Die another way – non-apoptotic mechanisms of cell death

Tait, Stephen W. G.; Ichim, Gabriel; Green, Douglas R.

doi:10.1242/jcs.093575

Cited by 366Cell death mechanisms and regulationInflammasome and immune disordersAutophagy in Disease and Therapy

Die another way – non-apoptotic mechanisms of cell death

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Tait, Stephen W. G., Ichim, Gabriel, Green, Douglas R.·2014·Journal of Cell Science

DOI 10.1242/jcs.093575PMC PMC4021468

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Abstract

Regulated, programmed cell death is crucial for all multicellular organisms. Cell death is essential in many processes, including tissue sculpting during embryogenesis, development of the immune system and destruction of damaged cells. The best-studied form of programmed cell death is apoptosis, a process that requires activation of caspase proteases. Recently it has been appreciated that various non-apoptotic forms of cell death also exist, such as necroptosis and pyroptosis. These non-apoptotic cell death modalities can be either triggered independently of apoptosis or are engaged should apoptosis fail to execute. In this Commentary, we discuss several regulated non-apoptotic forms of cell death including necroptosis, autophagic cell death, pyroptosis and caspase-independent cell death. We outline what we know about their mechanism, potential roles in vivo and define outstanding questions. Finally, we review data arguing that the means by which a cell dies actually matters, focusing our discussion on inflammatory aspects of cell death.

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In contrast to highly pro-inflammatory necrotic death modes such as necroptosis and pyroptosis, apoptosis and autophagy generally do not trigger an inflammatory response.
“In contrast to the highly pro-inflammatory necrotic types of cell death, such as necroptosis and pyroptosis, apoptosis and autophagy do not tend to trigger an inflammatory response166.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [166]

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Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity
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“In vivo support of this model comes from the finding that embryonic lethality caused by caspase-8 or FADD loss in vivo can be completely rescued by RIPK3 ablation (Dillon et al., 2012; Kaiser et al., 2011; Oberst et al., 2011).”
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Interdigital cell death can occur through a necrotic and caspase-independent pathway
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The Release of Cytochrome c from Mitochondria during Apoptosis of NGF-deprived Sympathetic Neurons Is a Reversible Event
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Widespread Mitochondrial Depletion via Mitophagy Does Not Compromise Necroptosis
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The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation
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Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
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Evidence of a Novel Event during Neuronal Death
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Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling
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NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
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Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
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Macrophage Activation Redirects Yersinia-Infected Host Cell Death from Apoptosis to Caspase-1-Dependent Pyroptosis
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Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
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Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
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Necrotic Death Pathway in FAS Receptor Signaling
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Means to an end: apoptosis and other cell death mechanisms
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Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma
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Macroautophagy Is Required for Multicellular Development of the Social Amoeba Dictyostelium discoideum
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Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
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A Perspective on Mammalian Caspases as Positive and Negative Regulators of Inflammation
Martin, S. J., Henry, C. M., & Cullen, S. P. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.026 · Cited by 206 · see citing works
Resistance to Caspase-Independent Cell Death Requires Persistence of Intact Mitochondria
Tait, S. W. G., Parsons, M. J., Llambi, F., Bouchier‐Hayes, L., Connell, S., Muñoz‐Pinedo, C., & Green, D. R. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.014 · Cited by 204 · see citing works
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Adult Apaf-1-Deficient Mice Exhibit Male Infertility
Honarpour, N., Du, C., Richardson, J. A., Hammer, R. E., Wang, X., & Herz, J. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9585 · Cited by 203 · see citing works
Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules
Luo, S., Garcı́a-Arencibia, M., Zhao, R., Puri, C., Toh, P. P. C., Sadiq, O., & Rubinsztein, D. C. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.040 · Cited by 203 · see citing works
Necroptosis in Immunity and Ischemia-Reperfusion Injury
Linkermann, A., Hackl, M. J., Kunzendorf, U., Walczak, H., Krautwald, S., & Jevnikar, A. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12448 · Cited by 188 · see citing works
Inflammasomes: far beyond inflammation
Henao‐Mejia, J., Elinav, E., Strowig, T., & Flavell, R. A. (2012) · Nature Immunology · doi:10.1038/ni.2257 · Cited by 185 · see citing works
Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
Ciechomska, I. A., Goemans, G. C., Skepper, J. N., & Tolkovsky, A. M. (2009) · Oncogene · doi:10.1038/onc.2009.60 · Cited by 180 · see citing works
RIPK-Dependent Necrosis and Its Regulation by Caspases: A Mystery in Five Acts
Green, D. R., Oberst, A., Dillon, C. P., Weinlich, R., & Salvesen, G. S. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.003 · Cited by 169 · see citing works
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Autophagy in Protein and Organelle TurnoverPreprint
Mizushima, N. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.011023 · Cited by 165 · see citing works
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
Weinlich, R., Oberst, A., Dillon, C. P., Janke, L. J., Milasta, S., Lukens, J. R., Rodriguez, D. A., Gurung, P., Savage, C., Kanneganti, T. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.045 · Cited by 157 · see citing works
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It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival
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Autophagy Suppresses RIP Kinase-Dependent Necrosis Enabling Survival to mTOR Inhibition
Bray, K., Mathew, R., Lau, A., Kamphorst, J. J., Fan, J., Chen, J., Chen, H.-Y., Ghavami, A., Stein, M. N., DiPaola, R. S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041831 · Cited by 155 · see citing works
Programmed Necrosis
Galluzzi, L., Berghe, T. V., Vanlangenakker, N., Büttner, S., Eisenberg, T., Vandenabeele, P., Madeo, F., & Kroemer, G. (2011) · International review of cytology · doi:10.1016/b978-0-12-386039-2.00001-8 · Cited by 150 · see citing works
TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
Moujalled, D., Cook, W. D., Okamoto, T., Murphy, J. M., Lawlor, K. E., Vince, J. E., & Vaux, D. L. (2013) · Cell Death and Disease · doi:10.1038/cddis.2012.201 · Cited by 150 · see citing works
Antigen-mediated T cell expansion regulated by parallel pathways of death
Ch’en, I. L., Beisner, D. R., Degterev, A., Lynch, C., Yuan, J., Hoffmann, A., & Hedrick, S. Μ. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808043105 · Cited by 140 · see citing works
Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation.
Rébé, C., Cathelin, S., Launay, S., Filomenko, R., Prévotat, L., L'ollivier, C., Gyan, E., Micheau, O., Grant, S., Dubart-Kupperschmitt, A., et al. (2007) · Blood · doi:10.1182/blood-2006-03-011585 · Cited by 138 · see citing works
Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release
Lartigue, L., Kushnareva, Y., Seong, Y., Lin, H. H., Faustin, B., & Newmeyer, D. D. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0649 · Cited by 134 · see citing works
Butylated hydroxyanisole is more than a reactive oxygen species scavenger
Festjens, N., Kalai, M., Smet, J., Meeus, A., Coster, R. V., Saelens, X., & Vandenabeele, P. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401746 · Cited by 105 · see citing works
Local Apoptosis Modulates Early Mammalian Brain Development through the Elimination of Morphogen-Producing Cells
Nonomura, K., Yamaguchi, Y., Hamachi, M., Koike, M., Uchiyama, Y., Nakazato, K., Mochizuki, A., Sakaue-Sawano, A., Miyawaki, A., Yoshida, H., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.11.015 · Cited by 103 · see citing works
Switch from Caspase-dependent to Caspase-independent Death during Heart Development
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Autophagy Gene Disruption Reveals a Non-vacuolar Cell Death Pathway in Dictyostelium
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Apoptotic and Nonapoptotic Caspase Functions in Animal DevelopmentPreprint
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cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
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Autophagy functions in programmed cell death
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Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons
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Apoptosome-deficient Cells Lose Cytochromecthrough Proteasomal Degradation but Survive by Autophagy-dependent Glycolysis
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Autophagy activity contributes to programmed cell death inCaenorhabditis elegans
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Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors
Goemans, C. G., Boya, P., Skirrow, C. J., & Tolkovsky, A. M. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402290 · Cited by 26 · see citing works

