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PreprintCited by 178Artificial Intelligence in Healthcare and EducationInnovations in Medical EducationArtificial Intelligence in Education

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How Does ChatGPT Perform on the Medical Licensing Exams? The Implications of Large Language Models for Medical Education and Knowledge Assessment

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Gilson, Aidan, Safranek, Conrad, Huang, Thomas, Socrates, Vimig, Chi, Ling, Taylor, R. Andrew, Chartash, David·2022·medRxiv
DOI 10.1101/2022.12.23.22283901
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Abstract

Background: ChatGPT is a 175 billion parameter natural language processing model which can generate conversation style responses to user input. Objective: To evaluate the performance of ChatGPT on questions within the scope of United States Medical Licensing Examination (USMLE) Step 1 and Step 2 exams, as well as analyze responses for user interpretability. Methods: We used two novel sets of multiple choice questions to evaluate ChatGPT’s performance, each with questions pertaining to Step 1 and Step 2. The first was derived from AMBOSS, a commonly used question bank for medical students, which also provides statistics on question difficulty and the performance on an exam relative to the userbase. The second, was the National Board of Medical Examiners (NBME) Free 120-question exams. After prompting ChatGPT with each question, ChatGPT’s selected answer was recorded, and the text output evaluated across three qualitative metrics: logical justification of the answer selected, presence of information internal to the question, and presence of information external to the question. Results: On the four datasets, AMBOSS-Step1, AMBOSS-Step2, NBME-Free-Step1, and NBMEFree-Step2, ChatGPT achieved accuracies of 44%, 42%, 64.4%, and 57.8%. The model demonstrated a significant decrease in performance as question difficulty increased (P=.012) within the AMBOSSStep1 dataset. We found logical justification for ChatGPT’s answer selection was present in 100% of outputs. Internal information to the question was present in > 90% of all questions. The presence of information external to the question was respectively 54.5% and 27% lower for incorrect relative to correct answers on the NBME-Free-Step1 and NBME-Free-Step2 datasets (P<=.001). Conclusion: ChatGPT marks a significant improvement in natural language processing models on the tasks of medical question answering. By performing at greater than 60% threshold on the NBME-FreeStep-1 dataset we show that the model is comparable to a third year medical student. Additionally, due to the dialogic nature of the response to questions, we demonstrate ChatGPT’s ability to provide reasoning and informational context across the majority of answers. These facts taken together make a compelling case for the potential applications of ChatGPT as a medical education tool.

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Research works printed but not linked: 9

  1. 2020, Question-driven summarization of answers to consumer health questions Scientific Data, 7, 1
  2. 2021, Q-Pain: A Question Answering Dataset to Measure Social Bias in Pain Management arXiv preprint
  3. 2022, Thinking about GPT-3 In-Context Learning for Biomedical IE?, Think Again arXiv preprint
  4. Google Scholar https://scholar.google.com/ 2022.
  5. PubMed https://pubmed.ncbi.nlm.nih.gov/ 2022.
  6. 2019, PubMedQA: A dataset for biomedical research question answering arXiv preprint
  7. 2021, What Disease Does This Patient Have? A Large-Scale Open Domain Question Answering Dataset from Medical Exams Applied Sciences, 11, 6421
  8. 1999, Effects of Small-Group Learning on Undergraduates in Science, Mathematics, Engineering, and Technology, A Meta-Analysis Review of Educational Research, 69, 21
  9. 2007, PBL in the undergraduate MD program at McMaster University: three iterations in three decades Academic Medicine, 82, 370

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Metadata

Authors
Gilson, A., Safranek, C., Huang, T., Socrates, V., Chi, L., Taylor, R. A., & Chartash, D.
Affiliations
  • Yale University (US)
  • University College Dublin (IE)
Corresponding author
Chartash, David
ORCID
Venue
medRxiv
Publisher
openRxiv
Published
2022-12-26
DOI
10.1101/2022.12.23.22283901
OpenAlex
W4313232683
Cited by
172
References
3
Citations by year
2026: 9 · 2025: 29 · 2024: 52 · 2023: 82
Type
posted content
Language
en
Open access
Licence
cc-by-nc-nd
Locations
medRxiv (acceptedVersion, cc-by-nc-nd)
Funders
  • Yale University
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (T35DK104689)
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Social Sciences › Education › Innovations in Medical Education
  • Social Sciences › Education › Artificial Intelligence in Education
Keywords
ChatGPT, large language models, USMLE Step 1, USMLE Step 2, medical licensing examinations, multiple-choice question answering, medical education, knowledge assessment, question difficulty, AMBOSS, medical students

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