Cited by 2,094Gut microbiota and healthGenomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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Derrien, Muriel, Vaughan, Elaine E., Plugge, Caroline M., de Vos, Willem M.·2004·International Journal of Systematic and Evolutionary Microbiology

DOI 10.1099/ijs.0.02873-0

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Abstract

The diversity of mucin-degrading bacteria in the human intestine was investigated by combining culture and 16S rRNA-dependent approaches. A dominant bacterium, strain Muc T , was isolated by dilution to extinction of faeces in anaerobic medium containing gastric mucin as the sole carbon and nitrogen source. A pure culture was obtained using the anaerobic soft agar technique. Strain Muc T was a Gram-negative, strictly anaerobic, non-motile, non-spore-forming, oval-shaped bacterium that could grow singly and in pairs. When grown on mucin medium, cells produced a capsule and were found to aggregate. Strain Muc T could grow on a limited number of sugars, including N -acetylglucosamine, N -acetylgalactosamine and glucose, but only when a protein source was provided and with a lower growth rate and final density than on mucin. The G+C content of DNA from strain Muc T was 47·6 mol%. 16S rRNA gene sequence analysis revealed that the isolate was part of the division Verrucomicrobia . The closest described relative of strain Muc T was Verrucomicrobium spinosum (92 % sequence similarity). Remarkably, the 16S rRNA gene sequence of strain Muc T showed 99 % similarity to three uncultured colonic bacteria. According to the data obtained in this work, strain Muc T represents a novel bacterium belonging to a new genus in subdivision 1 of the Verrucomicrobia ; the name Akkermansia muciniphila gen. nov., sp. nov. is proposed; the type strain is Muc T (=ATCC BAA-835 T =CIP 107961 T ).

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Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA
Muyzer, G., de Waal, E. C., & Uitterlinden, A. G. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.695-700.1993 · Cited by 11,490
Nucleic acid techniques in bacterial systematics
Stackebrandt, E. S., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,460
16S/23S rRNA sequencing
Lane, D. (1991) · Medical Entomology and Zoology · Cited by 8,190
ARB: a software environment for sequence data
Ludwig, W. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh293 · Cited by 6,714
Precise Measurement of the G+C Content of Deoxyribonucleic Acid by High-Performance Liquid Chromatography
MESBAH, M., PREMACHANDRAN, U., & Whitman, W. B. (1989) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-39-2-159 · Cited by 4,534
Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity
Hugenholtz, P., Goebel, B. M., & Pace, N. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4765-4774.1998 · Cited by 2,429
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490
Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360
Sequence heterogeneities of genes encoding 16S rRNAs in Paenibacillus polymyxa detected by temperature gradient gel electrophoresis
Nübel, U., Engelen, B., Felske, A., Snaidr, J., Wieshuber, A., Amann, R., Ludwig, W., & Backhaus, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5636-5643.1996 · Cited by 1,356

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Authors: Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M.
Affiliations: Wageningen University & Research (NL)
Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands
ORCID: Derrien, Muriel
Vaughan, Elaine E.
Plugge, Caroline M.
Venue: International Journal of Systematic and Evolutionary Microbiology
Publisher: Microbiology Society
Published: 2004-09-01
Volume: 54
Issue: 5
Pages: 1469-1476
ISSN: 1466-5026 (ISSN-L)
1466-5034
DOI: 10.1099/ijs.0.02873-0
OpenAlex: W2134241692
Cited by: 2,094
References: 37
Citations by year: 2026: 157 · 2025: 190 · 2024: 212 · 2023: 200 · 2022: 230 · 2021: 197 · 2020: 180 · 2019: 160 · 2018: 110 · 2017: 96 · 2016: 103 · 2015: 63 · 2014: 52 · 2013: 36 · 2012: 28
FWCI: 2.47
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords: Akkermansia muciniphila, novel bacterial genus
MeSH terms: Acetylgalactosamine, Acetylglucosamine, Base Composition, Carbon, Culture Media, DNA, Bacterial, DNA, Ribosomal, Feces, Gastric Mucins, Glucose, Gram-Negative Anaerobic Bacteria, Humans, Intestines, Molecular Sequence Data, Movement, Nitrogen, Phylogeny, RNA, Bacterial, RNA, Ribosomal, 16S, Spores, Bacterial, Bacterial Capsules, Sequence Analysis, DNA, Genes, rRNA

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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