Flagged first, then by citations

4 of the 130 references couldn’t be matched to a known paper.

Sorted by citations

Targeting apoptosis in cancer therapy
Carneiro, B. A., & El‐Deiry, W. S. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0341-y · Cited by 2,594 · see citing works
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works
“Taken together with the notion that the absence of either Ripk3, Casp8 or Fadd fails to rescue Ripk1 / mice from neonatal lethality,(180,185) these results pointed to the existence of a switch mechanism that regulates cell fate upon TNFR1 ligation.(204,205) Intriguingly, such switch may not operate in all cell types,…”
BackgroundSelf-citation
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Rongvaux, A., Jackson, R., Harman, C. C. D., Li, T., West, A. P., de Zoete, M. R., Wu, Y., Yordy, B., Lakhani, S. A., Kuan, C.-Y., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.037 · Cited by 847 · see citing works
“2008; Callus and Vaux, 2007; Tait et al., 2014).”
BackgroundInfluential
Mitochondrial apoptosis: killing cancer using the enemy within
Lopez, J., & Tait, S. W. G. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.85 · Cited by 792 · see citing works
“Importantly, MOMP often leads to cell death irrespective of caspase activity (Tait et al, 2014).”
BackgroundSelf-citation
HSPB1 as a novel regulator of ferroptotic cancer cell death
Sun, X., Ou, Z., Xie, M., Kang, R., Fan, Y., Niu, X., Wang, H., Cao, L., & Tang, D. (2015) · Oncogene · doi:10.1038/onc.2015.32 · Cited by 666 · see citing works
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis
Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899238 · Cited by 551 · see citing works
Self-citation
Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
Ichim, G., Lopez, J., Ahmed, S. U., Muthalagu, N., Giampazolias, E., Delgado, M. E., Haller, M., Riley, J. S., Mason, S. M., Athineos, D., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.01.018 · Cited by 479 · see citing works
“However, even in the absence of caspase activity, cells typically die onceMOMP has occurred, most likely due to progressive mitochondrial dysfunction (Lartigue et al., 2009; Tait et al., 2014).”
Self-citation
A fate worse than death: apoptosis as an oncogenic process
Ichim, G., & Tait, S. W. G. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.58 · Cited by 451 · see citing works
Self-citation
The role of neutrophils and NETosis in autoimmune and renal diseases
Gupta, S., & Kaplan, M. J. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.71 · Cited by 433 · see citing works
JNK-signaling: A multiplexing hub in programmed cell death
Dhanasekaran, D. N., & Reddy, E. P. (2017) · Genes & Cancer · doi:10.18632/genesandcancer.155 · Cited by 358 · see citing works
“In contrast to necroptosis, pyroptosis is a caspase-dependent programmed cell death pathway involving caspase 1 and/ or caspase 5 [25, 30].”
BackgroundInfluential
Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
Gali‐Muhtasib, H. U., Hmadi, R., Kareh, M., Tohmé, R., & Darwiche, N. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1169-2 · Cited by 293 · see citing works
Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)
Rathore, R., McCallum, J. E., Varghese, E., Florea, A.-M., & Büsselberg, D. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1375-1 · Cited by 278 · see citing works
“However, the mechanisms governing the initiation of necroptosis mediated cell death are so far unexplored in vivo and the repercussions of its potential pro-inflammatory nature have not been fully elucidated [34, 35].”
Background
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection
Wang, Y., Ning, X., Gao, P., Wu, S., Sha, M., Lv, M., Zhou, X., Gao, J., Fang, R., Meng, G., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.011 · Cited by 275 · see citing works
“Caspase-dependent apoptosis is unique in its capacity to induce a noninflammatory type of cell death (Tait et al., 2014).”
Background
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming
Adeshakin, F. O., Adeshakin, A. O., Afolabi, L. O., Yan, D., Zhang, G., & Wan, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626577 · Cited by 271 · see citing works
“Furthermore, non-apoptotic cell death includes entosis, methuosis, paraptosis, mitotopsis, parthanatos, ferroptosis, pyroptosis, netosis, necrosis, and autophagic cell death as mentioned in the previous studies (9, 10).”
Background
Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency
Giampazolias, E., Zunino, B., Dhayade, S., Bock, F., Cloix, C., Cao, K., Roca, A., Lopez, J., Ichim, G., Proïcs, E., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3596 · Cited by 258 · see citing works
Self-citation
Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts
Averbeck, D., & Rodriguez‐Lafrasse, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011047 · Cited by 242 · see citing works
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
Antonopoulos, C. H., Russo, H. M., Sanadi, C. E. E., Martin, B. N., Li, X., Kaiser, W. J., Mocarski, E. S., & Dubyak, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.652321 · Cited by 225 · see citing works
“Given its ubiquitous expression, caspase-8 contributes to the apoptosis or necroptosis of myeloid leukocytes in diverse models of microbial infection or pro-inflammatory stress (67, 68).”
