Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

Tyrrell, Jean; Callaghan, Máire

doi:10.1099/mic.0.000220

Cited by 56Bacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesIron Metabolism and Disorders

Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

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Tyrrell, Jean, Callaghan, Máire·2016·Microbiology

DOI 10.1099/mic.0.000220PMC PMC4772740

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Abstract

Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition has the potential to unveil new avenues for therapeutic intervention to treat both acute and chronic CF infections. Here, we examine the range of strategies utilized by the primary CF pathogens to acquire iron and discuss the different approaches to targeting iron acquisition systems as an antimicrobial strategy.

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The low pH of the cystic fibrosis lung, in part due to inflammation, may promote the ferrous form of iron.
“In addition, the low pH of the CF lung, in part due to inflammation, may promote the ferrous form (Tate et al., 2002; Tyrrell and Callaghan, 2016).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Tyrrell and Callaghan, 2016
The “IRON AND CF” section says the acidic environment of the CF lung may limit Fe²⁺ oxidation, enhancing ferrous iron levels. It also describes inflammation in the CF lung, but does not say inflammation contributes to its low pH. No page number is available in our copy. (LLM, conf=0.85)
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Authors: Tyrrell, J., & Callaghan, M.
Affiliations: Institute of Technology Tallaght (IE)
Venue: Microbiology
Publisher: Microbiology Society
Published: 2016-02-01
Volume: 162
Issue: 2
Pages: 191-205
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/mic.0.000220
PMC: PMC4772740
OpenAlex: W2232650769
Cited by: 56
References: 207
Citations by year: 2026: 3 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 10 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 5 · 2016: 4 · 2014: 1
FWCI: 0.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow - TU Dublin (Technological University Dublin) (submittedVersion, cc-by-nc-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords: iron acquisition, cystic fibrosis lung, siderophores, siderophore-mediated iron uptake, pathogenic bacteria, fungal pathogens, heme proteins, ferrous iron uptake, antimicrobial strategies, chronic lung infection
MeSH terms: Cystic Fibrosis, Humans, Iron, Lung, Mucociliary Clearance, Pseudomonas aeruginosa, Pseudomonas Infections, Staphylococcal Infections, Staphylococcus aureus, Siderophores, Cystic Fibrosis Transmembrane Conductance Regulator, Iron-Binding Proteins, Microbiota

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Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

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