Cited by 2,094Gut microbiota and healthGenomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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Derrien, Muriel, Vaughan, Elaine E., Plugge, Caroline M., de Vos, Willem M.·2004·International Journal of Systematic and Evolutionary Microbiology

DOI 10.1099/ijs.0.02873-0

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Abstract

The diversity of mucin-degrading bacteria in the human intestine was investigated by combining culture and 16S rRNA-dependent approaches. A dominant bacterium, strain Muc T , was isolated by dilution to extinction of faeces in anaerobic medium containing gastric mucin as the sole carbon and nitrogen source. A pure culture was obtained using the anaerobic soft agar technique. Strain Muc T was a Gram-negative, strictly anaerobic, non-motile, non-spore-forming, oval-shaped bacterium that could grow singly and in pairs. When grown on mucin medium, cells produced a capsule and were found to aggregate. Strain Muc T could grow on a limited number of sugars, including N -acetylglucosamine, N -acetylgalactosamine and glucose, but only when a protein source was provided and with a lower growth rate and final density than on mucin. The G+C content of DNA from strain Muc T was 47·6 mol%. 16S rRNA gene sequence analysis revealed that the isolate was part of the division Verrucomicrobia . The closest described relative of strain Muc T was Verrucomicrobium spinosum (92 % sequence similarity). Remarkably, the 16S rRNA gene sequence of strain Muc T showed 99 % similarity to three uncultured colonic bacteria. According to the data obtained in this work, strain Muc T represents a novel bacterium belonging to a new genus in subdivision 1 of the Verrucomicrobia ; the name Akkermansia muciniphila gen. nov., sp. nov. is proposed; the type strain is Muc T (=ATCC BAA-835 T =CIP 107961 T ).

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Authors: Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M.
Affiliations: Wageningen University & Research (NL)
Laboratory of Microbiology, Wageningen University, Hesselink van Suchtelenweg 4, 6703 CT Wageningen, The Netherlands
ORCID: Derrien, Muriel
Vaughan, Elaine E.
Plugge, Caroline M.
Venue: International Journal of Systematic and Evolutionary Microbiology
Publisher: Microbiology Society
Published: 2004-09-01
Volume: 54
Issue: 5
Pages: 1469-1476
ISSN: 1466-5026 (ISSN-L)
1466-5034
DOI: 10.1099/ijs.0.02873-0
OpenAlex: W2134241692
Cited by: 2,094
References: 37
Citations by year: 2026: 157 · 2025: 190 · 2024: 212 · 2023: 200 · 2022: 230 · 2021: 197 · 2020: 180 · 2019: 160 · 2018: 110 · 2017: 96 · 2016: 103 · 2015: 63 · 2014: 52 · 2013: 36 · 2012: 28
FWCI: 2.47
Type: journal article
Language: en
Open access: green
research.wur.nl
Locations: INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords: Akkermansia muciniphila, novel bacterial genus
MeSH terms: Acetylgalactosamine, Acetylglucosamine, Base Composition, Carbon, Culture Media, DNA, Bacterial, DNA, Ribosomal, Feces, Gastric Mucins, Glucose, Gram-Negative Anaerobic Bacteria, Humans, Intestines, Molecular Sequence Data, Movement, Nitrogen, Phylogeny, RNA, Bacterial, RNA, Ribosomal, 16S, Spores, Bacterial, Bacterial Capsules, Sequence Analysis, DNA, Genes, rRNA

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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