Background
Mechanisms of Action and Cell Death Associated with Clostridium perfringens Toxins
Navarro, M. A., McClane, B. A., & Uzal, F. A. (2018) · Toxins · doi:10.3390/toxins10050212 · Cited by 225 · see citing works
The Mitochondrion as an Emerging Therapeutic Target in Cancer
Roth, K. G., Mambetsariev, I., Kulkarni, P., & Salgia, R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.06.009 · Cited by 216 · see citing works
Airborne Particulate Matter
Thompson, J. E. (2018) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001277 · Cited by 217 · see citing works
“Several mechanisms of cellular death have been identified that include apoptosis, necroptosis, pyroptosis, necrosis, and autophagic cell death.(239) Understanding the cell-death mechanism is important to design intervention strategies to ameliorate the detrimental effects of PM on human health.”
Background
Paraptosis in the anti-cancer arsenal of natural products
Lee, D., Kim, I. Y., Saha, S., & Choi, K. S. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.01.003 · Cited by 215 · see citing works
Pyroptosis Plays a Role in Osteoarthritis
An, S., Hu, H., Li, Y., & Hu, Y. (2020) · Aging and Disease · doi:10.14336/ad.2019.1127 · Cited by 206 · see citing works
“Cell death is also a characteristic of abnormal pathological responses to harmful stimuli, such as physical damage and pathogens [1].”
Background
Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits
Jung, S., Choe, S., Woo, H., Jeong, H., An, H.-K., Moon, H., Ryu, H. Y., Yeo, B. K., Lee, Y. W., Choi, H., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1630222 · Cited by 183 · see citing works
“Recent progress in the field of cell death indicates the importance of the modes of programmed cell death (PCD) other than apoptosis, such as autophagic cell death (ACD) or necroptosis in human physiology and diseases [3].”
Background
Roles of neutrophil granule proteins in orchestrating inflammation and immunity
Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 184 · see citing works
Recent insights into cell death and autophagy
Fitzwalter, B. E., & Thorburn, A. M. (2015) · FEBS Journal · doi:10.1111/febs.13515 · Cited by 171 · see citing works
Bacterial Pathogens versus Autophagy: Implications for Therapeutic Interventions
Kimmey, J. M., & Stallings, C. L. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.10.008 · Cited by 163 · see citing works
“Themechanism bywhich an infected cell dies can have amajor impact on immune responses because DAMPs released from dying cells will trigger inflammation [137].”
Background
Cell Death in the Developing Brain after Hypoxia-Ischemia
Thornton, C., Leaw, B., Mallard, C. E., Nair, S., Jinnai, M., & Hagberg, H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00248 · Cited by 163 · see citing works
Apoptosis, Necrosis, and Necroptosis in the Gut and IntestinalHomeostasis
Negroni, A., Cucchiara, S., & Stronati, L. (2015) · Mediators of Inflammation · doi:10.1155/2015/250762 · Cited by 163 · see citing works
“Apoptosis has long been considered the only form of regulated cell death, while the existence of additional forms of controlled cell death is now well established [24, 25].”
Background
Targeting Ferroptosis against Ischemia/Reperfusion Cardiac Injury
Lillo‐Moya, J., Rojas-Solé, C., Muñoz-Salamanca, D., Panieri, E., Saso, L., & Rodrigo, R. (2021) · Antioxidants · doi:10.3390/antiox10050667 · Cited by 161 · see citing works
“This cell death pathway, unlike other cell death pathways such as apoptosis, does not present a silent inflammatory response [91].”
Background
Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells
Saveljeva, S., Laughlin, S. L. M., Vandenabeele, P., Samali, A., & Bertrand, M. J. M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.548 · Cited by 149 · see citing works
“the only form of regulated cell death, but existence of additional forms of controlled cell death is nowwell established.(32,33) These can be triggered independently of apoptosis induction or as back-up safety mechanisms in situations where the apoptotic machinery does not operate properly, such as a result of genetic…”
Background
Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma
Zielinska, E., Zauszkiewicz–Pawlak, A., Wójcik, M., & Inkielewicz‐Stępniak, I. (2017) · Oncotarget · doi:10.18632/oncotarget.22563 · Cited by 143 · see citing works
Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium
Ros, U., Peña‐Blanco, A., Hänggi, K., Kunzendorf, U., Krautwald, S., Wong, W. W.-L., & García‐Sáez, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.024 · Cited by 134 · see citing works
“Experimentally, it is induced by a combination of TNF-a treatment with molecules that sensitize its activity such as second mitochondria-derived activator of caspases (Smac) mimetics, inhibitors of RNA, or protein synthesis and caspase inhibitors (Tait et al., 2014; Wallach et al., 2016).”
Implication of ferroptosis in aging
Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 133 · see citing works
“Besides these modes of cell death, non-apoptotic mechanisms also exist [22] and that is ferroptosis.”
Background
Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury
