Cited by 99Antifungal resistance and susceptibilityBacterial biofilms and quorum sensingFungal and yeast genetics research

Prostaglandin production during growth of Candida albicans biofilms

Alem, Mohammed AS, Douglas, L Julia·2005·Journal of Medical Microbiology

Abstract

Both biofilms and planktonic (suspended) cells of Candida albicans synthesized extracellular prostaglandin(s) during growth at 37 degrees C, but biofilm cells secreted significantly more prostaglandin(s) when production was determined on the basis of cell dry weight. Prostaglandin synthesis by both cell types was sensitive to the cyclooxygenase inhibitors aspirin, diclofenac and etodolac. A morphological mutant blocked in two signalling pathways (cph1/cph1 efg1/efg1) produced prostaglandin levels similar to those of the parent strain, but formed yeast-only biofilms. These results suggest that prostaglandin production could be a significant virulence factor in biofilm-associated infections, although its role in C. albicans morphogenesis remains unclear.

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Crossref · 10.1099/jmm.0.46172-0

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19 of 19 references verified0 citation errors · 0 not checkable

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  • The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis.

    “The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis [5]; interestingly, prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development [5].”
  • Prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development.

    “The antimicrobial activity of NSAIDs is thought to be due to inhibition of prostaglandin biosynthesis [5]; interestingly, prostaglandin biosynthesis contributes to fungal hyphal formation and biofilm development [5].”
  • Non-steroidal anti-inflammatory drugs (NSAIDs) have been discovered to possess potent antibacterial activities.

    “Furthermore, there has been increasing attention to drugs belonging to different pharmacological classes for possible antimicrobial activity, including a number of non-steroidal anti-inflammatory drugs (NSAIDs), which have been discovered to possess potent antibacterial activities [4,5].”

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Authors
Alem, M. A., & Douglas, L. J.
Affiliations
University of Glasgow (GB)
Venue
Journal of Medical Microbiology
Published
2005-11-01
Volume
54
Issue
11
Pages
1001-1005
ISSN
  • 0022-2615 (ISSN-L)
  • 1473-5644
OpenAlex
W2120434307
Cited by
91
References
19
Citations by year
2026: 1 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 6 · 2013: 5 · 2012: 8
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medical Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Candida albicans, prostaglandin synthesis, biofilm, planktonic cells, cyclooxygenase inhibitors, aspirin, diclofenac, etodolac, morphogenesis, Cph1, EFG1, virulence factors, biofilm-associated infections
MeSH terms
Aspirin, Candida albicans, Diclofenac, Microscopy, Electron, Scanning, Morphogenesis, Prostaglandins, Signal Transduction, Cyclooxygenase Inhibitors, Etodolac, Biofilms, Virulence Factors

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