The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Fusobacterium nucleatum supports the growth of Porphyromonas gingivalis in oxygenated and carbon-dioxide-depleted environments
Abstract
The authors compared the differences in tolerance to oxygen of the anaerobic periodontopathic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis, and explored the possibility that F. nucleatum might be able to support the growth of P. gingivalis in aerated and CO 2-depleted environments. Both micro-organisms were grown as monocultures and in co-culture in the presence and absence of CO 2 and under different aerated conditions using a continuous culture system. At steady state, viable counts were performed and the activities of the enzymes superoxide dismutase and NADH oxidase/peroxidase were assayed in P. gingivalis. In co-culture,F. nucleatum was able to support the growth of P. gingivalis in aerated and CO 2-depleted environments in which P. gingivalis, as a monoculture, was not able to survive.F. nucleatum not only appeared to have a much higher tolerance to oxygen than P. gingivalis, but a significant increase in its numbers occurred under moderately oxygenated conditions.F. nucleatum might have an additional indirect role in dental plaque maturation, contributing to the reducing conditions necessary for the survival of P. gingivalis and possibly other anaerobes less tolerant to oxygen. Additionally,F. nucleatum is able to generate a capnophilic environment essential for the growth of P. gingivalis.
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“Fusobacterium nucleatum and A actinomycetemcomitans are well recognized in periodontal disease,220, 221 and F nucleatum is noted for its role in the development of anaerobic microenvironments that facilitate the outgrowth of anaerobic periodontal pathogens.222”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [222]
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Cites
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Biogeography of a human oral microbiome at the micron scale
Mark Welch, J. L., Rossetti, B. J., Rieken, C. W., Dewhirst, F. E., & Borisy, G. G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522149113 · Cited by 968
Bacterial interactions and successions during plaque development
Kolenbrander, P. E., Palmer, R. J., Rickard, A. H., Jakubovics, N. S., Chalmers, N. I., & Diaz, P. I. (2006) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00187.x · Cited by 791
Self-citationBacterial coaggregation: an integral process in the development of multi-species biofilms
Rickard, A. H., Gilbert, P., High, N. J., Kolenbrander, P. E., & Handley, P. S. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00034-3 · Cited by 765
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
The role of the microbiota in periodontal disease
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020) · Periodontology 2000 · doi:10.1111/prd.12296 · Cited by 698
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Metadata
- Authors
- Diaz, P. I., Zilm, P. S., & Rogers, A. H.
- Affiliations
- Adelaide University (AU)
- Corresponding author
- Rogers, A. H
- ORCID
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2002-02-01
- Volume
- 148
- Issue
- 2
- Pages
- 467-472
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2125265838
- Cited by
- 241
- References
- 23
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 16 · 2023: 19 · 2022: 12 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 3 · 2012: 10
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Australian Dental Research Foundation
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Fusobacterium nucleatum, Porphyromonas gingivalis, bacterial co-culture, oxygen tolerance, periodontal pathogens, superoxide dismutase, NADH oxidase, peroxidase, anaerobic bacteria
- MeSH terms
- Adaptation, Physiological, Anaerobiosis, Carbon Dioxide, Dental Plaque, Humans, Microscopy, Electron, Scanning, Multienzyme Complexes, NADH, NADPH Oxidoreductases, Oxygen, Peroxidases, Superoxide Dismutase, Porphyromonas gingivalis, Fusobacterium nucleatum, Biofilms
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