Sancho-Martínez, S. M., López-Novoa, J. M., & López-Hernández, F. J. (2015) · Clinical Kidney Journal · doi:10.1093/ckj/sfv069 · Cited by 130 · see citing works
Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
Koklesová, L., Líšková, A., Samec, M., Buhrmann, C., Samuel, S. M., Varghese, E., Ashrafizadeh, M., Najafi, M., Shakibaei, M., Büsselberg, D., et al. (2020) · Cancers · doi:10.3390/cancers12092425 · Cited by 124 · see citing works
“Programmed cell death (PCD) represents an important concept, which is defined as a genetically regulated cascade leading to controlled cell removal.”
BackgroundInfluential
Mitochondria and Inflammation: Cell Death Heats Up
Vringer, E., & Tait, S. W. G. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00100 · Cited by 123 · see citing works
“Nevertheless, cells usually die irrespective of caspase activation upon MOMP, demarcating it as a point of no return (Tait et al., 2014).”
BackgroundSelf-citation
Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages
He, B., Shi, Y., Liang, Y., Yang, A., Fan, Z., Yuan, L., Zou, X., Chang, X. Y., Zhang, H., Wang, X., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04700-z · Cited by 122 · see citing works
Oxidants, Antioxidants and Thiol Redox Switches in the Control of Regulated Cell Death Pathways
Benhar, M. (2020) · Antioxidants · doi:10.3390/antiox9040309 · Cited by 118 · see citing works
“In the last two decades, additional forms of RCD have been discovered and characterized [15,16].”
BackgroundInfluential
PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells
Zhao, J., Dar, H. H., Deng, Y., Croix, C. M. S., Li, Z., Minami, Y., Shrivastava, I. H., Tyurina, Y. Y., Etling, E. B., Rosenbaum, J. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1921618117 · Cited by 120 · see citing works
Pannexin1 as mediator of inflammation and cell death
Yanguas, S. C., Willebrords, J., Johnstone, S. R., Maes, M., Decrock, E., Bock, M. D., Leybaert, L., Cogliati, B., & Vinken, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.006 · Cited by 119 · see citing works
Paraptosis: a unique cell death mode for targeting cancer
Hanson, S., Dharan, A., Jinsha, P. V., Pal, S., Nair, B. G., Kar, R., & Mishra, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1159409 · Cited by 117 · see citing works
“An alternate death pathway is activated in the cell only when its apoptosis machinery is non-functional (Chipuk and Green, 2005; Elmore, 2007; Tait et al., 2014).”
Background
mRNA-encoded, constitutively active STINGV155M is a potent genetic adjuvant of antigen-specific CD8+ T cell response
Tse, S., McKinney, K. M., Walker, W., Nguyen, M., Iacovelli, J., Small, C. G., Hopson, K., Zaks, T. Z., & Huang, E. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.03.002 · Cited by 113 · see citing works
“As an alternative to inducing constitutively active innate immune sensor signaling pathways as genetic adjuvants, we also attempted to induce two forms of programmed cell death: necroptosis and pyroptosis.(44) Both mechanisms result in loss of cell membrane integrity and subsequent release of DAMPs such as high mobili…”
Background
Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy
Wei, J., Zhao, Y., Liang, H., Du, W., & Wang, L. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.08.026 · Cited by 106 · see citing works
Cell death at the intestinal epithelial front line
Delgado, M. E., Grabinger, T., & Brunner, T. (2015) · FEBS Journal · doi:10.1111/febs.13575 · Cited by 102 · see citing works
Non-apoptotic cell death in malignant tumor cells and natural compounds
Ye, J., Zhang, R., Wu, F., Zhai, L., Wang, K., Xiao, M., Xie, T., & Sui, X. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.061 · Cited by 102 · see citing works
Ferritinophagy drives uropathogenicEscherichia colipersistence in bladder epithelial cells
Bauckman, K. A., & Mysorekar, I. U. (2016) · Autophagy · doi:10.1080/15548627.2016.1160176 · Cited by 100 · see citing works
“We first considered apoptosis and inflammatory-mediated apoptosis, pyroptosis.(38) To assess apoptosis, we used western blots to Figure 3.”
Method
Role of mitochondria in apoptotic and necroptotic cell death in the developing brain
Thornton, C., & Hagberg, H. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.026 · Cited by 102 · see citing works
“In addition, RIP3 may also play a role in the decision of the cell to follow an apoptotic or necroptotic route although the mechanism is unclear [34,35].”
Background
The innate immune response to allotransplants: mechanisms and therapeutic potentials
Ochando, J., Ordikhani, F., Boros, P., & Jordan, S. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0216-2 · Cited by 102 · see citing works
In Vitro Cell Death Determination for Drug Discovery: A Landscape Review of Real Issues
Méry, B., Guy, J., Vallard, A., Espenel, S., Ardail, D., Rodriguez‐Lafrasse, C., Rancoule, C., & Magné, N. (2017) · Journal of Cell Death · doi:10.1177/1179670717691251 · Cited by 98 · see citing works
Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy
Aishajiang, R., Liu, Z., Wang, T., Zhou, L. Y., & Yu, D. N. (2023) · Molecules · doi:10.3390/molecules28052303 · Cited by 95 · see citing works
Programmed cell death in aortic aneurysm and dissection: A potential therapeutic target
