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Rational Exploration of Fold Atlas for Human Solute Carrier Proteins
Open accessPreprint — published as 10.1016/j.str.2022.05.015 · Paper page
Abstract
Solute carrier (SLC) superfamily is the largest group responsible for transmembrane transport of substances in human cells. It includes more than 400 members which are organized into 65 families according to their physiological function and sequence similarity. Different families of solute transporters can adopt the same or different folds that determine the working mechanism and reflect the evolutionary relationship between SLC members. Analysis of structural data in literatures shows that there are 13 different folds in the solute carrier superfamily covering 40 families and 343 members. To further study their working mechanism, we systematically explored the SLC superfamily to look for more folds. Based on our results, at least three new folds were found for SLC superfamily, and one was experimentally verified in the SLC44 family. Our work has laid a foundation and provided important insights for the systematic and comprehensive study on the structure and function of solute carriers.
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Research works printed but not linked: 2
- 10.1126/science.abj8754 · DOI · Paper page
- 10.1101/2020.10.12.336859 · DOI
Metadata
- Authors
- Xie, T., Chi, X., Huang, B., Ye, F., Zhou, Q., & Huang, J.
- Affiliations
- Westlake University (CN)
- Corresponding author
- Zhou, Qiang
- Huang, Jing
- ORCID
- Huang, Jing
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2021-08-22
- OpenAlex
- W3195152961
- Cited by
- 0
- References
- 40
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nd
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- Funders
- Westlake University
- National Natural Science Foundation of China (LR19B030001, 32171247, 31971123, 21803057, 32022037)
- Natural Science Foundation of Zhejiang Province (LR19B030001)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- protein folding, transmembrane transporters, protein structure, protein evolution
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