The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Fusobacterium nucleatum supports the growth of Porphyromonas gingivalis in oxygenated and carbon-dioxide-depleted environments
Abstract
The authors compared the differences in tolerance to oxygen of the anaerobic periodontopathic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis, and explored the possibility that F. nucleatum might be able to support the growth of P. gingivalis in aerated and CO 2-depleted environments. Both micro-organisms were grown as monocultures and in co-culture in the presence and absence of CO 2 and under different aerated conditions using a continuous culture system. At steady state, viable counts were performed and the activities of the enzymes superoxide dismutase and NADH oxidase/peroxidase were assayed in P. gingivalis. In co-culture,F. nucleatum was able to support the growth of P. gingivalis in aerated and CO 2-depleted environments in which P. gingivalis, as a monoculture, was not able to survive.F. nucleatum not only appeared to have a much higher tolerance to oxygen than P. gingivalis, but a significant increase in its numbers occurred under moderately oxygenated conditions.F. nucleatum might have an additional indirect role in dental plaque maturation, contributing to the reducing conditions necessary for the survival of P. gingivalis and possibly other anaerobes less tolerant to oxygen. Additionally,F. nucleatum is able to generate a capnophilic environment essential for the growth of P. gingivalis.
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“Fusobacterium nucleatum and A actinomycetemcomitans are well recognized in periodontal disease,220, 221 and F nucleatum is noted for its role in the development of anaerobic microenvironments that facilitate the outgrowth of anaerobic periodontal pathogens.222”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [222]
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Cites
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Life Below the Gum Line: Pathogenic Mechanisms ofPorphyromonas gingivalis
Lamont, R. J., & Jenkinson, H. F. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1244-1263.1998 · Cited by 964
Comparison of the microbiota of supra‐ and subgingival plaque in health and periodontitis
Ximenez‐Fyvie, L., Haffajee, A. D., & Socransky, S. S. (2000) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2000.027009648.x · Cited by 577
Han, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3140-3146.2000 · Cited by 435
DNA strand scission by enzymically generated oxygen radicals
Brawn, K., & Fridovich, I. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90108-9 · Cited by 423
Assay of metabolic superoxide production in Escherichia coli.
Imlay, J. A., & Fridovich, I. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89596-9 · Cited by 420
Evidence of bacterial etiology: a historical perspective
Socransky, S. S., & Haffajee, A. D. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00016.x · Cited by 375
Bradshaw, D. J., Marsh, P. D., Watson, G. K., & Allison, C. (1998) · Infection and Immunity · doi:10.1128/iai.66.10.4729-4732.1998 · Cited by 351
Kolenbrander, P. E., Andersen, R. N., & Moore, L. V. (1989) · Infection and Immunity · doi:10.1128/iai.57.10.3194-3203.1989 · Cited by 298
Research works printed but not linked: 1
- Massol-Deya, 1994, Biofilm architecture: a fortuitous engineering feature, ASM News, 60, 406
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Abid, Z., Imran, N. K., & Agha, M. T. (2025) · Lasers in Dental Science · doi:10.1007/s41547-025-00278-0 · Cited by 2
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Endo, M., Domon, H., Hirayama, S., Takizawa, F., USHIDA, A., Tabeta, K., & Terao, Y. (2025) · PLoS ONE · doi:10.1371/journal.pone.0334259 · Cited by 1
Effect of Smoking on Subgingival Microbiome in Chronic Periodontitis: A 16S rRNA Sequencing Study
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Cao, D., Ammad, M., Subhadra, B., Panda, M. K., Inzana, T. J., Cunha, F., Casaro, S., Jones, K. L., Ramírez-Hernández, R., Bromfield, J. J., et al. (2026) · Microbiome · doi:10.1186/s40168-025-02320-6 · Cited by 1
Nicotine is a potent extracellular polysaccharide inducer in Fusobacterium nucleatum biofilms