Chakraborty, A., Yang, L., Zhang, C., Li, Y., LeMaire, S. A., & Shen, Y. H. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.09.010 · Cited by 89 · see citing works
“Many other types of non-apoptotic programmed cell death have been characterized, including necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, neutrophil extracellular traps–mediated (NETotic) cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular…”
Background
Chemical warfare agents. Classes and targets
Schwenk, M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.11.040 · Cited by 90 · see citing works
Ferroptosis and Senescence: A Systematic Review
Coradduzza, D., Congiargiu, A., Chen, Z., Zinellu, A., Carru, C., & Medici, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043658 · Cited by 90 · see citing works
“Ferroptosis was first reported in 2012 [1,2], as an iron-dependent mechanism of nonapoptotic cell death [3], which has attracted the researchers’ interest due to its implications in the pathogenesis of various age-related disorders.”
Background
Chlorpyrifos induces NLRP3 inflammasome and pyroptosis/apoptosis via mitochondrial oxidative stress in human keratinocyte HaCaT cells
Jang, Y., Lee, A. Y., Jeong, S., Park, K.-H., Paik, M.-K., Cho, N.-J., Kim, J., & Cho, M. (2015) · Toxicology · doi:10.1016/j.tox.2015.09.006 · Cited by 88 · see citing works
Bacteriocyte cell death in the pea aphid/ Buchnera symbiotic system
Simonet, P., Gaget, K., Balmand, S., Lopes, M. R., Parisot, N., Buhler, K., Duport, G., Vulsteke, V., Febvay, G., Heddi, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720237115 · Cited by 84 · see citing works
Repurposing of antipsychotic trifluoperazine for treating brain metastasis, lung metastasis and bone metastasis of melanoma by disrupting autophagy flux
Xia, Y., Xu, F., Xiong, M., Yang, H., Lin, W., Xie, Y., Xi, H., Xue, Q., Ye, T., & Yu, L. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105295 · Cited by 83 · see citing works
Autophagy in renal diseases
Rechter, S. D., Decuypere, J.-P., Ivanova, E., van den Heuvel, L. P., SMEDT, H. D., Levtchenko, E. N., & Mekahli, D. (2015) · Pediatric Nephrology · doi:10.1007/s00467-015-3134-2 · Cited by 79 · see citing works
“Unconjugated Atg12 can induce apoptosis by inhibiting Bcl-2 [26].”
Background
The hidden side of SERPINB1/Leukocyte Elastase Inhibitor
Torriglia, A., Martin, E., & Jaadane, I. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.07.010 · Cited by 80 · see citing works
The DNA-damage response and nuclear events as regulators of nonapoptotic forms of cell death
Prokhorova, E. A., Egorshina, A. Y., Zhivotovsky, B., & Kopeina, G. S. (2019) · Oncogene · doi:10.1038/s41388-019-0980-6 · Cited by 77 · see citing works
SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death
Guo, C., Wilkinson, K. A., Evans, A. J., Rubin, P. P., & Henley, J. M. (2017) · Scientific Reports · doi:10.1038/srep43811 · Cited by 77 · see citing works
Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
Novgorodov, S. A., Voltin, J. R., Gooz, M. A., Li, L., Lemasters, J. J., & Gudz, T. I. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m080374 · Cited by 77 · see citing works
“The initiation of necroptosis leads to activation of RIPK1 and RIPK3 and formation of a multi-protein complex necrosome, which includes a key downstream target of RIPK3, a MLKL pseudokinase.”
BackgroundInfluential
Population Dynamics in Cell Death: Mechanisms of Propagation
Riegman, M., Bradbury, M. S., & Overholtzer, M. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.07.008 · Cited by 77 · see citing works
“It was once thought that apoptosis, a form of cell suicide, was the only regulated form of cell death, but recent findings have uncovered numerous additional regulated death mechanisms, including several forms of necrosis [3], a program called entosis [5], and others.”
BackgroundInfluential
Post-Cardiac Arrest: Mechanisms, Management, and Future Perspectives
Lazzarin, T., Tonon, C., Martins, D., Fávero, E. L., Baumgratz, T. D., Pereira, F. L., Pinheiro, V. R., Ballarin, R. S., Queiroz, D., Azevedo, P., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010259 · Cited by 69 · see citing works
“Each of these mechanisms is activated by distinct signaling pathways, culminating in different modes of cell death and different consequences for the organism [35].”
Background
Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells
Lee, W., Probst, S., Santoyo-Sánchez, M. P., Al-Hamdani, W., Diebels, I., von Sivers, J.-K., Kerek, E. M., Prenner, E. J., & Thévenod, F. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-1942-9 · Cited by 76 · see citing works
“Meanwhile, a plethora of additional apoptotic and non-apoptotic death modes have been characterized (Fuchs and Steller 2015; Tait et al. 2014).”
Background
Exploring the Cytotoxicity, Uptake, Cellular Response, and Proteomics of Mono- and Dinuclear DNA Light-Switch Complexes
Jarman, P. J., Noakes, F. F., Fairbanks, S. D., Smitten, K. L., Griffiths, I. K., Saeed, H. K., Thomas, J. A., & Smythe, C. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b09999 · Cited by 73 · see citing works
Natural Products as Inducers of Non-Canonical Cell Death: A Weapon against Cancer
Greco, G., Catanzaro, E., & Fimognari, C. (2021) · Cancers · doi:10.3390/cancers13020304 · Cited by 69 · see citing works
Mapping out p38 MAPK
