The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia
Open accessAbstract
Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.
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“Protein, amino acid, and peptides supplementation (Table 1) is considered to be effective in increasing muscle anabolism and preventing muscle atrophy during extended periods of immobilization [19].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [19]
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Sarcopenia, frailty and their prevention by exercise
Nascimento, C. M., Ingles, M., Salvador-Pascual, A., Cominetti, M. R., Gomez-Cabrera, M. C., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.035 · Cited by 396
Thorning, T. K., Bertram, H. C., Bonjour, J., de Groot, C. P. G. M., Dupont, D., Feeney, E. L., Ipsen, R., Lecerf, J. M., Mackie, A. R., McKinley, M. C., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.151548 · Cited by 380
Metadata
- Authors
- Dardevet, D., Rémond, D., Peyron, M.-A., Papet, I., Savary-Auzeloux, I., & Mosoni, L.
- Affiliations
- Université Clermont Auvergne (FR)
- Clermont Université and Unité de Nutrition Humaine, Université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France
- Corresponding author
- Dardevet, Dominique
- Venue
- The Scientific World JOURNAL
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 1537-744X (ISSN-L)
- PMC
- PMC3541599
- OpenAlex
- W2063299372
- Cited by
- 153
- References
- 38
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 19 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 8 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, muscle atrophy, muscle protein anabolism, anabolic resistance, protein nutrition, amino acids, leucine, muscle mass loss, aging, nutritional strategies
- MeSH terms
- Humans, Muscle, Skeletal, Sarcopenia
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