Cited by 242Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingMicrobial infections and disease research

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Fusobacterium nucleatum supports the growth of Porphyromonas gingivalis in oxygenated and carbon-dioxide-depleted environments

Diaz, P. I, Zilm, P. S, Rogers, A. H·2002·Microbiology

DOI 10.1099/00221287-148-2-467

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Abstract

The authors compared the differences in tolerance to oxygen of the anaerobic periodontopathic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis, and explored the possibility that F. nucleatum might be able to support the growth of P. gingivalis in aerated and CO 2-depleted environments. Both micro-organisms were grown as monocultures and in co-culture in the presence and absence of CO 2 and under different aerated conditions using a continuous culture system. At steady state, viable counts were performed and the activities of the enzymes superoxide dismutase and NADH oxidase/peroxidase were assayed in P. gingivalis. In co-culture,F. nucleatum was able to support the growth of P. gingivalis in aerated and CO 2-depleted environments in which P. gingivalis, as a monoculture, was not able to survive.F. nucleatum not only appeared to have a much higher tolerance to oxygen than P. gingivalis, but a significant increase in its numbers occurred under moderately oxygenated conditions.F. nucleatum might have an additional indirect role in dental plaque maturation, contributing to the reducing conditions necessary for the survival of P. gingivalis and possibly other anaerobes less tolerant to oxygen. Additionally,F. nucleatum is able to generate a capnophilic environment essential for the growth of P. gingivalis.

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Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Life Below the Gum Line: Pathogenic Mechanisms ofPorphyromonas gingivalis
Lamont, R. J., & Jenkinson, H. F. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1244-1263.1998 · Cited by 964
Comparison of the microbiota of supra‐ and subgingival plaque in health and periodontitis
Ximenez‐Fyvie, L., Haffajee, A. D., & Socransky, S. S. (2000) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2000.027009648.x · Cited by 577
Interactions between Periodontal Bacteria and Human Oral Epithelial Cells: Fusobacterium nucleatum Adheres to and Invades Epithelial Cells
Han, Y. W., Shi, W., Huang, G. T.-J., Kinder Haake, S., Park, N.-H., Kuramitsu, H., & Genco, R. J. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3140-3146.2000 · Cited by 435
DNA strand scission by enzymically generated oxygen radicals
Brawn, K., & Fridovich, I. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90108-9 · Cited by 423
Assay of metabolic superoxide production in Escherichia coli.
Imlay, J. A., & Fridovich, I. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89596-9 · Cited by 420
Evidence of bacterial etiology: a historical perspective
Socransky, S. S., & Haffajee, A. D. (1994) · Periodontology 2000 · doi:10.1111/j.1600-0757.1994.tb00016.x · Cited by 375
Role of Fusobacterium nucleatum and Coaggregation in Anaerobe Survival in Planktonic and Biofilm Oral Microbial Communities during Aeration
Bradshaw, D. J., Marsh, P. D., Watson, G. K., & Allison, C. (1998) · Infection and Immunity · doi:10.1128/iai.66.10.4729-4732.1998 · Cited by 351
Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria
Kolenbrander, P. E., Andersen, R. N., & Moore, L. V. (1989) · Infection and Immunity · doi:10.1128/iai.57.10.3194-3203.1989 · Cited by 298

Show all 23 references

Research works printed but not linked: 1

Massol-Deya, 1994, Biofilm architecture: a fortuitous engineering feature, ASM News, 60, 406

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Authors: Diaz, P. I., Zilm, P. S., & Rogers, A. H.
Affiliations: Adelaide University (AU)
Corresponding author: Rogers, A. H
ORCID: Diaz, P. I
Zilm, P. S
Venue: Microbiology
Publisher: Microbiology Society
Published: 2002-02-01
Volume: 148
Issue: 2
Pages: 467-472
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/00221287-148-2-467
OpenAlex: W2125265838
Cited by: 241
References: 23
Citations by year: 2026: 8 · 2025: 20 · 2024: 16 · 2023: 19 · 2022: 12 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 12 · 2017: 6 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 3 · 2012: 10
FWCI: 5.95
Type: journal article
Language: en
Open access: closed
Locations: Microbiology (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Australian Dental Research Foundation
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: Fusobacterium nucleatum, Porphyromonas gingivalis, bacterial co-culture, oxygen tolerance, periodontal pathogens, superoxide dismutase, NADH oxidase, peroxidase, anaerobic bacteria
MeSH terms: Adaptation, Physiological, Anaerobiosis, Carbon Dioxide, Dental Plaque, Humans, Microscopy, Electron, Scanning, Multienzyme Complexes, NADH, NADPH Oxidoreductases, Oxygen, Peroxidases, Superoxide Dismutase, Porphyromonas gingivalis, Fusobacterium nucleatum, Biofilms

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Fusobacterium nucleatum supports the growth of Porphyromonas gingivalis in oxygenated and carbon-dioxide-depleted environments

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