Bonney, E. A. (2017) · American Journal of Reproductive Immunology · doi:10.1111/aji.12652 · Cited by 67 · see citing works
Synthesis of Tragia involucrata mediated platinum nanoparticles for comprehensive therapeutic applications: Antioxidant, antibacterial and mitochondria-associated apoptosis in HeLa cells
Selvi, A. M., Palanisamy, S., Jeyanthi, S., Vinosha, M., Mohandoss, S., Tabarsa, M., You, S., Ethiraj, K., & Prabhu, N. M. (2020) · Process Biochemistry · doi:10.1016/j.procbio.2020.07.008 · Cited by 66 · see citing works
Unconjugated bilirubin induces pyroptosis in cultured rat cortical astrocytes
Feng, J., Li, M., Wei, Q., Sheng-jun, L., Song, S., & Hua, Z. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1064-1 · Cited by 65 · see citing works
“and cell survival in nervous system pathologies [21, 23, 37].”
Involvement of planned cell death of necroptosis in cancer treatment by nanomaterials: Recent advances and future perspectives
Sharifi, M., Hosseinali, S. H., Saboury, A. A., Szegezdi, É., & Falahati, M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.007 · Cited by 62 · see citing works
Green Synthesis of Platinum Nanoparticles for Biomedical Applications
Михайлова, Е. О. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13040260 · Cited by 63 · see citing works
Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease
Atlante, A., Amadoro, G., Bobba, A., & Latina, V. (2020) · Cells · doi:10.3390/cells9112347 · Cited by 65 · see citing works
Mito-priming as a method to engineer Bcl-2 addiction
Lopez, J., Bessou, M., Riley, J. S., Giampazolias, E., Todt, F., Rochegüe, T., Oberst, A., Green, D. R., Edlich, F., Ichim, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10538 · Cited by 58 · see citing works
“5b,c) and (2) BIM, which displays an anti-apoptotic Bcl-2 binding profile similar to tBID and PUMA5,21,29, failed to display any selectivity for BAK or BAX.”
BackgroundSelf-citation
Nanostructured toxins for the selective destruction of drug-resistant human CXCR4+ colorectal cancer stem cells
Serna, N., Álamo, P., Ramesh, P., Vinokurova, D., Sánchez‐García, L., Unzueta, U., Gallardo, A., Céspedes, M. V., Vázquez, E., Villaverde, A., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.01.019 · Cited by 62 · see citing works
Antioxidant, anticancer activities and mechanistic studies of the flavone glycoside diosmin and its oxidovanadium(IV) complex. Interactions with bovine serum albumin
Naso, L. G., Martínez, V. R., Lezama, L. M., Salado, C., Valcárcel, M., Ferrer, E. G., & Williams, P. A. M. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.06.053 · Cited by 60 · see citing works
Depletion of mitochondria in mammalian cells through enforced mitophagy
Correia‐Melo, C., Ichim, G., Tait, S. W. G., & Passos, J. F. (2016) · Nature Protocols · doi:10.1038/nprot.2016.159 · Cited by 61 · see citing works
Self-citation
Anticancer Agents Targeted to Sirtuins
Kozako, T., Suzuki, T., Yoshimitsu, M., Arima, N., Honda, S., & Soeda, S. (2014) · Molecules · doi:10.3390/molecules191220295 · Cited by 59 · see citing works
“For the maintenance of homeostasis, regulated cell death plays a key role in a variety of biological processes including tissue sculpting during embryogenesis, development of immunity, and destruction of damaged cells and tumors [53].”
Background
DED or alive: assembly and regulation of the death effector domain complexes
Riley, J. S., Malik, A., Holohan, C., & Longley, D. B. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.213 · Cited by 57 · see citing works
“cell death have emerged, including necroptosis, pyroptosis and ferroptosis, which have been comprehensively reviewed elsewhere.(2,3) Here, we focus on those mechanisms of cell”
Background
Mitochondria orchestrate macrophage effector functions in atherosclerosis
Dumont, A., Lee, M., Barouillet, T., Murphy, A. J., & Yvan‐Charvet, L. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100922 · Cited by 59 · see citing works
Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan
Zhan, Y., Chow, K. V., Soo, P., Xu, Z., Brady, J. L., Lawlor, K. E., Masters, S. L., O’Keeffe, M. A., Shortman, K., Zhang, J., et al. (2016) · Scientific Reports · doi:10.1038/srep25060 · Cited by 56 · see citing works
Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival
Zhou, Z., & Sun, L. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00076 · Cited by 56 · see citing works
Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells
Wu, C., Hong, C., Klauck, S. M., Lin, Y., & Efferth, T. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.10.020 · Cited by 55 · see citing works
Anticancer metallohelices: nanomolar potency and high selectivity
Kaner, R. A., Allison, S. J., Faulkner, A. D., Phillips, R. M., Roper, D. I., Shepherd, S. L., Simpson, D. H., Waterfield, N. R., & Scott, P. (2015) · Chemical Science · doi:10.1039/c5sc03677a · Cited by 55 · see citing works
Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma
Stefanović, M., Tutusaus, A., Martínez-Nieto, G., Bárcena, C., de Gregorio, E., Moutinho, C., Barbero‐Camps, E., Villanueva, A., Colell, A., Marı́, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6982 · Cited by 55 · see citing works
