Cited by 153Muscle metabolism and nutritionNutrition and Health in AgingMuscle Physiology and Disorders

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Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia

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Dardevet, Dominique, Rémond, Didier, Peyron, Marie-Agnès, Papet, Isabelle, Savary-Auzeloux, Isabelle, Mosoni, Laurent·2012·The Scientific World JOURNAL

DOI 10.1100/2012/269531PMC PMC3541599

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Abstract

Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.

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Authors: Dardevet, D., Rémond, D., Peyron, M.-A., Papet, I., Savary-Auzeloux, I., & Mosoni, L.
Affiliations: Université Clermont Auvergne (FR)
Clermont Université and Unité de Nutrition Humaine, Université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France
Corresponding author: Dardevet, Dominique
ORCID: Dardevet, Dominique
Rémond, Didier
Peyron, Marie-Agnès
Papet, Isabelle
Mosoni, Laurent
Venue: The Scientific World JOURNAL
Publisher: Hindawi Limited
Published: 2012
Volume: 2012
Pages: 1-6
ISSN: 1537-744X (ISSN-L)
DOI: 10.1100/2012/269531
PMC: PMC3541599
OpenAlex: W2063299372
Cited by: 153
References: 38
Citations by year: 2026: 6 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 19 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 8 · 2012: 1
FWCI: 1.03
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: The Scientific World JOURNAL (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords: sarcopenia, muscle atrophy, muscle protein anabolism, anabolic resistance, protein nutrition, amino acids, leucine, muscle mass loss, aging, nutritional strategies
MeSH terms: Humans, Muscle, Skeletal, Sarcopenia

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Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia

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