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PreprintCited by 5Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

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Mechanisms of life cycle simplification in African trypanosomes

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Oldrieve, Guy R, Venter, Frank, Cayla, Mathieu, Verney, Mylene, Hébert, Laurent, Geerts, Manon, Reet, Nick Van, Matthews, Keith R·2024·Nature Communications
DOI 10.1101/2024.07.12.603250PMC PMC11612274

Preprint — published as 10.1038/s41467-024-54555-w · Paper page

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Abstract

African trypanosomes are important parasites in sub-Saharan Africa that undergo a quorum-sensing dependent development to morphologically stumpy forms in mammalian hosts to favour disease transmission by tsetse flies 1 . However, some trypanosome lineages have simplified their lifecycle by escaping dependence on tsetse allowing an expanded geographical range, with direct transmission between hosts achieved via biting flies and vampire bats ( Trypanosoma brucei evansi , causing the disease ‘surra’) or through sexual transmission ( Trypanosoma brucei equiperdum , causing ‘dourine’). Concomitantly, stumpy formation is reduced or lost, and the isolates are described as monomorphic, with infections spread widely in Africa, Asia, South America and parts of Europe. Here, using genomic analysis of distinct field isolates, we identified and functionally confirmed molecular changes that accompany the loss of the stumpy transmission stage in monomorphic clades. Further, using laboratory selection for resistance to the parasite’s quorum-sensing signal, we identified reversible steps in the initial development of monomorphism. This study identifies a trajectory of events that simplify the life cycle in emergent and established monomorphic trypanosomes, with impact on disease spread, vector control strategies, geographical range and virulence.

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Metadata

Authors
Oldrieve, G. R., Venter, F., Cayla, M., Verney, M., Hébert, L., Geerts, M., Reet, N. V., & Matthews, K. R.
Affiliations
  • University of Edinburgh (GB)
  • University of York (GB)
  • Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
  • Instituut voor Tropische Geneeskunde (BE)
Corresponding author
  • Oldrieve, Guy R
  • Matthews, Keith R
ORCID
Venue
Nature Communications
Publisher
openRxiv
Published
2024-07-12
Volume
15
Issue
1
Pages
10485-10485
ISSN
2041-1723 (ISSN-L)
DOI
10.1101/2024.07.12.603250
PMC
PMC11612274
OpenAlex
W4404905045
Cited by
5
References
1
Citations by year
2026: 4 · 2025: 1
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nature Communications (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (submittedVersion, cc-by)
  • Lirias (submittedVersion, cc-by)
  • HAL (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
  • Bill and Melinda Gates Foundation (OPP1174221)
  • Wellcome Trust (221717, 220058/Z/19/Z, /Z/15/Z, 221717/Z/20/Z, 108905/Z/15/Z)
  • Vlaamse regering
  • Medical Research Council (MR/W026996/1)
  • European and Developing Countries Clinical Trials Partnership
Topics
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
African trypanosomes, Trypanosoma brucei, quorum sensing, surra, dourine, tsetse flies, trypanosome motility, parasite virulence, geographic range expansion, vector control
MeSH terms
Animals, Chiroptera, Humans, Life Cycle Stages, Mutation, Trypanosoma brucei brucei, Trypanosomiasis, African, Tsetse Flies, Protozoan Proteins

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