Prostaglandin production during growth of Candida albicans biofilms
Abstract
Both biofilms and planktonic (suspended) cells of Candida albicans synthesized extracellular prostaglandin(s) during growth at 37 degrees C, but biofilm cells secreted significantly more prostaglandin(s) when production was determined on the basis of cell dry weight. Prostaglandin synthesis by both cell types was sensitive to the cyclooxygenase inhibitors aspirin, diclofenac and etodolac. A morphological mutant blocked in two signalling pathways (cph1/cph1 efg1/efg1) produced prostaglandin levels similar to those of the parent strain, but formed yeast-only biofilms. These results suggest that prostaglandin production could be a significant virulence factor in biofilm-associated infections, although its role in C. albicans morphogenesis remains unclear.
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The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis.
“The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis [5]; interestingly, prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development [5].”
From In vitro analysis of flufenamic acid activity against Candida albicans biofilms (2014) · cites this paper as [5]
Prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development.
“The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis [5]; interestingly, prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development [5].”
From In vitro analysis of flufenamic acid activity against Candida albicans biofilms (2014) · cites this paper as [5]
Non-steroidal anti-inflammatory drugs (NSAIDs) have been discovered to possess potent antibacterial activities.
“Furthermore, there has been increasing attention to drugs belonging to different pharmacological classes for possible antimicrobial activity, including a number of non-steroidal anti-inflammatory drugs (NSAIDs), which have been discovered to possess potent antibacterial activities [4,5].”
From In vitro analysis of flufenamic acid activity against Candida albicans biofilms (2014) · cites this paper as [5]
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- Authors
- Alem, M. A., & Douglas, L. J.
- Affiliations
- University of Glasgow (GB)
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 2005-11-01
- Volume
- 54
- Issue
- 11
- Pages
- 1001-1005
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2120434307
- Semantic Scholar
- 2c3a80d3a701073b996ce9eda77338ccae7d8814
- Cited by
- 91
- References
- 19
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 5 · 2012: 8
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, prostaglandin synthesis, biofilm, planktonic cells, cyclooxygenase inhibitors, aspirin, diclofenac, etodolac, morphogenesis, Cph1, EFG1, virulence factors, biofilm-associated infections
- MeSH terms
- Aspirin, Candida albicans, Diclofenac, Microscopy, Electron, Scanning, Morphogenesis, Prostaglandins, Signal Transduction, Cyclooxygenase Inhibitors, Etodolac, Biofilms, Virulence Factors
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