“Release of mitochondrial intermembrane proteins such as cytochrome c induces a rapid loss of activity in respiratory complexes jeopardizing mitochondrial functionality, and leading to bioenergetic crisis and cell death [34].”
6-Shogaol induces caspase-independent paraptosis in cancer cells via proteasomal inhibition
Nedungadi, D., Binoy, A., Nanjan, P., Pal, S., Nair, B. G., & Mishra, N. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.02.018 · Cited by 55 · see citing works
The Complex Mechanisms by Which Neurons Die Following DNA Damage in Neurodegenerative Diseases
Shadfar, S., Brocardo, M. G., & Atkin, J. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052484 · Cited by 54 · see citing works
“Furthermore, depending on the stimulus and cellular context, in some circumstances, autophagy may antagonize or delay apoptosis, or if these two processes act exclusively, they serve as reciprocal backup mechanisms [87].”
Background
The Typhoid Toxin Produced by the Nontyphoidal Salmonella enterica Serotype Javiana Is Required for Induction of a DNA Damage Response In Vitro and Systemic Spread In Vivo
Miller, R. A., Betteken, M. I., Guo, X., Altier, C., Duhamel, G. E., & Wiedmann, M. (2018) · mBio · doi:10.1128/mbio.00467-18 · Cited by 54 · see citing works
“Because other, nonapoptotic cell death pathways exist (32), we also quantified the number of PI-positive cells (used as a live/dead stain).”
Caspase selective reagents for diagnosing apoptotic mechanisms
Poręba, M., Groborz, K. M., Navarro, M., Snipas, S. J., Drąg, M., & Salvesen, G. S. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0110-y · Cited by 54 · see citing works
Lytic Cell Death Mechanisms in Human Respiratory Syncytial Virus-Infected Macrophages: Roles of Pyroptosis and Necroptosis
Bedient, L., Pokharel, S. M., Chiok, K. L., Mohanty, I. P., Beach, S. S., Miura, T. A., & Bose, S. (2020) · Viruses · doi:10.3390/v12090932 · Cited by 54 · see citing works
“Lytic cell death is an inflammatory cell death caused primarily by two cellular mechanisms: pyroptosis and necroptosis [12,13,18].”
Background
The Janus Face of Death Receptor Signaling during Tumor Immunoediting
Reilly, E. O., Tirincsi, A., Logue, S. E., & Szegezdi, É. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00446 · Cited by 53 · see citing works
“In the absence of caspase-8 activation, the cell can either undergo death via necroptosis (134) or induce NF-κB activity and survival signaling (135) with the outcome dependent on the ubiquitination status of RIPK1 (Figure 2D).”
Background
Caspase-8 Regulates Endoplasmic Reticulum Stress-Induced Necroptosis Independent of the Apoptosis Pathway in Auditory Cells
Kishino, A., Hayashi, K., Maeda, M., Jike, T., Hidai, C., Nomura, Y., & Oshima, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235896 · Cited by 53 · see citing works
“Recently, it has been appreciated that various types of non-apoptotic cell deaths, like necroptosis, exist [19].”
Background
Salvianolic Acid B Suppresses ER Stress‐Induced NLRP3 Inflammasome and Pyroptosis via the AMPK/FoxO4 and Syndecan‐4/Rac1 Signaling Pathways in Human Endothelial Progenitor Cells
Tang, Y., Wa, Q., Peng, L., Zheng, Y., Chen, J., Chen, X., Zou, X., Shen, H., & Huang, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8332825 · Cited by 52 · see citing works
“Activated caspase-1, meanwhile, can promote caspase-1-dependent pyroptosis [16].”
Induction of Necroptosis in Cancer Stem Cells using a Nickel(II)‐Dithiocarbamate Phenanthroline Complex
Flamme, M., Cressey, P., Lü, C., Bruno, P. M., Eskandari, A., Hemann, M. T., Hogarth, G., & Suntharalingam, K. (2017) · Chemistry - A European Journal · doi:10.1002/chem.201701837 · Cited by 53 · see citing works
Necroptosis in amyotrophic lateral sclerosis and other neurological disorders
Morrice, J. R., Gregory, C. Y., & Shaw, C. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.025 · Cited by 50 · see citing works
NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis
Carneiro, M. B. H., Roma, E. H., Ranson, A. J., Doria, N. A., Debrabant, A., Sacks, D. L., Vieira, L. Q., & Peters, N. C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700899 · Cited by 50 · see citing works
“necroptosis, pyroptosis, or some other caspase-independent form of cell death (67).”
Background
Fibronectin has multifunctional roles in posterior capsular opacification (PCO)
Shihan, M. H., Kanwar, M., Wang, Y., Jackson, E., Faranda, A. P., & Duncan, M. K. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.02.004 · Cited by 50 · see citing works
Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells
Yang, L., Liu, Y., Wang, M., Qian, Y., Dai, X., Zhu, Y., Chen, J., Guo, S., & Hisamitsu, T. (2016) · Oncology Letters · doi:10.3892/ol.2016.5213 · Cited by 49 · see citing works
The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS
Cui, Y., Liu, Y., & Zhang, F. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.12.144 · Cited by 48 · see citing works
Glutathione peroxidase 7 suppresses cancer cell growth and is hypermethylated in gastric cancer
Chen, Z., Hu, T., Zhu, S., Mukaisho, K., El-Rifai, W. M., & Peng, D. (2017) · Oncotarget · doi:10.18632/oncotarget.17527 · Cited by 47 · see citing works
“However, there are multiple forms of non-apoptotic cell death [30, 31] that may also contribute to the net outcome and functions of GPX7 in cellular homeostasis.”
Background

