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI31431, AI21242, R01AI021242)
- Fogarty International Center (D43 TW00903, D43TW000903)
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect symbiosis and bacterial influences
- Life Sciences › Immunology and Microbiology › Parasitology › Bartonella species infections research
- Keywords
- Rickettsia felis, spotted fever group
- MeSH terms
- Animals, Bacterial Outer Membrane Proteins, Boutonneuse Fever, Cats, Siphonaptera, Intestinal Mucosa, Molecular Sequence Data, Terminology as Topic, Rickettsia
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