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Hickl, J., Argyropoulou, A., Al‐Ahmad, A., Hellwig, E., Skaltsounis, A., Wittmer, A., Vach, K., & Karygianni, L. (2023) · Research Square · doi:10.21203/rs.3.rs-3331523/v1 · Cited by 1
Agrupaciones Familiares en Periodontitis Crónica
Medina, C. M. A., & Guzmán, I. C. (2011) · Revista Archivo Médico de Camagüey
Haraldsson, G. (2005) · Työväentutkimus Vuosikirja
Neutrophil Responses to Mixed-Species Anaerobic Biofilms
Lockhart, J. (2015) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/27088
vorgelegt dem Rat der Medizinischen Fakultät der
Jena, F.-S.-U., & Senft, N. (2011)
Long in the tooth: Oral bacterial communities and chronic periodontitis
Dashper, S. G., Byrne, S. J., Orth, R., & Reynolds, E. C. (2007) · Microbiology Australia · doi:10.1071/ma07113
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Yang, X. (2007) · UWSpace (University of Waterloo)
Bendyk, A. (2008) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
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Robo, S. (2018) · International Journal of Biomedical Engineering and Clinical Science · doi:10.11648/j.ijbecs.20180402.14
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Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water
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Adjuvant Effect of Probiotics in the Treatment of Periodontal and Peri-Implant Diseases
Barbagallo, G., Monaca, G., Gregorio, F. D., Alì, G., Porto, V., & Assenza, G. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005784
Bachtiar, B. M., Rieuwpassa, I. E., Susilowati, H., Indrawati, R., Theodorea, C. F., Fath, T., & Bachtiar, E. W. (2025) · Frontiers in Dental Medicine · doi:10.3389/fdmed.2025.1545479
Martin, P. L., Rousseau, C. D., & Farouk, A. S. (2022) · Journal of Current Research in Oral Surgery · doi:10.51847/joxxl5kepx
Microbial study of periodontal diseases
Benabdelkader, S. (2019) · theses.fr (ABES) · doi:10.70675/ceca4a2fz6c83z4970zad35z921640cd968e
Maladie parodontale, microbiote et fer
Boyer, É. (2019) · theses.fr (ABES) · doi:10.70675/3b7abb28zaa4ez4ab7z83e3z6a9e644dd83f
Overview of head & neck microbiota
Jayasinghe, R., Gunawardhana, K. S. N. D., & Senevirathna, K. (2026) · Advances in immunology · doi:10.1016/bs.ai.2026.04.003
Bandi, D. P., Krishnaswamy, B., & Victor, D. J. (2026) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2026.101479
Adil, S. S. B. M. Y., Tucci, J. D., Dashper, S. G., Irving, H. R., & Kabwe, M. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2726627
Effects of Micro- and Nanoplastics on Human Saliva– and Dental Plaque–Derived Biofilms
Jieyu, Z., Muxin, X., Lan, L., Haiyun, D., Shao, Y., Sun, Y., Pan, Y., & Zhang, K. (2026) · International Dental Journal · doi:10.1016/j.identj.2026.111135
Kaplan, J. B., Sawaed, W., Katz, A. Z., Rysin, R., Kogan, L., Rohde, H., & Kridin, K. (2026) · Microbiology Research · doi:10.3390/microbiolres17110216
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Hernández, J. F. O., Sánchez, D. N. L., & Reyes, L. M. U. (2026) · Revista de la Asociación Dental Mexicana · doi:10.35366/124527
Metadata
- Authors
- Diaz, P. I., Zilm, P. S., & Rogers, A. H.
- Affiliations
- Adelaide University (AU)
- Corresponding author
- Rogers, A. H
- ORCID
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2002-02-01
- Volume
- 148
- Issue
- 2
- Pages
- 467-472
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2125265838
- Cited by
- 241
- References
- 23
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 16 · 2023: 19 · 2022: 12 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 3 · 2012: 10
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Australian Dental Research Foundation
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Fusobacterium nucleatum, Porphyromonas gingivalis, bacterial co-culture, oxygen tolerance, periodontal pathogens, superoxide dismutase, NADH oxidase, peroxidase, anaerobic bacteria
- MeSH terms
- Adaptation, Physiological, Anaerobiosis, Carbon Dioxide, Dental Plaque, Humans, Microscopy, Electron, Scanning, Multienzyme Complexes, NADH, NADPH Oxidoreductases, Oxygen, Peroxidases, Superoxide Dismutase, Porphyromonas gingivalis, Fusobacterium nucleatum, Biofilms
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