Death by design: apoptosis, necrosis and autophagy
Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,364 · see citing works
Editorial: Non-apoptotic cell death mechanisms and their therapeutic significance
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Authors: Tait, S. W. G., Ichim, G., & Green, D. R.
Affiliations: Cancer Research UK Scotland Institute (GB)
St. Jude Children's Research Hospital (US)
ORCID: Tait, Stephen W. G.
Ichim, Gabriel
Green, Douglas R.
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2014-05-15
Volume: 127
Issue: 10
Pages: 2135-2144
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.093575
PMC: PMC4021468
OpenAlex: W2021358525
Cited by: 366
References: 130
Citations by year: 2026: 11 · 2025: 16 · 2024: 21 · 2023: 14 · 2022: 26 · 2021: 34 · 2020: 41 · 2019: 48 · 2018: 40 · 2017: 43 · 2016: 35 · 2015: 30 · 2014: 5
FWCI: 3.55
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Cell Science (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/K008374/1)
National Institute of General Medical Sciences (R01GM096208)
National Institute of Allergy and Infectious Diseases (R01AI044828)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: non-apoptotic cell death, programmed cell death, necroptosis, pyroptosis, autophagic cell death, caspase-independent cell death, apoptosis, inflammation, immune system development
MeSH terms: Animals, Autophagy, Humans, Cell Death, Apoptosis

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Die another way – non-apoptotic mechanisms of cell death

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